<p>Mirtazapine has clinically significant drug-drug interactions with Monoamine Oxidase Inhibitors (MAOI) &amp; other serotonergic drugs such as tryptophan, triptans, linezolid, serotonin reuptake inhibitors, venlafaxine, lithium, tramadol, or St. John&#39;s wort. Mirtazapine may interrupt the metabolism or activity of Carbamazepine, Phenytoin or Cimetidine. Patient should avoid Alcohol &amp; Diazepam while taking Mirtazapine.</p>