<p>Rarely (&ge;1/10,000 to &le;1/1,000), skin reactions such as rash, pruritus, urticaria or injection site reactions may occur. In very rare cases (&le;1/10,000) anaphylactoid reactions have been reported. However, in controlled clinical studies no increased incidence of hypersensitivity reactions was found. In very rare cases (&le;1/10,000), particularly when starting treatment, flu-like symptoms such as fever, chills, headaches, pain in the limbs, malaise and/or bone pain have been reported. These reactions were mild or moderate in nature and subsided after a couple of hours or days.</p>