<p>Smoking cessation therapies are more likely to succeed for patients who are motivated to stop smoking and who are provided additional advice and support. Provide patients with appropriate educational materials and counseling to support the quit attempt.<br />
<br />
The patient should set a date to stop smoking. Begin Varenicline dosing one week before this date. Alternatively, the patient can begin Varenicline dosing and then quit smoking between days 8 and 35 of treatment.<br />
<br />
The recommended dose of Varenicline is 1 mg twice daily following a 1-week titration as follows:</p>

<ul>
	<li><strong>Days 1-3</strong>: 0.5 mg once daily</li>
	<li><strong>Days 4-7</strong>: 0.5 mg twice daily</li>
	<li><strong>Day 8-end of treatment</strong>: 1 mg twice daily</li>
</ul>

<p>Patients should be treated with Varenicline for 12 weeks. For patients who have successfully stopped smoking at the end of 12 weeks, an additional course of 12 weeks treatment with Varenicline is recommended to further increase the likelihood of long-term&nbsp;abstinence.<br />
<br />
For patients who are sure that they are not able or willing to quit abruptly, consider a gradual approach to quitting smoking with Varenicline. Patients should begin Varenicline dosing and reduce smoking by 50% from baseline within the first four weeks, by an additional 50% in the next four weeks, and continue reducing with the goal of reaching complete abstinence by 12 weeks. Continue Varenicline treatment for an additional 12 weeks, for a total of 24 weeks of treatment. Encourage patients to attempt quitting sooner if they feel ready<br />
<br />
Patients who are motivated to quit, and who did not succeed in stopping smoking during prior Varenicline therapy for reasons other than intolerability due to adverse events or who relapsed after treatment, should be encouraged to make another attempt with Varenicline once factors contributing to the failed attempt have been identified and addressed.<br />
<br />
Consider a temporary or permanent dose reduction in patients who cannot tolerate the adverse effects of Varenicline.</p>

<p>&nbsp;</p>

<p><strong>Administration</strong></p>

<p>Varenicline should be taken orally after eating and with a full glass of water.</p>