<p><strong>Elderly</strong>: As with other antipsychotics, Quetiapine should be used with caution in the elderly, especially during the initial dosing period. The rate of dose titration may need to be slower, and the daily therapeutic dose lower, than that used in younger patients, depending on the clinical response and tolerability of the individual patient. The mean plasma clearance of Quetiapine was reduced by 30% to 50% in elderly subjects when compared with younger patients.<br />
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<strong>Children and Adolescents</strong>: Quetiapine is not indicated for use in children and adolescents below 18 years of age.</p>