<p>If the hemorrhoidal symptoms do not disappear within 15 days, patient should ask doctor for advice. Diosmin (up to 900 mg/day) has been administered to a small number of breast cancer patients who were experiencing lymphedema following surgical and nodal irradiation treatment with resultant reduction of arm edema but no effect on the cancer. Animal studies and more than 20 years of clinical use in Europe have not found any evidence of carcinogenicity or mutagenicity when the components of Diosmin &amp; Hesperidin are used as recommended. As a precaution, Diosmin &amp; Hesperidin is not recommended for patients with a history of cancer since no specific studies have been performed in this population.</p>