<p><strong>Geriatric use</strong>: The usual doses can be administered to elderly people; however, caution is advised when the dose is increased.<br />
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<strong>Pediatric use</strong>: The safety and efficacy of Bisoprolol fumarate/amlodipine in children and adolescents below the age of 18 years have not been established. No data are available.<br />
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<strong>Patients with Liver disease</strong>: In case of hepatic impairment elimination of amlodipine may be elongated. Exact dosage recommendations concerning amlodipine have not been established, but the drug should therefore be administered with special caution in these patients. In case of severe hepatic impairment, the daily dose of bisoprolol must not exceed 10 mg.<br />
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<strong>Patients with Kidney disease</strong>: No dosage adjustment is required for patients with mild to moderate renal impairment. Amlodipine is not dialyzable. Amlodipine should be administered with particular caution to patients undergoing dialysis. In case of severe renal impairment (creatinine clearance &lt;20 ml/min) the daily dose of bisoprolol must not exceed 10 mg</p>