<p>Crohn&#39;s disease:</p>

<ul>
	<li><strong>Adult:</strong>&nbsp;Initially 1-1.5 mg/kg daily, may increase to 125 mg daily.</li>
	<li><strong>Child:</strong>&nbsp;Initially 1-1.5 mg/kg daily increased to a max of 75 mg daily</li>
</ul>

<p>Acute lymphocytic leukemia:</p>

<ul>
	<li><strong>Adult:</strong>&nbsp;Usual maintenance dose: Initially, 1.5-2.5 mg/kg daily as a single dose, usually used in combination with methotrexate. Dose may vary individually based on response and tolerance. Monitor blood counts at least once wkly. Withdraw treatment immedietely if there is a sharp drop in the white cell count or severe bone-marrow depression. May resume treatment slowly and carefully if white cell count remains constant for 2-3 days or rises. Reduce dose when used with allopurinol.</li>
	<li><strong>Child:</strong>&nbsp;Usual maintenance dose: Initially, 1.5-2.5 mg/kg daily as a single dose, usually used in combination with methotrexate. Dose may vary individually based on response and tolerance. Monitor blood counts at least once wkly. Withdraw treatment immedietely if there is a sharp drop in the white cell count or severe bone-marrow depression. May resume treatment slowly and carefully if white cell count remains constant for 2-3 days or rises. Reduce dose when used with allopurinol.</li>
</ul>

<p>&nbsp;</p>

<p><strong>Administration</strong></p>

<p>Should be taken on an empty stomach. Best taken on an empty stomach 1 hr before or 2 hr after meals. Ensure adequate fluid intake.</p>