<p><strong>Usual Adult Dose for Anemia Associated with Chronic Renal Failure:</strong></p>

<p>Chronic Kidney Disease (CKD) Patients Not on Dialysis:</p>

<ul>
	<li><strong>Initial dose</strong>: 0.45 mcg/kg IV or subcutaneously once every 4 weeks as appropriate</li>
	<li><strong>Comments</strong>: Initiate treatment only when hemoglobin is less than 10 g/dL, rate of hemoglobin decline indicates likelihood of requiring RBC transfusion, and reducing risk of alloimmunization and/or other RBC transfusion-related risks is a goal.</li>
</ul>

<p>CKD Patients on Dialysis:</p>

<ul>
	<li><strong>Initial dose</strong>: 0.45 mcg/kg IV or subcutaneously once a week or 0.75 mcg/kg once every 2 weeks as appropriate</li>
	<li><strong>Comments</strong>: Initiate treatment when hemoglobin is less than 10 g/dL. IV route is recommended for patients on hemodialysis.</li>
</ul>

<p>&nbsp;</p>

<p><strong>Usual Adult Dose for Anemia Associated with Chemotherapy:</strong></p>

<ul>
	<li><strong>Initial dose</strong>: 2.25 mcg/kg subcutaneously once a week or 500 mcg subcutaneously once every 3 weeks</li>
	<li><strong>Duration of therapy</strong>: Until completion of chemotherapy course</li>
	<li><strong>Comments</strong>: Initiate treatment if hemoglobin is less than 10 g/dL and a minimum of 2 additional months of chemotherapy is planned. Use the lowest dose necessary to avoid RBC transfusions.</li>
	<li><strong>Use</strong>: Treatment of anemia in patients with non-myeloid malignancies where anemia is due to the effect of concomitant myelosuppressive chemotherapy.</li>
</ul>