<p><strong>Paediatric Use</strong>: Safety and effectiveness in paediatric patients have not been established.<br />
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<strong>Geriatric Use</strong>: No overall differences in safety and efficacy have been observed between the elderly and younger individuals, and other reported clinical experience has not identified differences in responses between the elderly and younger patients, but greater sensitivity of some older individuals cannot be ruled out<br />
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<strong>Hepatic Insufficiency</strong>: No dosage adjustment is recommended for patients with mild to moderate hepatic insufficiency. However, in patients with severe hepatic insufficiency, a dose of 20 mg once daily should not be exceeded.<br />
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<strong>Renal Insufficiency</strong>: The Pharmacokinetics of Esomeprazole in patients with renal impairment are not expected to be altered relative to healthy volunteers as less than 1% of Esomeprazole is excreted unchanged in the urine.</p>