<p><strong>Irritable Bowel Syndrome with Constipation</strong>:&nbsp;The recommended dose is 8 mcg twice daily orally with food and water.<br />
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<strong>Dosage in patients with hepatic impairment</strong>: Dosage adjustment is not required for patients with moderately impaired hepatic function. For patients with severely impaired hepatic function, the recommended starting dose is 8 mcg once daily. If tolerated then dose can be increased to 8 mcg twice&nbsp;<br />
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<strong>Chronic Idiopathic Constipation and Opioid-induced Constipation</strong>:&nbsp;The recommended dose is 24 mcg twice daily orally with food and water.&nbsp;<br />
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<strong>Dosage in patients with hepatic impairment</strong>: For patients with moderately impaired hepatic function, the recommended starting dose is 16 mcg twice daily. For patients with severely impaired hepatic function, the recommended starting dose is 8 mcg twice daily.</p>