<p><strong>Adult:</strong><br />
General Anesthesia-</p>

<ul>
	<li>IV Induction: 1-4.5 mg/kg single dose</li>
	<li>IM Induction: 6.5-13mg</li>
	<li>IV Infusion: 1-2mg/kg at 0.5mg/kg/min</li>
</ul>

<p><strong>Maintenance:</strong>&nbsp;The maintenance dose should be adjusted according to the patient&#39;s anesthetic needs and whether an additional anesthetic is employed. Increments of one-half to the full induction dose may be repeated as needed for maintenance of anesthesia.<br />
<br />
Rapid sequence Intubation, Induction - 2mg/kg IV<br />
<br />
<strong>Pediatric:</strong><br />
General Anesthesia:</p>

<ul>
	<li>IV Induction: 1-2 mg/kg IV; range: 4-13 mg/kg</li>
	<li>IM Induction: 5-10 mg/kg; range: 0.5-4.5 mg/kg</li>
	<li>Maintenance: 0.01-0.03 mg/kg/min continuous IV infusion</li>
</ul>

<p><strong>Maintenance:</strong>&nbsp;The maintenance dose should be adjusted according to the patient&#39;s anesthetic needs and whether an additional anesthetic is employed. Increments of one-half to the full induction dose may be repeated as needed for maintenance of anesthesia.</p>

<p>&nbsp;</p>

<p><strong>Administration</strong></p>

<p><strong>Rate of Administration:</strong>&nbsp;It is recommended that ketamine should be administered slowly (over a period of 60 seconds). More rapid administration may result in respiratory depression and enhanced pressor response.<br />
<br />
The 100 mg/ml concentration of ketamine should not be injected intravenously without proper dilution. It is recommended the drug be diluted with an equal volume of either Sterile Water for Injection, USP, Normal Saline, or 5% Dextrose in Water.</p>