<p><strong>Lithium and Digoxin:</strong>&nbsp;Diclofenac may increase plasma concentrations of Lithium and Digoxin.<br />
<br />
<strong>Anticoagulants:</strong>&nbsp;There are isolated reports of an increased risk of haemorrhage with the combined use of Diclofenac and anticoagulant therapy, although clinical investigations do not appear to indicate any influence on anticoagulant effect.<br />
<br />
<strong>Antidiabetic agents:&nbsp;</strong>Clinical studies have shown that Diclofenac can be given together with oral antidiabetic agents without influencing their clinical effect.<br />
<br />
<strong>Cyclosporin:&nbsp;</strong>Cases of nephrotoxicity have been reported in patients receiving Cyclosporin and Diclofenac concomitantly.<br />
<br />
<strong>Methotrexate:&nbsp;</strong>Cases of serious toxicity have been reported when Methotrexate and NSAIDs are given within 24 hours of each other.<br />
<br />
<strong>Quinolone antimicrobials:</strong>&nbsp;Convulsions may occur due to an interaction between quinolones and NSAIDs. Therefore, caution should be exercised when considering concomitant therapy of NSAIDs and quinolones.<br />
<br />
<strong>Other NSAIDs and steroids</strong>: Co-administration of Diclofenac with other systemic NSAIDs and steroids may increase the frequency of unwanted effects. With Aspirin, the plasma levels of each are lowered, although no clinical significance is known.<br />
<br />
<strong>Diuretics:</strong>&nbsp;Various NSAIDs are liable to inhibit the activity of diuretics. Concomitant treatment with potassium-sparing diuretics may be associated with increased serum potassium levels. So, serum potassium should be monitored.</p>