<p>The following agents have been shown to influence the magnitude and/or duration of action of non-depolarizing neuromuscular blocking agents:<br />
&nbsp;</p>

<p><strong>Effect of Other Agents on Vecuronium:</strong></p>

<p><strong>Increased Effect:</strong></p>

<ul>
	<li>Halogenated volatile anaesthetics potentiate the neuromuscular block of Vecuronium. The effect only becomes apparent with maintenance dosing (see also Dosage and Administration). Reversal of the block with anticholinesterase inhibitors could also be inhibited.&nbsp;</li>
	<li>After intubation with suxamethonium</li>
	<li>Long-term concomitant use of corticosteroids and Vecuronium in the ICU may result in prolonged duration of neuromuscular block or myopathy.</li>
</ul>

<p>Other medicines:</p>

<ul>
	<li>antibiotics: aminoglycoside, lincosamide and polypeptide antibiotics, acylaminopenicillin antibiotics,&nbsp;</li>
	<li>diuretics, quinidine, magnesium salts, calcium channel blocking agents, lithium salts, cimetidine, lidocaine and acute administration of phenytoin or &beta;-blocking agents&nbsp;</li>
	<li>Recurarization has been reported after post-operative administration of: aminoglycoside, lincosamide, polypeptide and acylamino-penicillin antibiotics, quinidine and magnesium salts</li>
</ul>

<p><strong>Decreased Effect</strong>&nbsp;(possible higher dose requirements):</p>

<ul>
	<li>prior chronic administration of phenytoin or carbamazepine&nbsp;</li>
	<li>Variable Effect</li>
	<li>Administration of other non-depolarizing neuromuscular blocking agents in combination with Vecuronium may produce attenuation or potentiation of the neuromuscular block, depending on the order of administration and the neuromuscular blocking agent used.&nbsp;</li>
	<li>Suxamethonium given after the administration of Vecuronium may produce potentiation or attenuation of the neuromuscular blocking effect of Vecuronium.&nbsp;</li>
</ul>

<p>&nbsp;</p>

<p><strong>Effect of Vecuronium on other agents:</strong></p>

<p>Effect of Vecuronium on lidocaine: Vecuronium combined with lidocaine may result in a quicker onset of action of lidocaine.</p>