Combipen Injection

It is indicated for the treatment or prevention of any infection caused by Penicillin sensitive bacteria where a long acting Penicillin is required. It is indicated in-

• Gonorrhoea caused by Penicillin sensitive microorganisns
• Prevention of endocarditis during dental procedures
• Gas-gangrene following amputation

Benzylpenicillin has a bactericidal action against gram-positive bacteria, gram-­negative cocci, some other gram-negative bacteria, spirochetes and actinomycetes. It inhibits final cross-linking stage of peptidoglycan production through binding and inactivation of transpeptidases on the inner surface of the bacterial cell membrane thus inhibiting bacterial cell wall synthesis. It is inhibited by penicillinase and other lactamases.

Interferes with cell wall mucopeptide synthesis during active multiplication, resulting in bactericidal activity against susceptible microorganisms.

Add 3 ml of water for injection and shake vigorously.

Adults: 4,00,000 units once daily or twice daily.
Children: Over 25 kg as for adults; under 25 kg reduce proportionally. In severe cases dose may be doubled.

Intramuscular injection is the only route of administration of Procaine Penicillin.

Administration

This should be injected IM into the buttocks, thigh, deltoid or triceps muscle. In case continuous injection is necessitated, the injection site should be changed every time.

Potentially hazardous interactions: invitro Penicillin inactivates Amino- glycosides, so that they should not be mixed in infusion fluids.

Hypersensitivity to penicillin.

Allergic reactions may occur but usually resolve on cessation of therapy.

Pregnancy Category B. Either animal-reproduction studies have not demonstrated a fetal risk but there are no controlled studies in pregnant women or animal-reproduction studies have shown an adverse effect that was not confirmed in controlled studies in women in the 1st trimester.

Hypersensitivity to cephalosporins. Renal impairment. CHF. Infant. Elderly.

Benzylpenicillin & Phenoxymethyl penicillin.

Store at room temperature.