<p><strong>Patients with renal impairment</strong>: The use of Zoledronic Acid is not recommended in patients with severe renal impairment (Creatinine clearance &lt;30 ml/min). No dose adjustment is necessary in patients with creatinine clearance &gt;60 ml/min. Based on creatinine clearance the following dose should be used in patient with impaired renal function:</p>

<ul>
	<li>CrCl &gt; 60 ml/min: 4 mg (5 ml)</li>
	<li>CrCl 50-60 ml/min: 3.5 mg (4.4 ml)</li>
	<li>CrCl 40-49 ml/min: 3.3 mg (4.1 ml)</li>
	<li>CrCl 30-39 ml/min: 3 mg (3.8 ml)</li>
</ul>