<p>Administer by intravenous infusion based upon recommended infusion rate for each indication.<br />
<br />
<strong>Unresectable or metastatic melanoma</strong>:</p>

<ul>
	<li>240 mg every 2 weeks or 480 mg every 4 weeks.</li>
	<li>1 mg/kg followed by ipilimumab 3 mg/kg on the same day every 3 weeks for 4 doses, then 240 mg every 2 weeks or 480 mg every 4 weeks.</li>
</ul>

<p><strong>Adjuvant treatment of melanoma</strong>: 240 mg every 2 weeks or 480 mg every 4 weeks.<br />
<br />
<strong>Metastatic non-small-cell lung cancer</strong>:</p>

<ul>
	<li>3 mg/kg every 2 weeks with ipilimumab 1 mg/kg every 6 weeks.</li>
	<li>360 mg every 3 weeks with ipilimumab 1 mg/kg every 6 weeks and 2 cycles of platinum-doublet chemotherapy.</li>
	<li>240 mg every 2 weeks or 480 mg every 4 weeks.</li>
</ul>

<p><strong>Malignant pleural mesothelioma</strong>: 360 mg every 3 weeks with ipilimumab 1 mg/kg every 6 weeks.<br />
<br />
<strong>Advanced renal cell carcinoma</strong>:</p>

<ul>
	<li>3 mg/kg followed by ipilimumab 1 mg/kg on the same day every 3 weeks for 4 doses, then 240 mg every 2 weeks or 480 mg every 4 weeks.</li>
	<li>240 mg every 2 weeks or 480 mg every 4 weeks administered in combination with cabozantinib 40 mg once daily without food.</li>
	<li>240 mg every 2 weeks or 480 mg every 4 weeks.</li>
</ul>

<p><strong>Classical Hodgkin lymphoma</strong>: 240 mg every 2 weeks or 480 mg every 4 weeks.<br />
<br />
<strong>Recurrent or metastatic squamous cell carcinoma of the head and neck</strong>: 240 mg every 2 weeks or 480 mg every 4 weeks.<br />
<br />
<strong>Locally advanced or metastatic urothelial carcinoma</strong>: 240 mg every 2 weeks or 480 mg every 4 weeks.<br />
<br />
<strong>Microsatellite instability-high (MSI-H) or mismatch repair deficient (dMMR) metastatic colorectal cancer</strong>:</p>

<ul>
	<li>Adult and pediatric patients &ge;40 kg: 240 mg every 2 weeks or 480 mg every 4 weeks.</li>
	<li>Pediatric patients &lt;40 kg: 3 mg/kg every 2 weeks.</li>
	<li>Adult and pediatric patients &ge;40 kg: 3 mg/kg followed by ipilimumab 1 mg/kg on the same day every 3 weeks for 4 doses, then 240 mg every 2 weeks or 480 mg every 4 weeks.</li>
</ul>

<p><strong>Hepatocellular carcinoma</strong>:</p>

<ul>
	<li>240 mg every 2 weeks or 480 mg every 4 weeks.</li>
	<li>1 mg/kg followed by ipilimumab 3 mg/kg on the same day every 3 weeks for 4 doses, then 240 mg every 2 weeks or 480 mg every 4 weeks.</li>
</ul>

<p><strong>Esophageal squamous cell carcinoma</strong>: 240 mg every 2 weeks or 480 mg every 4 weeks.<br />
<br />
<strong>Gastric cancer, gastroesophageal junction cancer, and esophageal adenocarcinoma (GC, GEJC, or EAC)</strong>:</p>

<ul>
	<li>360 mg every 3 weeks with fluoropyrimidine- and platinum-containing chemotherapy every 3 weeks.</li>
	<li>240 mg every 2 weeks with fluoropyrimidine- and platinum-containing chemotherapy every 2 weeks.</li>
</ul>