<p>Clomipramine hydrochloride belongs to a group of medicines called &quot;tricyclic antidepressants&quot;. This is thought to work either by increasing the amount of chemical &quot;messengers&quot; in the brain or by making their effects last longer. Clomipramine is a potent inhibitor of serotonin re-uptake in the brain. Significant antagonism at cholinergic and &alpha;1-receptors. Weak antagonism at dopamine receptors. It has also antidepressant, sedative and anticholinergic effects.</p>