<p>The recommended initial dosage titration of Apremilast from Day 1 to Day 5 is shown below. Following the 5-day titration, the recommended maintenance dosage is 30 mg twice daily taken orally starting on Day 6. This titration is intended to reduce the gastrointestinal symptoms associated with initial therapy. Apremilast can be administered without regard to meals.<br />
<br />
<strong>Day 1</strong>: 10 mg in morning<br />
<strong>Day 2</strong>: 10 mg in morning and 10 mg in evening<br />
<strong>Day 3</strong>: 10 mg in morning and 20 mg in evening<br />
<strong>Day 4</strong>: 20 mg in morning and 20 mg in evening<br />
<strong>Day 5</strong>: 20 mg in morning and 30 mg in evening<br />
<strong>Day 6</strong>: 30 mg twice daily<br />
<br />
Dosage adjustment in patients with severe renal impairment.&nbsp;Apremilast dosage should be reduced to 30 mg once daily in patients with severe renal impairment. For initial dosage titration, it is recommended that Apremilast be titrated using only the morning schedule and the evening doses be skipped.</p>