<p><strong>Hepatic impairment</strong>: Budesonide and formoterol fumarate systemic exposure may increase in patients with severe hepatic impairment. Monitor patients for signs of increased drug exposure.<br />
<br />
<strong>Renal impairment</strong>: In patients with severe renal impairment, use should be considered only if the potential benefit of the treatment outweighs the risk.<br />
<br />
<strong>Pediatric Use</strong>: This is not indicated for use in children. The safety and effectiveness of this spray&nbsp;have not been established in pediatric patients.<br />
<br />
<strong>Geriatric Use</strong>: Based on available data, no adjustment of the dosage of This in geriatric patients is necessary, but greater sensitivity in some older individuals cannot be ruled out.</p>