<p>The recommended starting dose is one to two drops of Levobunolo ophthalmic solution 0.5% in the affected eye(s) once a day. Typical dosing with Levobunolol 0.25% is one to two drops twice daily. In patients with more severe or uncontrolled&nbsp;glaucoma, Levobunolo 0.5% can be administered&nbsp;b.i.d.&nbsp;As with any new medication, careful monitoring of patients is advised. Dosages above one drop of Levobunolol 0.5% b.i.d. are not generally more effective. If the patient&#39;s&nbsp;IOP&nbsp;is not at a satisfactory level on this regimen, concomitant therapy with dipivefrin and/or&nbsp;epinephrine, and/or pilocarpine and other miotics, and/or systemically administered carbonic anhydrase inhibitors, such as acetazolamide, can be instituted. Patients should not typically use two or more topical ophthalmic beta-adrenergic blocking agents simultaneously.</p>