<p><strong>Pediatric Use</strong>: Safety and effectiveness of&nbsp;combination of Rosiglitazone and Metformin in pdiatric patients have not been established.<br />
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<strong>Geriatric Use</strong>: Because aging is associated with&nbsp;reduced renal function, combination of Rosi litazone and Metformin should be used with caution as age increases. Care should be taken in dose selection and should be based on careful and regular monitoring of renal function. Generally, elderly patients should not be titrated to the maximum dose of combination of Rosiglitazone and Metformin.</p>