<p><strong>Bradycardia and Sinus Arrest</strong>: Consider decreasing or stopping dexmedetomidine HCl infusion; decreasing or stopping other medications that depress sinus node function; administering anticholinergic agents (e.g., glycopyrrolate, atropine); and/or administering pressor agents.&nbsp;&nbsp;<br />
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<strong>Hypotension</strong>: Consider decreasing or stopping dexmedetomidine HCl infusion; increasing rate of intravenous fluid administration; elevating lower extremities, and/or administering pressor agents.<br />
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<strong>Transient Hypertension</strong>: Observed primarily during administration of loading dose. Consider reducing loading infusion rate.<br />
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<strong>Arousability</strong>: Patients can become aroused/alert with stimulation; this alone should not be considered as lack of efficacy.<br />
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Prolonged exposure to dexmedetomidine beyond 24 hours may be associated with tolerance and tachyphylaxis and a dose-related increase in adverse events.</p>