<p>Treatment of overdose with Sunitinib should consist of general supportive measures. There is no specific&nbsp;antidote&nbsp;for overdosage with Sunitinib. If indicated, elimination of unabsorbed drug should be achieved by&nbsp;emesis&nbsp;or&nbsp;gastric&nbsp;lavage. Cases of accidental overdose have been reported; these cases were associated with adverse reactions consistent with the known safety profile of Sunitinib, or without adverse reactions. A case of intentional overdose involving the ingestion of 1,500 mg of Sunitinib in an attempted suicide was reported without adverse reaction. In non-clinical studies mortality was observed following as few as 5 daily doses of 500 mg/kg (3000 mg/m&sup2;) in rats. At this dose, signs of toxicity included impaired muscle coordination, head shakes, hypoactivity, ocular discharge,&nbsp;piloerection&nbsp;and gastrointestinal distress. Mortality and similar signs of toxicity were observed at lower doses when administered for longer durations.</p>