<p>In clinical studies, most adverse events were usually transient and not commonly of a severity requiring discontinuation of treatment. The most frequently reported adverse events were:</p>

<ul>
	<li><strong>Ocular</strong>: ocular hyperemia, dryness, tearing, burning and stinging, blurring and foreign body sensation, upper respiratory symptoms.</li>
	<li><strong>Systemic</strong>: oral dryness, headache, fatigue, drowsiness.</li>
</ul>