<p>The most common adverse reactions reported in &ge;5% of patients simultaneously started on sitagliptin and metformin and more commonly than in patients treated with placebo were diarrhea, upper respiratory tract infection, and headache.<br />
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Adverse reactions reported in &ge;5% of patients treated with sitagliptin in combination with sulfonylurea and metformin and more commonly than in patients treated with placebo in combination with sulfonylurea and metformin were hypoglycemia and headache.<br />
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Hypoglycemia was the only adverse reaction reported in &ge;5% of patients treated with sitagliptin in combination with insulin and metformin and more commonly than in patients treated with placebo in combination with insulin and metformin.<br />
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Nasopharyngitis was the only adverse reaction reported in &ge;5% of patients treated with sitagliptin monotherapy and more commonly than in patients given placebo.<br />
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The most common (&gt;5%) adverse reactions due to initiation of metformin therapy are diarrhea, nausea/vomiting, fatulence, abdominal discomfort, indigestion, asthenia, and headache.</p>