<p><strong>Carbamazepine</strong>: Based on individual response, the dose of Eslicarbazepine acetate may need to be increased if used concomitantly with carbamazepine.<br />
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<strong>Phenytoin</strong>: The dose of Eslicarbazepine acetate may need to be increased and the dose of phenytoin may need to be decreased.<br />
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<strong>Oral contraceptives</strong>: Administration of Eslicarbazepine acetate 1,200 mg once daily to female subjects using a combined oral contraceptive showed an average decrease of 37% and 42% in systemic exposure to levonorgestrel and ethinyloestradiol, respectively. Therefore, women of childbearing potential must use adequate contraception during treatment with Eslicarbazepine acetate.<br />
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<strong>Simvastatin</strong>: The dose of Simvastatin shall be increased if used with Eslicarbazepine.</p>