<p><strong>Patient with renal impairment</strong>: Sulindac should be administered with caution to patients with impaired renal function and to those with bleeding disorders, epilepsy, parkinsonism or psychiatric disorders.<br />
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<strong>Patient with hepatic impairment</strong>: In the presence of liver function impairment the half life of Sulindac is prolonged and a reduction of daily dosage may be required.</p>