<p><strong>Post Operative Nausea and Vomiting</strong>: The recommended oral dosage of Aprepitant is 40 mg within 3 hours prior to induction of anesthesia.<br />
<br />
<strong>Chemotherapy-Induced Nausea and Vomiting</strong>:<br />
<br />
** The following regimen should be used for the prevention of nausea and vomiting associated with highly emetogenic cancer chemotherapy-</p>

<ul>
	<li><strong>Day 1</strong>: Aprepitant 125 mg orally, Dexamethasone 12 mg orally, 5-HT3 antagonist (Ondansetron): 24 mg 30 minutes before the start of chemotherapy.</li>
	<li><strong>Day 2</strong>: Aprepitant 80 mg orally, Dexamethasone 8 mg orally</li>
	<li><strong>Day 3</strong>: Aprepitant 80 mg orally, Dexamethasone 8 mg orally</li>
	<li><strong>Day 4</strong>: Dexamethasone 8 mg orally</li>
</ul>

<p>Aprepitant is administered orally 1 hour prior to chemotherapy treatment on Day 1 and in the morning on Days 2 and 3. Dexamethasone is administered 30 minutes prior to chemotherapy treatment on Day 1 and in the morning on Days 2 through 4. The dose of dexamethasone accounts for drug interactions.<br />
<br />
** The following regimen should be used for the prevention of nausea and vomiting associated with moderately emetogenic cancer chemotherapy:</p>

<ul>
	<li><strong>Day 1</strong>: Aprepitant 125 mg orally, Dexamethasone 12 mg orally, 5-HT3 antagonist (Ondansetron): one 8 mg tablet 30 minutes before chemotherapy followed by an 8 mg dose 8 hours later.</li>
	<li><strong>Day 2</strong>: Aprepitant 80 mg orally, 5-HT3 antagonist (Ondansetron): 8 mg tablet twice a day</li>
	<li><strong>Day 3</strong>: Aprepitant 80 mg orally, 5-HT3 antagonist (Ondansetron): 8 mg tablet twice a day.</li>
</ul>

<p>Aprepitant is administered orally 1 hour prior to chemotherapy treatment on Day 1 and in the morning on Days 2 and 3. Dexamethasone is administered 30 minutes prior to chemotherapy treatment on Day 1. The dose of dexamethasone accounts for drug interactions.</p>

<p>&nbsp;</p>

<p><strong>Administration</strong></p>

<p>Aprepitant may be taken with or without food. No dosage adjustment is necessary for the elderly patients.</p>