<p><strong>Pediatric use:</strong>&nbsp;The safety and effectiveness of Tapentadol in pediatric patients less than 18 years of age have not been established.<br />
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<strong>Use in elderly patients:</strong>&nbsp;In general, recommended dosing for elderly patients with normal renal and hepatic function is the same as for younger adult patients with normal renal and hepatic function. consideration should be given to starting elderly patients with the lower range of recommended doses.<br />
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<strong>Use in Renal Disease:</strong>&nbsp;In patients with severe renal impairment, the safety and effectiveness of Tapentadol has not been established.<br />
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<strong>Use in Hepatic Disease</strong>: Tapentadol should be used with caution in patients with moderate hepatic impairment. Tapentadol has not been studied in patients with severe hepatic impairment.</p>