<p>The recommended starting dose is 200 mcg twice daily. Tolerability may be improved when taken with food. Increase the dose by 200 mcg twice daily at weekly intervals to the highest tolerated dose up to 1600 mcg twice daily. The maintenance dose is determined by tolerability.<br />
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<strong>Pediatric use</strong>: Safety and effectiveness in pediatric patients have not been established.<br />
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<strong>Geriatric use</strong>: No overall differences have been observed.<br />
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<strong>Hepatic impairment</strong>: For Moderate hepatic impairment patients starting dose is 200 mcg once daily, increase the dose by 200 mcg once daily at weekly intervals to the highest tolerated dose up to 1600 mcg. Avoid use of Selexipag in patients with severe hepatic impairment (Child-Pugh class C).</p>