<p>Patients with congenital or documented acquired QT prolongation, patients with refractory hypokalemia or hypomagnesemia, or those on concomitant therapy with other drugs that prolong the QT interval.<br />
<br />
Saquinavir is contraindicated in patients with complete atrioventricular (AV) block without implanted pacemakers, or patients who are at high risk of complete AV block.<br />
<br />
Saquinavir is contraindicated in patients with clinically significant hypersensitivity (e.g., anaphylactic reaction, Stevens-Johnson syndrome) to saquinavir, saquinavir mesylate, or any of its ingredients<br />
<br />
Saquinavir when administered with ritonavir is contraindicated in patients with severe hepatic impairment.<br />
<br />
Coadministration of Saquinavir/ritonavir with CYP3A substrates for which increased plasma levels may result in serious or life-threatening reactions.<br />
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Coadministration of Saquinavir/ritonavir with rifampin due to the risk of severe hepatotoxicity.</p>