<ul>
	<li>Increases the risk of bleeding. Avoid intramuscular injections. Monitor for bleeding. If serious bleeding occurs, discontinue Alteplase.</li>
	<li>Monitor patients during and for several hours after infusion for orolingual angioedema. If angioedema develops, discontinue Alteplase.</li>
	<li>Cholesterol embolism has been reported rarely in patients treated with thrombolytic agents.</li>
	<li>Consider the risk of reembolization from the lysis of underlying deep venous thrombi in patients with pulmonary embolism.</li>
</ul>