<p><strong>Pediatric Use</strong>: Safety and effectiveness of Ledipasvir and Sofosbuvir have not been established in pediatric patients.<br />
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<strong>Geriatric Use</strong>: No overall differences in safety or effectiveness were observed between these subjects and younger subjects, and other reported clinical experience has not identified differences in responses between the elderly and younger patients. No dosage adjustment of Ledipasvir and Sofosbuvir is warranted in geriatric patients.</p>