<p>The following clinical conditions require special caution and frequent patient monitoring is necessary-</p>

<ul>
	<li>Cardiac disease or congestive heart failure (except in the presence of active rheumatic carditis), hypertension, thromboembolic disorders. Glucocorticoids can cause salt and water retention and increased excretion of potassium. Dietary salt restriction and potassium supplementation may be necessary.</li>
	<li>Gastritis or oesophagitis, diverticulitis, ulcerative colitis if there is the probability of impending perforation, abscess or pyogenic infections, fresh intestinal anastomosis, active or latent peptic ulcer.</li>
	<li>Diabetes mellitus or family history, osteoporosis, myasthenia gravis, renal insufficiency.</li>
	<li>Emotional instability or psychotic tendency, epilepsy.</li>
	<li>Previous corticosteroid-induced myopathy.</li>
	<li>Liver failure.</li>
	<li>Hypothyroidism and cirrhosis, which may increase the glucocorticoid effect.</li>
	<li>Ocular herpes simplex because of possible corneal perforation.</li>
</ul>