<p><strong>Elderly</strong>: No dosage adjustment is necessary since bioavailability, distribution and elimination were&nbsp;similar in elderly (60 years of age or older) compared to younger subjects. This has also been&nbsp;shown in the very elderly, 75 years old and above postmenopausal population.&nbsp;<br />
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<strong>Renal impairment</strong>: No dosage adjustment is required for those patients with mild to moderate&nbsp;renal impairment. The use of Risedronate Sodium is contra-indicated in patients with severe&nbsp;renal impairment (Creatinine clearance lower than 30ml/min).</p>