<p>Adverse events occurring in &ge;2% of patients at recommended doses - Abdominal pain 4.1%, diarrhoea 5.6%, dyspepsia 8.8%, flatulence 2.2%, nausea 3.5%, back pain 2.8%, peripheral oedema 2.1%, accidental injury 2.9%, dizziness 2.0%, headache 15.8%, insomnia 2.3%, pharyngitis 2.3%, rhinitis 2.0%, sinusitis 5.0%, upper respiratory tract infections 8.1%, rash 2.2%. The following adverse events occurred in 0.1-1.9% of patients-</p>

<ul>
	<li><strong>General</strong>: Allergy aggravated, allergic reaction, asthenia, chest pain, oedema generalised, face oedema, fatigue, fever, hot flushes, influenza like symptoms, pain, peripheral pain.</li>
	<li><strong>Gastrointestinal</strong>: Constipation, diverticulitis, dysphagia, oesophagitis, gastritis, gastroenteritis, gastro-oesophageal reflux disease, haemorrhoids, hiatal hernia, melaena, dry mouth, stomatitis, tenesmus, tooth disorder, vomiting.</li>
	<li><strong>Cardiovascular</strong>: Aggravated hypertension, angina pectoris, coronary artery disease, myocardial infarction.</li>
	<li><strong>Nervous system</strong>: Leg cramps, hypertonia, hypoesthesia, migraine, neuralgia, neuropathy, paresthesia, vertigo. Female reproductive system : Breast fibroadenosis, breast neoplasm, breast pain, dysmenorrhoea, menstrual disorder, menorrhagia, vaginitis.</li>
	<li><strong>Male reproductive system</strong>: Prostatic disorder.</li>
	<li><strong>Resistance mechanism disorders</strong>: Herpes simplex, herpes zoster, bacterial infection, fungal infection, infection of soft tissue, viral infection, moniliasis, moniliasis genital, otitis media.</li>
	<li><strong>Hearing and vestibular</strong>: Deafness, ear abnormality, earache, tinnitus.</li>
	<li><strong>Heart rate and rhythm</strong>: Palpitation, tachycardia.</li>
	<li><strong>Respiratory</strong>: Bronchitis, bronchospasm, bronchospasm aggravated, coughing, dyspnoea, laryngitis, pneumonia.</li>
	<li><strong>Liver and biliary system</strong>: Peptic function abnormal, increased AST and ALT.</li>
	<li><strong>Musculoskeletal</strong>: Arthralgia, arthrosis, accidental fracture, myalgia, neck stiffness, synovitis, tendinitis.</li>
	<li><strong>Urinary system</strong>: Albuminuria, cystitis, dysuria, haematuria, micturition frequency, renal calculus, urinary incontinence, urinary tract infection.</li>
	<li><strong>Metabolic and nutritiona</strong>l: Blood urea nitrogen (BUN), CPK, creatinine, alkaline phosphatase, are increased. Hypercholesterolaemia, hyperglycaemia, hypokalaemia. Bodyweight is also increased.</li>
	<li><strong>Psychiatric</strong>: Anorexia, anxiety, increased appetite, depression, nervousness, somnolence.</li>
	<li><strong>Haemic</strong>: Anaemia, ecchymosis, epistaxis, thrombocythaemia.</li>
	<li><strong>Skin and appendages</strong>: Alopecia, dermatitis, photosensitivity reaction, pruritus, rash erythematous, rash maculopapular, skin disorder, dry skin, increased sweating, urticaria.</li>
	<li><strong>Application site disorders</strong>: Cellulitis, contact dermatitis, skin nodule.</li>
	<li><strong>Special sense</strong>s: Taste perversion.</li>
	<li><strong>Vision</strong>: Blurred vision, cataract, conjunctivitis, eye pain, glaucoma.</li>
</ul>