<p>The most common adverse reactions at the site of topical application were dry lips, desquamation, dryness of skin, cracked lips, burning skin, pruritus, flakiness of skin, and stinging on skin; each adverse reaction occurred in less than 1% of patients receiving Acyclovir&nbsp;cream and placebo. Three patients on Acyclovir&nbsp;cream and one patient on placebo discontinued treatment due to an adverse event.</p>