<p>Dose-limiting toxicity includes myelosuppression and cardiotoxicity. Other reactions include:</p>

<ul>
	<li><strong>Cutaneous</strong>: Reversible alopecia occurs in most patients. Rash, contact dermatitis and urticaria have occurred rarely.</li>
	<li><strong>Gastrointestinal</strong>: Acute nausea and vomiting occur but are usually mild. Antiemetic therapy may be of some help. Mucositis may occur 3 to 7 days after administration. Diarrhea and abdominal pain have occasionally been reported.</li>
	<li><strong>Local</strong>: If extravasation occurs during administration, severe local tissue necrosis, severe cellulitis, thrombophlebitis or painful induration can result.</li>
	<li><strong>Acute Reactions</strong>: Rarely, anaphylactoid reaction, fever, and chills can occur. Hyperuricemia may occur, especially in patients with leukemia, and serum uric acid levels should be monitored.</li>
</ul>