<p><strong>Geriatric patients</strong>: Dose reduction to half normal adult dose is recommended in geriatric patients (over 70 years).<br />
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<strong>Liver impairment</strong>: Dosage reduction and/or increased dosage intervals are recommended.<br />
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<strong>Renal impairment</strong>: Due to the possibility of accumulation of norpethidine in patients with renal failure, caution should be exercised when pethidine is administered to these patients, especially over prolonged periods of time. Therefore, a decrease in the dose or increase in the dosing interval is recommended.</p>