<p><strong>Renal impairment</strong>: Chlorthalidone dosage should be reduced in moderate renal failure - every 24 or 48 h - and should not be used in advanced renal failure.<br />
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<strong>Liver disease</strong>: There is a risk of precipitating hepatic encephalopathy in patients with liver cirrhosis and ascites.<br />
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<strong>Use in pregnancy</strong>: It is better to avoid Chlorthalidone as it crosses the placenta.<br />
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<strong>Use in Lactation</strong>: In lactating mother, significant amount of Chlorthalidone enter breast milk; like other long-acting thiazides, it can suppress lactation. Chlorthalidone should not be prescribed for lactating mother.</p>