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	<li>Local irritation or itching of vagina, Swelling and increased tenderness of the breasts, Increased vaginal discharge, Nausea, Fluid retention in the tissues, usually marked by swollen ankles or feet.</li>
	<li>In most patients these side effects will disappear after the first weeks of treatment. Tell your doctor if vaginal bleeding occurs or if any side effect becomes troublesome or persists.</li>
	<li>Other side effects which may occur with HRT are benign and malignant hormone-dependent tumors such as endometrial cancer, heart attack and stroke, gall bladder disease, skin problems such as rashes, discoloration or red patches on the skin, various skin diseases with blisters and nodules or bleeding into the skin, venous thromboembolism or deep leg or pelvic venous thrombosis and pulmonary embolism (see Before you use Estriol Cream). Using HRT for several years slightly increases the risk of breast cancer.</li>
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