<p>High dosages, prolonged treatment and/or too frequent administration may cause:</p>

<ul>
	<li>Virilisation which appears in sensitive women as hoarseness, acne hirsutism and increase of libido; in prepubertal boys as an increased frequency of erections and phallic enlargement, and in girls as an increase of pubic hair and clitoral hypertrophy. Hoarseness may be the first symptom of vocal change which may end in a long-lasting, sometimes irreversible deepening of the voice.</li>
	<li>Amenorrhoea.</li>
	<li>Inhibition of spermatogenesis.</li>
	<li>Premature epiphyseal closure.</li>
	<li>Fluid retention.</li>
</ul>