Indications
Alverine Citrate is indicated in-
- Irritable Bowel Syndrome
- Bowel movement disturbances caused by small sacs or pouches in the wall of the gut (diverticular disease)
- Abdominal pain associated with menstrual periods (Primary dysmenorrhea)
- Relief of other conditions associated with spasm of involuntary muscle
Pharmacology
Alverine Citrate is a smooth muscle relaxant. Smooth muscle is a type of muscle that is not under voluntary control; it is the muscle present in places such as the gut and uterus. Alverine Citrate acts directly on the muscle in the gut, causing it to relax. This prevents the muscle spasm which occur in the gut in conditions such as irritable bowel syndrome and diverticular disease. Alverine Citrate also relaxes the smooth muscle in the uterus. It is therefore also used to treat painful menstruation, which is caused by muscle spasm in the uterus (dysmenorrhea).
Dosage And Administration
Adult: Orally: 60-120 mg 1-3 times daily.
Interaction
There are no drug interactions reported with this medicine.
Contraindications
Paralytic ileus or known hypersensitivity to any of the ingredients.
Side Effects
Possible side effects may include nausea, headache, dizziness, itching, rash and allergic reactions.
Pregnancy And Lactation
Although no teratogenic effects have been reported, use during pregnancy or lactation is not recommended as evidence of safety in preclinical studies are limited.
Precautions And Warnings
Avoid Alverine Citrate in patients with intestinal obstruction or paralytic ileus.
Overdose Effects
Can produce hypotension and atropine like-toxic effects. Management for overdose is as like as atropine poisoning with continuation of supportive therapy for hypotension.
Therapeutic Class
Anticholinergics
Use in special populations
Children under 12 years: Not recommended
Storage Conditions
Store in a cool and dry place, away from light. Keep all medicines out of the reach of children. Store below 25°C temperature.