<p>Usual Adult Dose for Tuberculosis: Active:</p>

<p>15 to 30 mg/kg (up to 2 g) orally once a day in combination with three other antituberculous drugs for the initial 2 months of a 6-month or 9-month treatment regimen, until drug susceptibility tests are known. An alternate dosing regimen of 50 to 75 mg/kg (up to 3 g) orally twice a week may be used after 2 weeks of daily therapy to increase patient compliance.<br />
<br />
Alternatively, the CDC, The American Thoracic Society, and the Infectious Diseases Society of America suggest the following dosing based on estimated lean body weight:<br />
<br />
Daily dosing:</p>

<ul>
	<li><strong>40 to 45 kg</strong>: 1000 mg</li>
	<li><strong>56 to 75 kg</strong>: 1500 mg</li>
	<li><strong>76 to 90 kg</strong>: 2000 mg</li>
</ul>

<p>Twice weekly dosing:</p>

<ul>
	<li><strong>40 to 55 kg</strong>: 2000 mg</li>
	<li><strong>56 to 75 kg</strong>: 3000 mg</li>
	<li><strong>76 to 90 kg</strong>: 4000 mg</li>
</ul>

<p>Thrice weekly dosing:</p>

<ul>
	<li><strong>40 to 55 kg</strong>: 1500 mg</li>
	<li><strong>56 to 75 kg</strong>: 2500 mg</li>
	<li><strong>76 to 90 kg</strong>: 3000 mg</li>
</ul>

<p><br />
Usual Adult Dose for Tuberculosis: Latent:&nbsp;</p>

<p>A public health expert should be consulted prior to the use of the combination regimen with rifampin.<br />
<br />
15 to 20 mg/kg, based on actual body weight (lean), orally once daily (maximum 2 g) for 2 months. Alternatively, a dosage of 50 mg/kg may be administered orally twice-weekly (maximum 4 g).</p>

<p><br />
Usual Pediatric Dose for Tuberculosis: Active:</p>

<p>(Used as part of a multidrug regimen. Treatment regimens consist of an initial 2-month phase, followed by a continuation phase of 4 or 7 additional months. Frequency of dosing may differ depending on phase of therapy)<br />
<br />
Infants, Children less than 40 kg and Adolescents 14 years and younger and less than 40 kg:<br />
Non-HIV patients:</p>

<ul>
	<li><strong>Daily therapy</strong>: 15 to 30 mg/kg/dose (maximum: 2 g/dose) once daily</li>
	<li><strong>Directly observed therapy (DOT)</strong>: 50 mg/kg/dose (maximum: 2 g/dose) twice weekly</li>
</ul>

<p>HIV-exposed/infected patients:</p>

<ul>
	<li><strong>Daily therapy</strong>: 20 to 40 mg/kg/dose once daily (maximum: 2 g/day)</li>
</ul>

<p>&nbsp;</p>