<p><strong>Nausea:</strong>&nbsp;Patients taking Lubiprostone may experience nausea. Concomitant administration of food with Lubiprostone may reduce symptoms of nausea.<br />
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<strong>Diarrhea:</strong>&nbsp;Lubistone should not be prescribed to patients that have severe diarrhea.<br />
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<strong>Bowel Obstruction:</strong>&nbsp;In patients with symptoms suggestive of mechanical gastrointestinal obstruction, perform a thorough evaluation to confirm the absence of an obstruction prior to initiating therapy with Lubiprostone.</p>