<ul>
	<li>Known hypersensitivity to tizanidine or to any of the excipients.</li>
	<li>Severely impaired hepatic function.</li>
	<li>Concomitant use of tizanidine with strong inhibitors of CYP1A2 such as fluvoxamine or ciprofloxacin is contraindicated.</li>
</ul>