<p><strong>Potentiation of Vascular Insufficiency</strong>: Brimonidine Tartrate may potentiate syndromes associated with vascular insufficiency. Brimonidine Tartrate should be used with caution in patients with depression, cerebral or coronary insufficiency, Raynaud&rsquo;s phenomenon, orthostatic hypotension, or thromboangiitis obliterans.<br />
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<strong>Severe Cardiovascular Disease</strong>: Although brimonidine tartrate ophthalmic solution had minimal effect on the blood pressure of patients in clinical studies, caution should be exercised in treating patients with severe cardiovascular disease.<br />
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<strong>Contamination of Topical Ophthalmic Products After Use</strong>: There have been reports of bacterial keratitis associated with the use of multiple-dose containers of topical ophthalmic products. These containers had been inadvertently contaminated by patients who, in most cases, had a concurrent corneal disease or a disruption of the ocular epithelial surface</p>