<p><strong>Pregnancy</strong>&nbsp;Category C. Salsalate and salicylic acid have been shown to be&nbsp;teratogenic&nbsp;and embryocidal in rats when given in doses 4 to 5 times the usual human dose. The effects were not observed at doses twice as great as the usual human dose. There are no adequate and well-controlled studies in&nbsp;pregnantwomen. Salsalate should be used during pregnancy only if the potential benefit justifies the potential risk to the&nbsp;fetus.<br />
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<strong>Nursing Mothers</strong>: It is not known whether salsalate per se is excreted in human milk; salicylic acid, the primary metabolite of Salsalate , has been shown to appear in human milk in concentrations approximating the maternal&nbsp;blood&nbsp;level. Thus, the infant of a mother on Salsalate&nbsp;therapy&nbsp;might ingest in mother&dagger;s milk 30 to 80% as much salicylate per kg body weight as the mother is taking. Accordingly, caution should be exercised when Salsalate is administered to a nursing woman.</p>