<p>Dosage Adjustment for Patients With Impaired Renal Function: The dosage recommendation is the same as for the general population.<br />
<br />
Dosage Adjustment for Patients With Impaired Hepatic Function: In patients with severe hepatic impairment, a single maximal daily dose of 8 mg to be infused over 15 minutes beginning 30 minutes before the start of the emetogenic chemotherapy is recommended.<br />
<br />
Little information is available about dosage in pediatric patients 4 years of age or younger.<br />
<br />
Dosage adjustment is not needed in patients over the age of 65.</p>