<p><strong>Recommended Doses and Schedules</strong>: Do not administer as an intravenous push or bolus. Do not mix Trastuzumab with other drugs.<br />
<br />
<strong>Adjuvant Treatment, Breast Cancer</strong>: Administer according to one of the following doses and schedules for a total of 52 weeks of Trastuzumab therapy:<br />
<br />
<strong>During and following paclitaxel, docetaxel, or docetaxel/carboplatin</strong>:</p>

<ul>
	<li>Initial dose of 4 mg/kg as an intravenous infusion over 90 minutes then at 2 mg/kg as an intravenous infusion over 30 minutes weekly during chemotherapy for the first 12 weeks (paclitaxel or docetaxel) or 18 weeks (docetaxel/carboplatin).</li>
	<li>One week following the last weekly dose of Trastuzumab, administer Trastuzumab at 6 mg/kg as an intravenous infusion over 30&minus;90 minutes every three weeks.</li>
</ul>

<p><strong>As a single agent within three weeks following completion of multi-modality, anthracycline-based chemotherapy regimens</strong>:</p>

<ul>
	<li>Initial dose at 8 mg/kg as an intravenous infusion over 90 minutes</li>
	<li>Subsequent doses at 6 mg/kg as an intravenous infusion over 30&minus;90 minutes every three weeks.</li>
	<li>Extending adjuvant treatment beyond one year is not recommended</li>
</ul>

<p><strong>Metastatic Treatment, Breast Cancer</strong>: Administer Trastuzumab, alone or in combination with paclitaxel, at an initial dose of 4 mg/kg as a 90 minute intravenous infusion followed by subsequent once-weekly doses of 2 mg/kg as 30-minute intravenous infusions until disease progression.<br />
<br />
<strong>Metastatic Gastric Cancer</strong>: Administer Trastuzumab at an initial dose of 8 mg/kg as a 90-minute intravenous infusion followed by subsequent doses of 6 mg/kg as an intravenous infusion over 30&ndash;90 minutes every three weeks until disease progression. Or, as directed by the registered physician.</p>

<p><a href="https://medex.com.bd/news/104/danger-of-taking-medication-without-doctors-advice" target="_blank"><em>* চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন</em></a>&#39;</p>

<p>Administration</p>

<ul>
	<li>Using a sterile syringe, slowly inject the 20 ml of diluent into the vial containing the lyophilized powder of Trastuzumab, which has a cake-like appearance. The stream of diluent should be directed into the cake. The reconstituted vial yields a solution for multiple-dose use, containing 21 mg/ml Trastuzumab.</li>
	<li>Swirl the vial gently to aid reconstitution. DO NOT SHAKE.</li>
	<li>Slight foaming of the product may be present upon reconstitution. Allow the vial to stand undisturbed for approximately 5 minutes.</li>
	<li>Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration, whenever solution and container permit. Inspect visually for particulates and discoloration. The solution should be free of visible particulates, clear to slightly opalescent and colorless to pale yellow.</li>
	<li>Store reconstituted Trastuzumab in the refrigerator at 2&deg;C to 8&deg;C, discard unused Trastuzumab after 28 days. If Trastuzumab is reconstituted with SWFI without preservative, use immediately and discard any unused portion.</li>
</ul>