<p><strong>Gastric acid reducing agents</strong>: Avoid concomitant use with proton pump inhibitors (PPI) and H2-receptor antagonists. Separate Neratinib by 3 hours after antacid dosing.<br />
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<strong>Strong or moderate CYP3A4 inhibitors</strong>: Avoid concomitant use.<br />
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<strong>Strong or moderate CYP3A4 inducers</strong>: Avoid concomitant use.&nbsp;<br />
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<strong>P-glycoprotein (P-gp) substrates</strong>: Monitor for adverse reactions of narrow therapeutic agents that are P-gp substrates when used concomitantly with Neratinib.</p>