Sodium Fusidate (Oral)
Indications
Treatment of infections caused by susceptible organisms especially Staph eg, osteomyelitis, septicaemia, endocarditis, superinfected cystic fibrosis, pneumonia, skin & soft tissue infections, surgical & traumatic wound infections.
Pharmacology
Fusidic acid inhibits bacterial protein synthesis by interfering with amino acid transfer from aminoacyl-tRNA to protein on the ribosomes.
Dosage And Administration
Adult: 250-500 mg every 8 hourly
Skin & soft tissue infection: 250 mg twice daily.
Interaction
Drugs metabolized by CYP450 isoenzymes.
Contraindications
Hypersensitivity
Side Effects
GI disturbances eg, dyspepsia, nausea, vomiting, epigastric pain, anorexia; jaundice & change of liver function.
Pregnancy And Lactation
No data found
Precautions And Warnings
Hepatic impairment, biliary obstruction or disease. Monitor hepatic function periodically in patients on high or prolonged oral doses. Avoid during 3rd trimester of pregnancy. Lactation. Premature, jaundiced, acidotic or seriously ill neonates.
Therapeutic Class
Other antibiotic.
