<p>In the following cases, Perindopril should be used with caution:</p>

<ul>
	<li>Renovascular hypertension</li>
	<li>Surgery/Anesthesia</li>
	<li>Renal failure: The dose should be cautiously adjusted in accordance with the creatinine clearance</li>
	<li>Symptomatic hypotension is rarely seen, but is more likely in volume-depleted patients, those receiving diuretics, or with the first two doses</li>
	<li>In diuretic-treated patients: stop the diuretic 3 days before starting Perindopril. A&nbsp;diuretic may later be given in combination if necessary; potassium-sparing diuretics are not recommended</li>
	<li>Combination with neuroleptics or imipramine-type drugs may increase the hypotensive effect. Serum lithium concentrations may rise during lithium therapy</li>
</ul>