<p><strong>Extract of Allium cepa</strong>: It is derived from the membrane of Allium cepa (onion membrane). It shows antiphlogistic efects through inhibition of infammatory mediators&rsquo; secretion and anti-allergenic efect. Extract of Allium cepa inhibits growth of fbroblast of diferent origin, particularly kelloidal fbroblasts. It has also bactericidal efect. While these properties stimulate primary wound healing, it prevents non-physiological scar formation.<br />
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<strong>Heparin</strong>: In case of local application, it shows inhibitory efect on fbroblast proliferation. While heparin increases tissue hydration, it reduces irritation resulted from induration and infammation.<br />
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<strong>Allantoin</strong>: Allantoin stimulates cellular proliferation. It also supports the development of healthy cells. Allantoin is convenient substance for the treatment of scar through its properties of stimulating epithelization and providing elastic surface formation.<br />
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Clinical studies:</p>

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	<li><strong>Evaluation of the use of Extract of Allium cepa, Heparin &amp; Allantoin gel for the prevention of scar formation</strong>: Total 1,268 patients were evaluated and after 2 to 3 months of treatment with Extract of Allium cepa, Heparin &amp; Allantoin gel, a reduction of 31.5% in mean scar width and 47.8% reduction of mean scar height at the end of the observation period.</li>
	<li><strong>Assessment of the use of Extract of Allium cepa, Allantoin, and Heparin in the early treatment of C-section scars</strong>: A total of 61 females, aged &ge;18 years, who had given birth by C-section were evaluated. After six weeks of treatment, the gel showed signifcant improvement of the color, stifness and irregularity of C-section scars.</li>
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