<p><strong>Initial therapy</strong>: Irbesartan 150 mg &amp; Hydrochlorothiazide 12.5 mg orally once a day; may increase after 1 to 2 weeks.<br />
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<strong>Add-on/Replacement therapy</strong>: Irbesartan 150 to 300 mg &amp; Hydrochlorothiazide 12.5 to 25 mg orally once a day<br />
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<strong>Maximum dose</strong>: Irbesartan 300 mg &amp; Hydrochlorothiazide 25 mg orally once a day</p>