<p><strong>Dosage Modifications for Severe Renal Impairment</strong>: The recommended dosage of Lenvatinib for patients with DTC, RCC, or endometrial carcinoma and severe renal impairment (creatinine clearance less than 30 mL/min calculated by Cockcroft-Gault equation using actual body weight) is:</p>

<ul>
	<li>Differentiated thyroid cancer: 14 mg orally once daily</li>
	<li>Renal cell carcinoma: 10 mg orally once daily</li>
	<li>Endometrial carcinoma: 10 mg orally once daily</li>
</ul>

<p><strong>Dosage Modifications for Severe Hepatic Impairment</strong>: The recommended dosage of Lenvatinib for patients with DTC, RCC, or endometrial carcinoma and severe hepatic impairment (Child-Pugh C) is:</p>

<ul>
	<li>Differentiated thyroid cancer: 14 mg taken orally once daily</li>
	<li>Renal cell carcinoma: 10 mg taken orally once daily</li>
	<li>Endometrial carcinoma: 10 mg orally once daily Or as directed by the registered physician.</li>
</ul>

<p><strong>Pediatric Use</strong>: The safety and effectiveness in pediatric patients have not been established.</p>