<p>Renal Impairment:</p>

<ul>
	<li><strong>CrCl &lt;20 and patients on haemodialysis or peritoneal dialysis</strong>: 100 mg 24 hrly following usual initial dose.</li>
	<li><strong>CrCl 20-50</strong>: Reduce dose by half 24 hrly following usual initial dose.</li>
</ul>

<p>Hepatic Impairment:Severe: Reduce dose. Max: 400 mg daily</p>