<p><strong>Hepatic impairment</strong>: A dose reduction- guided by individual tolerance- is necessary in patients with severely impaired liver function.<br />
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<strong>Renal impairment</strong>: In patients with impairment of renal function (creatinine clearance below 30 mL/min) a dose reduction by approx. 30% to 50% may be necessary guided by individual tolerance.<br />
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<strong>Other</strong>: Treatment must be started at low-dose levels in hypotensive patients or patients whose circulation is unstable as well as in patients, who would be at particular risk from a reduction in blood pressure (e.g. patients with severe coronary heart disease or relevant stenoses of blood vessels supplying the brain); in such cases, the dose must only be increased gradually.</p>