Metamizol

Metamizol is indicated in Pain and Fever.

It inhibits the synthesis of prostaglandins D and E resulting in analgesic, antiinflammatory and antipyretic effects. It also has the potential for causing agranulocytosis.

Adults and children over 18 years: The usual dose is 1.25 gm (2.5 ml) or 2.5 gm (5 ml) once daily. The maximum daily dose is 4 g.

There are no known drug interactions and none well documented.

• Hypersensitivity to any of the ingredients
• Renal failure, pyelonephritis, glomerulonephritis and other renal diseases;
• Inhibition of hematopoiesis functions (neutropenia cytostatic or infectious, agranulocytosis);
• Liver failure;
• Anemias, including hereditary hemolytic anemia;
• Leukopenia;
• Propensity to bronchospasm;
• Optic neuritis;
• Myasthenia gravis, accompanied by severe muscle weakness and fatigue;

Allergic reactions that may occur are usually skin reactions: rash, redness, itching, swelling, gradually swelling of the face and tongue, and a lot more dangerous anaphylactic shock which has the following symptoms: itching, cold sweat, dizziness, lethargy, nausea, redness or paleness of skin and shortness of breath.

Metamizole can cause damage to the bone marrow (granulocytopenia, agranulocytosis, hemolytic anemia, aplastic anemia). Cases of agranulocytosis are rare, but they are still very serious. Symptoms of agranulocytosis include: high fever, chills, sore throat, difficulty swallowing, inflammation of the mouth, nose, throat.

Metamizole can cause digestive disorders such as nausea, vomiting, dry mouth, irritation of the digestive system. You can contact drowsiness, fatigue, weakness, headache, and hypotension, and wheezing.

Category- Not Classified. FDA has not yet classified the drug into a specified pregnancy category.

• Allergic reactions to aspirin and nonsteroidal anti-inflammatory drugs
• Asthma or chronic inflammation of the airways
• Anaemia
• The weakness of the kidney or liver An ulcer in the stomach or duodenum
• Heart disease and systolic blood pressure less than 100 mmHg and unstable circulation disorder (initial shock or heart attack)

Non-Opioid Analgesics