<p><strong>Pregnancy</strong>:&nbsp;Bosentan is contraindicated in pregnancy.<br />
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<strong>Use during lactation</strong>: lt is not known whether bosentan is excreted into human breast milk. Breast-feeding is not recommended during treatment with Bosentan.<br />
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<strong>Effects on ability to drive and use machines</strong>:&nbsp;Bosentan may cause dizziness, which could affect the ability to drive or use machines.</p>