<p>The maximum tolerated dose of etanercept has not been established in humans. Single intravenous doses up to 60 mg/m2&nbsp;have been administered to healthy volunteers in an endotoxemia study without evidence of dose-limiting toxicities. The highest dose level evaluated in rheumatoid arthritis patients has been an intravenous loading dose of 32 mg/m2&nbsp;followed by subcutaneous doses of 16 mg/m2&nbsp;(25 mg) administered twice weekly. No dose-limiting toxicities were observed during clinical trials of rheumatoid arthritis patients. There is no known antidote to etanercept.</p>