<p><strong>Previously untreated patients</strong>: 400 mg/m2&nbsp;as single short term IV infusion over 15-60 min. Therapy should not be repeated until 4 wk after the previous course and/or until the neutrophil count is at least 2,000 cells/mm3&nbsp;and the platelet count is at least 100,000 cells/mm3.<br />
<br />
<strong>Patients previously treated with myelosuppresive therapy or patients with poor performance status</strong>: Reduce initial dosage by 20-25% (300-320 mg/m2).</p>