<p><strong>Dose in Elderly Patients</strong>: No dosage adjustment is necessary, unless kidney function is impaired.<br />
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<strong>Dose in Renal Impairment</strong>: Although no dosage adjustment is recommended in patients with moderate (creatinine clearance: 30-50 ml/min) and mild (creatinine clearance: 50 80 ml/min) renal impairment, all such patients should be observed carefully for signs and symptoms of bleeding. For patients with severe (creatinine clearance &lt;30 ml/min) renal impairment, following dosage adjustments are recommended: Prophylactic dose ranges: 2000 antiXa IU once daily; Therapeutic dose ranges: 100 anti-Xa lU/kg once daily.<br />
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<strong>Dose in Hepatic Impairment</strong>: Caution should be used in hepatically impaired patients.</p>