<p>Bisoprolol Hemifumarate is the most selective &szlig;1 blocker. It displays highest level of affinity for the &szlig;1 receptor than any other beta-blocker available up to now. Selectively blocks &szlig;1 adrenergic receptor in the heart and vascular smooth muscle and reduces heart rate and cardiac output resulting in decrease of arterial hypertension. Lipid metabolism can be adversely affected by &szlig;-blockers, in patients with non-&szlig;1 selective &szlig;1-blocker, but Bisoprolol does not cause any change in the cholesterol fraction including the cardioprotective HDL-cholesterol, in long-term therapy.</p>