<ul>
	<li><strong>Aminoglutethimide</strong>&nbsp;may lead to a loss of corticosteroid-induced adrenal suppression.</li>
	<li><strong>Amphotericin B injection and potassium-depleting agents</strong>- When corticosteroids are administered concomitantly with potassium-depleting agents (i.e., amphotericin B, diuretics), patients should be observed closely for the development of hypokalemia.</li>
	<li><strong>Macrolide antibiotics</strong>&nbsp;have been reported to cause a significant decrease in corticosteroid clearance.</li>
	<li><strong>Anticholinesterases</strong>- Concomitant use of anticholinesterase agents and corticosteroids may produce severe weakness in patients with myasthenia gravis. If possible, anticholinesterase agents should be withdrawn at least 24 hours before initiating corticosteroid therapy.</li>
	<li><strong>Anticoagulants, oral</strong>- Coadministration of corticosteroids and warfarin usually results in inhibition of response to warfarin, although there have been some conflicting reports.</li>
	<li><strong>Antidiabetics</strong>- Because corticosteroids may increase blood glucose concentrations, dosage adjustments of antidiabetic agents may be required.</li>
	<li><strong>Antitubercular drugs</strong>- Serum concentrations of isoniazid may be decreased.</li>
	<li><strong>Cholestyramine</strong>&nbsp;may increase the clearance of corticosteroids.</li>
	<li><strong>Cyclosporine</strong>&nbsp;Increased activity of both cyclosporine and corticosteroids may occur when the two are used concurrently. Convulsions have been reported with this concurrent use.</li>
	<li><strong>Digitalis glycosides</strong>- Patients on digitalis glycosides may be at increased risk of arrhythmias due to hypokalemia.</li>
	<li><strong>Estrogens, including oral contraceptive</strong>s- Estrogens may decrease the hepatic metabolism of certain corticosteroids, thereby increasing their effect.</li>
	<li><strong>Hepatic Enzyme Inhibitors</strong>- Drugs which inhibit cytochrome P450 3A4 have the potential to result in increased plasma concentrations of corticosteroids.</li>
	<li><strong>Ketoconazole</strong>&nbsp;has been reported to significantly decrease the metabolism of certain corticosteroids by up to 60%, leading to an increased risk of corticosteroid side effects.</li>
	<li><strong>Nonsteroidal anti-inflammatory agents (NSAIDs)</strong>- Concomitant use of aspirin and corticosteroids increases the risk of gastrointestinal side effects.</li>
	<li><strong>Skin tests</strong>- Corticosteroids may suppress reactions to skin tests.</li>
	<li><strong>Vaccines</strong>- Patients on prolonged corticosteroid therapy may exhibit a diminished response to toxoids and live or inactivated vaccines due to inhibition of antibody response.</li>
</ul>