<p>Although animal studies have not shown any harmful&nbsp;effect of Nicorandil to the foetus, has not been studied in human pregnancy. Use in pregnant&nbsp;women requires that the anticipated benefit be weighed against possible hazard. It is not known&nbsp;whether the drug is excreted in human milk. Caution should be exercised when Nicorandil is&nbsp;administered to a nursing mother. Drug interactions: Although no pharmacological and/or&nbsp;pharmacokinetic interaction has been obsen/ed in animal and human studies with Nicorandil&nbsp;associated with beta-blockers, calcium antagonists, digoxin, a combination of digoxin/furosemide,&nbsp;rifampicin, and cimetidine, it is not excluded that the drug may nevertheless potentiate the effect&nbsp;of other vasodilators, tricyclic antidepressants and antihypertensive drugs administered&nbsp;concurrently, especially in combination with alcohol.</p>