<p><strong>General</strong>: Drugs having anticholingeric properties should be used with caution in patients with narrow-angle&nbsp;glaucoma, prostatic&nbsp;hypertrophy, stenosing&nbsp;peptic ulcer, pyloroduodenal obstruction, and bladder-neck obstruction. Promethazine hydrochloride (promethazine hydrochloride injection) should be used cautiously in persons with&nbsp;cardiovascular disease&nbsp;or impairment of liver function.<br />
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<strong>Carcinogenesis, Mutagenesis&nbsp;</strong>and<strong>&nbsp;Impairment of Fertility</strong>: Long term animal studies have not been performed to assess the carcinogenic potential of promethazine hydrochloride (promethazine hydrochloride injection), nor are there other animal or human data concerning carcinogenicity, mutagenicity, or impairment of fertility. Promethazine hydrochloride was nonmutagenic in the Ames&nbsp;Salmonella&nbsp;test system.</p>