Neomycin Sulphate + Polymyxin B Sulphate + Pramoxine
Indications
This is a first aid cream. It prevents infections and provides temporary relief of pain or discomfort in minor cuts, scrapes and burns.
Pharmacology
This cream is a combination of Neomycin, Polymyxin B and Pramoxine HCl.
Neomycin is a bactericidal for many gram positive and gram-negative organisms. It is an aminoglycoside antibiotic which inhibits protein synthesis by binding with ribosomal RNA and causing misreading of the bacterial genetic code.
Polymyxin B is bactericidal for a variety of gram-negative organisms. It increases the permeability of the bacterial cell membrane by interacting with the phospholipids components of the membrane.
Pramoxine is an external analgesic that provides temporary relief of pain or discomfort.
Dosage And Administration
Clean the affected area. Apply a small amount of product (an amount equal to the surface area of the tip of a finger). May be covered with a sterile bandage.
Contraindications
Neomycin, Polymyxin B and Pramoxine HCl cream should not be administered to individuals who are hypersensitive to Neomycin, Polymyxin B, Pramoxine or any other components of this product.
Side Effects
Topical antibiotics, particularly Neomycin sulphate, may cause cutaneous sensitization. The manifestations of sensitization to topical antibiotics are usually itching and reddening. When used in small doses, no common side effects have been reported with this product.
Pregnancy And Lactation
Use Neomycin, Polymyxin B and Pramoxine HCl during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not known whether this drug is excreted in breast milk. Exercise caution when applying Nepranol to a nursing mother.
Precautions And Warnings
Do not use this medication in the eyes or apply to large areas of the body. Do not use longer than one week unless directed by the physician.
Therapeutic Class
Anti-infective & Anesthetic combined preparations.
Use in special populations
Safety and effectiveness in children below 2 years of age have not been established.
Storage Conditions
Store in a dry and cool place protected from light and moisture.