<p><strong>Adult:</strong>&nbsp;1-2 gm every 12 hour via IV injection over 3-5 minutes or infuse over 20-30 minutes.<br />
<br />
<strong>Elderly</strong>:&nbsp;There are no special precautions for its use in the elderly provided dosage is adjusted accordingly to renal function.<br />
<br />
Cefpirome is administered only through the parenteral route. The dosage is dependent upon the severity and site of infection, the susceptibility of the infecting microorganisms and age, weight and renal function of the patient. The drug is administered through intravenous injection or infusion. The following dosages are recommended for moderate to severe infections in adult patients with normal renal function:</p>

<ul>
	<li><strong>Complicated upper &amp; lower urinary tract infections</strong>: 1 gm 12 hourly.&nbsp;Total daily dose not more then 2 gm</li>
	<li><strong>Skin &amp; soft tissue infections</strong>:&nbsp;1 gm 12 hourly.&nbsp;Total daily dose not more then 2 gm</li>
	<li><strong>Lower respiratory tract infections</strong>:&nbsp;1 to 2 gm 12 hourly.&nbsp;Total daily dose not more then 2 to 4 gm</li>
	<li><strong>Bacteraemia or septicaemia and severe infections</strong>: 2&nbsp;gm 12 hourly.&nbsp;Total daily dose not more then 4 gm</li>
	<li><strong>Infections in neutropenic patients</strong>:&nbsp;2&nbsp;gm 12 hourly.&nbsp;Total daily dose not more then 4 gm</li>
</ul>

<p>Dose reduction is necessary in patients with markedly reduced renal function. After an initial dose of 0.5 -2 gm to establish a high serum concentration, the dose should be reduced by 50% for clearances of 49-21 ml/min or 75% for clearances of 20 ml/min. In end-stage renal disease, a supplementary dose equal to 50% of the recommended daily dose should be administered after each hemodialysis<br />
treatment.</p>