<p><strong>With medicine</strong>: Drugs or herbal products that induce certain enzymes, including CYP3A4 may decrease the effectiveness of COCs or increase breakthrough bleeding. Counsel patients to use a back-up method or alternative method of contraception when enzyme inducers are used with COCs.<br />
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<strong>With food and other</strong>: It is recommended to avoid caffeine, dairy foods, phytic acid containing food while taking the drug.</p>