<p>The dosage should be individualized based on effectiveness and tolerability. Take this combination twice daily with meals. Dose escalation should be gradual to reduce the gastrointestinal side effects due to Metformin Hydrochloride. Maximum recommended daily dose of Metformin Hydrochloride is 2000 mg and Empagliflozin is 25 mg.<br />
<br />
Recommended individualized starting dose:</p>

<ul>
	<li>In patients on Metformin Hydrochloride, switch to this combination containing Empagliflozin 5 mg with a similar total daily dose of Metformin Hydrochloride.</li>
	<li>In patients on Empagliflozin, switch to this combination containing Metformin Hydrochloride 500 mg with a similar total daily dose of Empagliflozin.</li>
	<li>In patients already treated with Empagliflozin and Metformin Hydrochloride separately switch to this combination containing the same total daily doses of each component.</li>
	<li>In patients with volume depletion not previously treated with Empagliflozin, correct this condition before initiating this combination.</li>
</ul>

<p><strong>Renal impaired patient</strong>: Assess renal function before initiating this combination. In patients with an eGFR below 45 mL/min/1.73 m2&nbsp;is contraindicated.<br />
<br />
<strong>Pediatric patients under 18 years of age</strong>: Safety and effectiveness in pediatric patients under 18 years of age have not been established.</p>

<p><a href="https://medex.com.bd/news/104/danger-of-taking-medication-without-doctors-advice" target="_blank"><em>* চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন</em></a>&#39;</p>