<p>No case of overdose has been reported in clinical studies with Roflumilast. However, during the Phase I studies of Roflumilast, at an increased rate after a single oral dose of 2500 mcg and a single dose of 5000 mcg,<br />
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<strong>The following symptoms were observed</strong>:&nbsp;headache, gastrointestinal disorders, dizziness, palpitations, lightheadedness, clamminess and arterial hypotension.<br />
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<strong>Missed Dose</strong>: Patients should be advised that if they forget to take a tablet at the usual time, they should take the tablet as soon as they remember or continue on the next day with the next tablet at the usual time. Patients should not take a double dose to make up for a forgotten dose.</p>