<p>Vaccination must be postponed in cases of moderate or severe febrile and/or acute disease; the administration of Hexaxim must be carefully considered in individuals who have a history of serious or severe reactions within 48 hours following administration of a vaccine containing similar components. As with all injectable vaccines, the vaccine must be administered with caution to subjects with thrombocytopenia or a bleeding disorder since bleeding may occur following an intramuscular administration. If any of the following events are known to have occurred after receiving any pertussis-containing vaccine, the decision to give further doses of pertussis containing vaccine should be carefully considered:</p>

<ul>
	<li>The temperature of &ge;40&deg;C within 48 hours not due to another identifiable cause;</li>
	<li>Collapse or shock-like state (hypotonic-hyporesponsive episode) within 48 hours of vaccination;</li>
	<li>Persistent, inconsolable crying lasting &ge; 3 hours, occurring within 48 hours of vaccination;</li>
	<li>Convulsions with or without fever, occurring within 3 days of vaccination. Take special care in case of Guillain Barr&eacute; Syndrome, Brachial neuritis, acute or chronic renal insufficiency, epilepsy.</li>
</ul>