<p><strong>In case of prevention and treatment of NSAID induced gastric and duodenal ulcer</strong>: Misoprostol is contraindicated in women who are pregnant, and should not be used in women of child bearing potential unless the patient requires NSAID therapy. Women of child bearing potential should be told that they must not be pregnant when Misoprostol therapy is initiated and they must use an effective contraception method while taking misoprostol.<br />
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<strong>In case of induction of labor</strong>: The pregnancy should have completed 38 weeks gestation by reliable dating, or lung maturity as evidenced by a L/S &gt;2.0 or a positive phosphotidyl glycerol test, or completed 36 weeks gestation with a maternal or fetal medical indication for induction of labor. Induction of labor is contraindicated in acute fetal distress, abruptio placenta, placenta previa or unexplained vaginal bleeding. The fetus should be in vertex presentation.</p>