<p><strong>Pediatric Use</strong>: The safety and effectiveness of Esmolol Hydrochloride in pediatric patients have not been established.<br />
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<strong>Geriatric Use</strong>: Clinical studies of Esmolol Hydrochloride did not include sufficient numbers of subjects aged 65 and over to determine whether they responded differently from younger subjects.<br />
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<strong>Hepatic Impairment</strong>: No special precautions are necessary in patients with hepatic impairment because Esmolol Hydrochloride is metabolized by red-blood cell esterases.<br />
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<strong>Renal Impairment</strong>: No dosage adjustment is required for esmolol in patients with renal impairment receiving a maintenance infusion of esmolol 150 mcg/kg for 4 hours.</p>