<p><strong>Patients with moderate to severe grades of renal impairment</strong>: Evidence to date shows that Prazosin does not further compromise renal function when used in patients with renal impairment. As some patients in this category have responded to small doses of Prazosin, it is recommended that therapy be initiated at 0.5 mg daily and that dosage increases be instituted cautiously.<br />
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<strong>Patients with hepatic dysfunction</strong>: it is recommended that therapy should be initiated at 0.5 mg daily and that dosage should be increased cautiously.<br />
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<strong>Use in the elderly</strong>: Since the elderly may be more susceptible to hypotension, therapy should be initiated with the lowest possible dose.</p>