<p><strong>Advanced renal cell carcinoma</strong>: 400 mg bid. May continue until patient is no longer responding or unacceptable toxicity occurs.<br />
<br />
<strong>Hepatic Impairment</strong>: No safety data is available for use in patients with Child-Pugh C hepatic impairment.</p>

<p>&nbsp;</p>

<p><strong>Administration</strong></p>

<p>Should be taken on an empty stomach. May be taken with a low or moderate fat meal. If the patient intends to have a high fat meal, sorafenib should be taken on an empty stomach at least 1 hr before or 2 hr after meals. Swallow whole, do not chew/crush.</p>