<p><strong>Children with hypertension from 6 years to 17 years of age</strong>: 2.5 mg once daily as a starting dose, up-titrated to 5 mg once daily if blood pressure goal is not achieved after 4 weeks. Doses in excess of 5 mg daily have not been studied in pediatric patients.<br />
<br />
<strong>Children under 6 years old</strong>: &nbsp;The effect of amlodipine on blood pressure in patients less than 6 years of age is not known.<br />
<br />
<strong>Elderly</strong>: Amlodipine used at similar doses in elderly or younger patients is equally well tolerated. Normal dosage regimens are recommended in the elderly, but increase of the dosage should take place with care.<br />
<br />
<strong>Renal impairment</strong>: Changes in amlodipine plasma concentrations are not correlated with degree of renal impairment, therefore the normal dosage is recommended. Amlodipine is not dialysable.<br />
<br />
<strong>Hepatic impairment</strong>: Dosage recommendations have not been established in patients with mild to moderate hepatic impairment; therefore dose selection should be cautions and should start at the lower end of the dosing range. The pharmacokinetics of Amlodipine have not been studied in severe hepatic impairment. Amlodipine should be initiated at the lowest dose (2.5 mg once daily) and titrated slowly in patients with severe hepatic impairment.</p>