<p>The adult dose of Mannitol ranges from 50 to 100 gm by IV infusion. The rate of administration is usually adjusted to maintain a urine flow of at least 30 to 50 ml/hr. Total dosage, concentration and the rate of administration depends on fluid requirement, urinary output and the severity of the condition being treated<br />
<br />
Renal insufficiency-</p>

<ul>
	<li><strong>Adults</strong>: 50 to 100 g of Mannitol administered at a rate adjusted to maintain a urine flow of at least 30 to 50 ml/hr.</li>
	<li><strong>Children</strong>: 2 gm/kg or 60 gm/m2&nbsp;of body surface area administered over a period of 2 to 6 hrs.</li>
</ul>

<p>Cerebral edema, elevated intracranial pressure, elevated intraocular pressure, Glaucoma-</p>

<ul>
	<li><strong>Adults</strong>: 1.5 to 2 gm/kg&nbsp;administered over a period of 30 to 60 minutes.</li>
	<li><strong>Children</strong>: 1 to 2 gm/kg body wt. or 30 to 60 gm/m2&nbsp;of body surface area administered over a period of 30 to 60 mins.</li>
</ul>

<p>Adjunctive therapy for removal of toxic substances-</p>

<ul>
	<li><strong>Adults</strong>: 50 to 200 g of Mannitol administered at a rate adjust to maintain a urine flow of at least 100 to 500 ml/hr.</li>
	<li><strong>Children</strong>: 2 gm/kg or 60 gm/m2&nbsp;of body surface area</li>
</ul>

<p>For termination of pregnancy 50 gm of Mannitol (250 ml of Mannitol) is instilled into the amniotic cavity which induces abortion in a high proportion of pregnancies.</p>