<p>Limited data are available with regard to overdosage in human subjects with this tablet. In healthy volunteers, a single dose of this tablet&nbsp;583 mg sacubitril/617 mg valsartan, and multiple doses of 437 mg sacubitril/463 mg valsartan (14 days) have been studied and were well tolerated. Hypotension is the most likely result of overdosage due to the blood-pressure-lowering&nbsp;effects of this tablet. Symptomatic treatment should be provided. This tablet&nbsp;is unlikely to be removed by hemodialysis because of high protein binding.</p>