Dorzolamide + Timolol

This Eye Drops is indicated for the treatment of elevated intraocular pressure in patients with open angle glaucoma or ocular hypertension who are insufficiently responsive to topical beta blockers.

Dorzolamide, a carbonic anhydrase inhibitor, has actions similar to acetazolamide. By inhibiting carbonic anhydrase in the ciliary processes of the eye, dorzolamide decreases aqueous humor secretion. Used together, there is additional intraocular pressure reduction compared to using either component alone, but the reduction is not as much as concomitant admin of dorzolamide tid and timolol bid.

Timolol maleate, a nonselective β-adrenergic blocker, reduces aqueous humor formation.

Instill one drop in the conjunctival sac of the affected eye(s) twice daily.

Additive hypotension and bradycardia with oral calcium channel blockers, catecholamine-depleting drugs or β-blockers, antiarrhythmics (e.g. amiodarone), digitalis glycosides, parasympathomimetics, narcotics and MAOIs. Additive systemic side effects with oral carbonic anhydrase or β-blockers; avoid concurrent use. Additive systemic β-blockade with CYP2D6 inhibitors (e.g. quinidine, SSRIs) and timolol.

Contraindicated in patients who are hypersensitive to any of the components of this preparation.

Mild burning, ocular hyperemia, blurred vision may occur.

Use in pregnancy: There are no adequate and well-controlled studies in pregnant women. This Eye Drops should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. 

Use in lactation: Caution should be exercised when This Eye Drops is administered to a nursing mother.

For ophthalmic use only. Patients should remove their contact lenses prior to instilling this preparation and should not insert their lenses until 15 minutes after instillation of the preparation.

Drugs for miotics and glaucoma

Use in children: Safety and effectiveness in children below the age of 2 years have not been established. 

Use in elderly patients: No overall differences in safety and effectiveness have been observed between elderly and other adult patients.

Store between 15-30°C. Protect from light.