<p>The appropriate anti-infective cover should be given in the presence of viral or fungal infection. Prolonged use should be avoided in conditions where absorption of neomycin is possible. Do not apply to the external auditory canal of patients with perforated eardrums. Long-term continuous topical steroid therapy can produce atrophic skin changes. Do not apply to the face for prolonged periods. Prolonged use or treatment of extensive areas can produce adrenal suppression, especially in infants and children.</p>