<ul>
	<li><strong>Disulfiram</strong>: Psychotic reactions have been reported in patients who were using metronidazole and disulfiram concurrently.</li>
	<li><strong>Alcohol</strong>: Alcoholic beverages and drugs containing alcohol should not be consumed during therapy and for at least one day afterwards because of the possibility of a disulfiram-like (antabuse effect) reaction (flushing, vomiting, tachycardia). Oral anticoagulant therapy (warfarin type): Potentiation of the anticoagulant effect and increased hemorrhagic risk caused by decreased hepatic catabolism. In case of co-administration, prothrombin time should be more frequently monitored and anticoagulant therapy adjusted during treatment with metronidazole.</li>
	<li><strong>Lithium</strong>: Plasma levels of lithium may be increased by metronidazole.</li>
	<li><strong>Cyclosporin</strong>: Serum cyclosporin and serum creatinine should be closely monitored when co-administration is necessary.</li>
	<li><strong>Phenytoin or phenobarbital</strong>: increased elimination of metronidazole resulting in reduced plasma levels.</li>
	<li><strong>5-Fluorouracil</strong>: Reduced clearance of 5-fluorouracil resulting in increased toxicity of 5-fluorouracil.</li>
	<li><strong>Busulfan</strong>: Plasma levels of busulfan may be increased by metronidazole, which may lead to severe busulfan toxicity.</li>
</ul>