<p><strong>Increased Heart Rate, Blood Pressure, And Ventricular Ectopic Activity</strong>: A 10- to 20-mm increase in&nbsp;systolic&nbsp;blood pressure and an increase in heart rate of 5 to 15 beats/minute have been noted in most patients (see&nbsp;WARNINGS&nbsp;regarding exaggerated chronotropic and pressor effects). Approximately 5% of patients have had increased premature&nbsp;ventricular&nbsp;beats during infusions. These effects are dose related.<br />
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<strong>Hypotension</strong>: Precipitous decreases in blood pressure have occasionally been described in association with&nbsp;dobutamine&nbsp;therapy. Decreasing the dose or discontinuing the infusion typically results in rapid return of blood pressure to baseline values. In rare cases, however, intervention may be required and reversibility may not be immediate.<br />
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<strong>Reactions At Sites Of Intravenous Infusion</strong>: Phlebitis&nbsp;has occasionally been reported. Local inflammatory changes have been described following inadvertent infiltration. Isolated cases of cutaneous necrosis&nbsp;(destruction of skin tissue) have been reported.<br />
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<strong>Miscellaneous Uncommon Effects</strong>: The following adverse effects have been reported in 1% to 3% of patients: nausea, headache, anginal pain, nonspecific chest pain,&nbsp;palpitations, and shortness of breath. Isolated cases of&nbsp;thrombocytopenia&nbsp;have been reported.<br />
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Administration of dobutamine, like other catecholamines, can produce a mild reduction in serum&nbsp;potassium&nbsp;concentration, rarely to hypokalemic levels.<br />
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<strong>Longer-Term Safety</strong>: Infusions of up to 72 hours have revealed no adverse effects other than those seen with shorter infusions.</p>