<p>Intravenous (Adult)-<br />
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<strong>Non-Hodgkin&#39;s lymphoma, Refractory or relapsed follicular lymphoma</strong>: As a single agent, 375 mg/m2&nbsp;infusion once wkly, for 4 doses at an initial rate of 50 mg/hr. May increase by 50 mg/hr every 30 min. If tolerated, subsequent infusions can be started at 100 mg/hr and increased by 100 mg/hr every 30 min. Max rate: 400 mg/hr. When used with CVP (cyclophosphamide, vincristine and prednisolone) for follicular lymphoma or CHOP (cyclophosphamide, doxorubicin, vincristine and prednisone) for diffuse large B-cell lymphoma, 375 mg/m2&nbsp;given on day 1 of the chemotherapy cycle after corticosteroid regimen, for up to 8 cycles. For patients who were treated with 6-8 cycles of CVP chemotherapy and have not progressed, 375 mg/m2&nbsp;may be given once wkly for 4 doses, may repeat every 6 mth, for up to 16 doses. Maintenance: 375 mg/m2&nbsp;given once every 3 mth (those who have responded to induction chemotherapy), once every 2 mth initiated 2 mth after the last dose of induction chemotherapy (previously untreated) for a max period of 2 yr.<br />
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<strong>Chronic lymphocytic leukaemia</strong>: 375 mg/m2, given on the day prior to chemotherapy in cycle 1, followed by 500 mg/m2&nbsp;on day 1 (every 28 days) of cycles 2-6.<br />
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<strong>Rheumatoid arthritis:</strong>&nbsp;Given as two 1 g IV infusion doses, separated by 2 wk and in combination with methotrexate. Corticosteroids may be given before each infusion to minimise the risk and severity of infusion reactions.</p>