<p><strong>Pediatric Use (2 months up to 16 years)</strong>: The maximum dose for pediatric patients should not exceed the recommended adult dose. The usual recommended dosage in pediatric patients up to 40 kg in weight for uncomplicated and complicated urinary tract infections (including pyelonephritis), uncomplicated skin and skin structure infections, and pneumonia is 50 mg/kg/dose, administered every 12 hours (50 mg/kg/dose, every 8 hours for febrile neutropenic patients), for durations as given above.<br />
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<strong>Geriatric Use</strong>: Serious adverse events have occurred in geriatric patients with renal insufficiency given unadjusted doses of cefepime, including life-threatening or fatal occurrences of the following: encephalopathy, myoclonus, and seizures. This drug is known to be substantially excreted by the kidney, and the risk of toxic reactions to this drug may be greater in patients with impaired renal function. Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and renal function should be monitored.<br />
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<strong>Impaired Hepatic Function</strong>: No adjustment is necessary for patients with impaired hepatic function.<br />
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<strong>Impaired Renal Function</strong>: In patients with impaired renal function (creatinine clearance&lt;60 ml/min), the dose of Cefepime should be adjusted to compensate for the slower rate of renal elimination.</p>