<p>Known hypersensitivity to atropine or its derivatives, or to any of the ingredients of Ipratropium bromide nasal spray (sodium chloride, benzalkonium chloride, disodium edetate dihydrate). Immediate hypersensitivity reactions may occur after administration of Ipratropium bromide, as demonstrated by rare cases of urticaria, angioedema, rash, bronchospasm, and oropharyngeal edema.</p>