<p><strong>Adults</strong>: The usual dose of Aztreonam is 3 to 4 gm daily (maximum recommended dose is 8 gm daily). The dosage and route of administration should be determined by the susceptibility of the causative organisms, severity of infection and the condition of the patient. In case of Pseudomonas aeruginosa infections, 2 gm every 6 or 8 hours is recommended.<br />
<br />
<strong>Children</strong>: The usual dosage for patients older than one week is 30 mg/kg/dose every 6 or 8 hours. For severe infections in patients 2 years of age or older, 50 mg/kg/dose every 6 or 8 hours is recommended.Dosage information is not yet available for new-born less than 1 week old.<br />
<br />
<strong>Dosage Guideline for adult:</strong></p>

<ul>
	<li>Urinary tract infections: 500 mg or 1 gm; 8 or 12 hourly</li>
	<li>Moderately severe systemic infections: 1 g or 2 gm; 8 or 12 hourly</li>
	<li>Severe systemic or life-threatening infections: 2 gm; 6 or 8 hourly</li>
	<li>Maximum recommended dose is 8 gm/ day.</li>
</ul>

<p><strong>Dosage Guideline or pediatric:</strong></p>

<ul>
	<li>Mild to moderate infections: 30 mg/kg; 8 hourly</li>
	<li>Moderate to severe infections (2 years or older): 50 mg/kg; 6 or 8 hourly</li>
	<li>Maximum recommended dose is 120 mg/ kg/ day.</li>
</ul>

<p>&nbsp;</p>

<p><strong>Administration</strong></p>

<p><strong>Intramuscular administration</strong>: The dose should be given by deep injection into a large muscle mass. Aztreonam is well tolerated and should not be administered with any local anesthetic agent. For each gram of Aztreonam add at least 3 ml water for injection BP and shake well.<br />
<br />
<strong>Intravenous administration</strong>: A bolus injection may be used to initiate therapy. The dose should be slowly injected directly into a vein, or the tubing of a suitable administration set, over a period of 3 to 5 minutes.<br />
<br />
<strong>For infusion</strong>: Each gram of Aztreonam should be initially constituted with at least 3 ml of water for injection BP. The resulting solution should be diluted with an appropriate infusion solution to a final concentration not exceeding 2% w/v (at least 50 ml solution per gram Aztreonam). The Aztreonam infusion should be administered over a 20-60 minute period. A number of intravenous solutions may be used as diluents for the administration of Aztreonam by intravenous infusion.These include sodium chloride injection, dextrose and mixed injections of sodium chloride and dextrose, Ringers and lactated Ringers injection,water for injection etc.</p>