<p><strong>Pediatric Use</strong>: The safety and effectiveness of Abemaciclib have not been established in pediatric patients.<br />
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<strong>Geriatric Use</strong>: No overall differences in safety or effectiveness of Abemaciclib were observed between these patients and younger patients.<br />
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<strong>Renal Impairment</strong>: No dosage adjustment is required for patients with mild or moderate renal impairment.<br />
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<strong>Hepatic Impairment</strong>: No dosage adjustments are necessary in patients with mild or moderate hepatic impairment</p>