<p><strong>Dosage in hepatic impairment</strong>: No dose adjustment is needed in patients with mild hepatic impairment. Bosentan is contraindicated in patients with moderate to severe liver dysfunction.<br />
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<strong>Dosage in renal impairment</strong>: No dose adjustment is required in patients with renal impairment. No dose adjustment is required in patients undergoing dialysis.<br />
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<strong>Dosage in elderly patients</strong>: No dose adjustment is required in patients over the age of 65 years.</p>