<ul>
	<li>Aminocaproic acid should not be used when there is evidence of an active intravascular clotting process.</li>
	<li>When there is uncertainty as to whether the cause of bleeding is primary fibrinolysis or disseminated intravascular coagulation (DIC), this distinction must be made before administering Aminocaproic acid Injection.</li>
	<li>The following tests can be applied to differentiate the two conditions:</li>
	<li>Platelet count is usually decreased in DIC but normal in primary fibrinolysis.</li>
	<li>Protamine paracoagulation test is positive in DIC; a precipitate forms when protamine sulfate is dropped into citrated plasma. The test is negative in the presence of primary fibrinolysis.</li>
	<li>The euglobulin clot lyses test is abnormal in primary fibrinolysis but normal in DIC.</li>
	<li>Aminocaproic acid Injection must not be used in the presence of DIC without concomitant heparin.</li>
</ul>