<p>Tenecteplase is for intravenous administration only. The recommended total dose should not exceed 50 mg and is based upon patient weight. A single bolus dose should be administered over 5 seconds based on patient weight. Treatment should be initiated as soon as possible after the onset of AMI symptoms.</p>

<ul>
	<li>Patient Weight &lt;60 kg: 30 mg Tenecteplase&nbsp;</li>
	<li>Patient Weight &ge;60 to &lt;70 kg: 35 mg Tenecteplase&nbsp;</li>
	<li>Patient Weight &ge;70 to &lt;80 kg: 40 mg Tenecteplase&nbsp;</li>
	<li>Patient Weight &ge;80 to &lt;90 kg: 45 mg Tenecteplase&nbsp;</li>
	<li>Patient Weight &ge;90 kg: 50 mg Tenecteplase</li>
</ul>

<p>&nbsp;</p>

<p><strong>Administration</strong></p>

<ol>
	<li>The product should be visually inspected prior to administration for particulate matter and discoloration. Tenecteplase may be administered as reconstituted at 5 mg/mL.</li>
	<li>Precipitation may occur when Tenecteplase is administered in an IV line containing dextrose. Dextrose-containing lines should be flushed with a saline-containing solution prior to and following single bolus administration of Tenecteplase.</li>
	<li>Reconstituted Tenecteplase should be administered as a single IV bolus over 5 seconds.</li>
	<li>Because Tenecteplase contains no antibacterial preservatives, it should be reconstituted immediately before use. If the reconstituted Tenecteplase is not used immediately, refrigerate the Tenecteplase vial at 2-8&deg;C and use within 8 hours.</li>
	<li>Although the supplied syringe is compatible with a conventional needle, this syringe is designed to be used with needleless IV systems. From the information below, follow the instructions applicable to the IV system in use.</li>
</ol>