<p><strong>Children</strong>: Safety and effectiveness in pediatric patients have not been established.<br />
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<strong>Elderly</strong>: No dose adjustment is required for elderly patients.<br />
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<strong>Hepatic impaired patients</strong>: Should be administered cautiously to patients with mild to moderate hepatic impairment. Dose reduction may be needed.<br />
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<strong>Renally impaired patients</strong>: Should be administered cautiously to patients in severe renal impairment including those receiving dialysis therapy</p>