<p><strong>Metastatic ovarian cancer:</strong>&nbsp;As monotherapy: 100 mg/m2&nbsp;per cycle, given as a single dose infused in 0.9% sodium chloride or glucose once every 4 wk. For combination therapy with cyclophosphamide: 75-100 mg/m2&nbsp;on day 1 of every 4-wk cycle.<br />
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<strong>Metastatic testicular tumours:</strong>&nbsp;20 mg/m2&nbsp;BSA daily for 5 days per cycle.<br />
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<strong>Advanced bladder cancer:</strong>&nbsp;50-70 mg/m2&nbsp;per cycle once every 3-4 wk, depending on the extent of prior exposure to radiation and/or chemotherapy treatment. An initial dose of 50 mg/m2&nbsp;every 4 wk may be used in heavily pre-treated patients.<br />
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<strong>Usual dosage and schedule:</strong>&nbsp;40 to 120 mg/m2&nbsp;I.V. on day 1 as infusion every 3 weeks. 15 to 20 mg/m2&nbsp;I.V. on days 1 to 5 as infusion every 3 to 4 weeks. The usual dose in adults and children when used as single agent therapy is 50-100 mg/m2.</p>