<ul>
	<li>Memantine and donepezil hydrochlorides extended-release is likely to exaggerate succinylcholine-type muscle relaxation during anesthesia.</li>
	<li>Memantine and donepezil hydrochlorides extended-release may have vagotonic effects on the sinoatrial and atrioventricular nodes manifesting as bradycardia or heart block.</li>
	<li>Monitor patients for symptoms of active or occult gastrointestinal bleeding, especially those at increased risk for developing ulcers.</li>
	<li>Memantine and donepezil hydrochlorides extended-release can cause diarrhea, nausea, and vomiting.</li>
	<li>Memantine and donepezil hydrochlorides extended-release may cause bladder outflow obstructions.</li>
	<li>Conditions that raise urine pH may decrease the urinary elimination of memantine, resulting in increased plasma levels of memantine.</li>
</ul>