<p><strong>Hypertension</strong>-</p>

<ul>
	<li>The usual starting dose of 50/12.5 is one tablet once daily.</li>
	<li>For patients who do not respond adequately to one tablet the dosage may be increased to 100/25 once daily.</li>
	<li>A patient whose blood pressure is not adequately controlled with Losartan 100 mg monotherapy may be switched to this combination 100/12.5 once daily.</li>
	<li>In hypertensive patients with left ventricular hypertrophy initial dose is 50/12.5, if additional blood pressure reduction is needed, 100/12.5 may be given, followed by 100/25 if required. The maximum dose is 100/25 once daily.</li>
	<li>In general, the antihypertensive effect is attained within three weeks after initiation of therapy.</li>
	<li>No initial dosage adjustment of 50/12.5 is necessary for elderly patients. But maximum dose of 100/25 once daily dose should not be used as initial therapy in elderly patients.</li>
</ul>

<p><strong>Severe Hypertension</strong>:</p>

<ul>
	<li>The starting dose for initial treatment of severe hypertension is one tablet of 50/12.5 once daily.</li>
	<li>For patients who do not respond adequately to this dose after 2 to 4 weeks of therapy, the dosage may be increased to 100/25 once daily. The maximum dose is one tablet of 100/25 once daily.</li>
</ul>

<p>&nbsp;</p>

<p><strong>Administration</strong></p>

<p>This preparation may be administered with other antihypertensive agents. This may be administered with or without food.</p>