<p>Tenecteplase therapy in patients with acute myocardial infarction is contraindicated in the following situations because of an increased risk of bleeding:</p>

<ul>
	<li>Active internal bleeding</li>
	<li>History of cerebrovascular accident</li>
	<li>Intracranial or intraspinal surgery or trauma within 2 months</li>
	<li>Intracranial neoplasm, arteriovenous malformation, or aneurysm</li>
	<li>Known bleeding diathesis</li>
	<li>Severe uncontrolled hypertension</li>
</ul>