<p><strong>Adults and children</strong>: 15 mg/kg/day in two equally-divided doses (equivalent to 500 mg bid in adults). Use of the 100 mg is recommended for children for the accurate measurement of the appropriate dose.<br />
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<strong>Neonates and premature children</strong>: An initial loading dose of 10 mg/kg followed by 15 mg/kg/day in two equally divided doses.<br />
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<strong>Elderly</strong>: Amikacin is excreted by the renal route. Renal function should be assessed whenever possible and dosage adjusted as described under impaired renal function.<br />
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<strong>Life-threatening infections and/or those caused by Pseudomonas</strong>: The adult dose may be increased to 500 mg every eight hours but should neither exceed 1.5g/day nor be administered for a period longer than 10 days. A maximum total adult dose of 15g should not be exceeded.<br />
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<strong>Urinary tract infections</strong>&nbsp;(other than pseudomonal infections): 7.5mg/kg/day in two equally divided doses (equivalent to 250 mg b.i.d. in adults).<br />
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<strong>Impaired renal function</strong>: In patients with impaired renal function, the daily dose should be reduced and/or the intervals between doses increased to avoid accumulation of the drug.</p>

<p><strong>Administration</strong></p>

<p><strong>Intramuscular or intravenous administration</strong>: For most infections the intramuscular route is preferred, but in life threatening infections, or in patients in whom intramuscular injection route is not feasible the intravenous route may be used.<br />
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<strong>Intraperitoneal use</strong>: Amikacin may be used as an irrigant after recovery from anesthesia in concentration of 0.25%.</p>