<p><strong>Elderly (65 years and older)</strong>: Adjustment of the dose is recommended in elderly patients with compromised renal function.<br />
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<strong>Renal impairment</strong>: The daily dose must be individualized according to renal function.<br />
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<strong>Hepatic impairment</strong>: No dose adjustment is needed in patients with mild to moderate hepatic impairment. In patients with severe hepatic impairment, the creatinine clearance may underestimate renal insufficiency. Therefore a 50 % reduction of the daily maintenance dose is recommended when the creatinine clearance is &lt; 60 ml/min.</p>