<p>Nausea, vomiting, abdominal pain, pruritus, headache, and increasing lethargy&nbsp;will probably occur within a short time after ingestion; unconsciousness may occur when there is severe hepatic disease. Transient increases in liver enzymes and/or bilirubin may occur. Brownish-red or orange discoloration of the skin, urine, sweat, saliva, tears, and feces will occur, and its intensity is proportional to the amount ingested.<br />
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Liver enlargement, possibly with tenderness, can develop within a few hours after severe overdosage; bilirubin levels may increase and&nbsp;jaundice&nbsp;may develop rapidly. Hepatic involvement may be more marked in patients with prior impairment of hepatic function. Other physical findings remain essentially normal. A direct effect upon the hematopoietic&nbsp;system,&nbsp;electrolyte&nbsp;levels, or&nbsp;acid-base balance&nbsp;is unlikely.<br />
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Facial or periorbital edema has also been reported in pediatric patients. Hypotension, sinus tachycardia, ventricular arrhythmias, seizures and cardiac arrest were reported in some fatal cases.</p>