Indications
Bromhexine is indicated in the treatment of respiratory tract disorders associated with productive cough. This include-
- Tracheobronchitis
- Bronchitis with emphysema
- Bronchiectasis
- Bronchitis with bronchospasm
- Chronic inflammatory pulmonary conditions and
- Pneumoconiosis.
Pharmacology
Bromhexine Hydrochloride is an oral mucolytic agent. It disrupts the structure of acid mucopolysaccharide fibres in mucoid sputum and produces less viscous mucus, which makes easier the expectoration. It is rapidly & completely absorbed from the gastrointestinal tract. It is widely distributed into the body tissues.
Dosage And Administration
The recommended doses for adults and children are stated below:
- Adult & Children over 12 years: 10 ml (2 teaspoons) 3 times daily
- Children 6-12 years: 5 ml (1 teaspoon) 3 times daily
- Children 2-6 years: 2.5 ml (1/2 teaspoon) 3 times daily
- Bromhexine Hydrochloride is not recommended for children under 2 years of age without advice.
Interaction
There are no known significant interactions with other drugs.
Contraindications
It is contraindicated in known hypersensitivity to Bromhexine Hydrochloride or any of the ingredients of this product.
Side Effects
Gastrointestinal side effects may occur occasionally. A transient rise in serum aminotransferase values has been reported. Other reported side effects include-headache, vertigo (dizziness) and allergic reactions
Pregnancy And Lactation
Use in Pregnancy: Special care is recommended during pregnancy. The benefits of bromhexine must be assessed against possible effects on children.
Use in Lactation: Bromhexine is expected to enter breast milk. Therefore it is not recommended that bromhexine be taken by lactating mothers.
Precautions And Warnings
Since mucolytics may disrupt the gastric mucosa bromhexine should be used with care in patients with a history of peptic ulcer disease. Care is also advisable in asthmatic patients. Clearance of bromhexine and its metabolites may be reduced in patients with severe hepatic or renal impairment.
Therapeutic Class
Cough expectorants & mucolytics
Storage Conditions
Keep in a dry place away from light and heat. Keep out of reach of children.