<p>One 400 mg tablet taken once daily with or without food. Should be used in combination with Ribavirin or in combination with Pegylated Interferon and Ribavirin for the treatment of CHC.<br />
<br />
Recommended combination therapy: (HCV Mono-infected and HCV/HIV-1 Co-infected)-</p>

<ul>
	<li><strong>Genotype 1 or 4</strong>: Sofosbuvir + Peginterferon alfa + Ribavirin for 12 weeks</li>
	<li><strong>Genotype 2</strong>: Sofosbuvir + Ribavirin for 12 weeks</li>
	<li><strong>Genotype 3</strong>: Sofosbuvir + Ribavirin for 24 weeks</li>
</ul>

<p>Sofosbuvir in combination with Ribavirin for 24 weeks can be considered for CHC patients with genotype 1 infection who are Interferon ineligible<br />
<br />
Should be used in combination with Ribavirin for treatment of CHC in patients with hepatocellular carcinoma awaiting liver transplantation for up to 48 weeks or until liver transplantation whichever occurs first<br />
<br />
A dose recommendation cannot be made for patients with severe renal impairment or end stage renal disease</p>