<p>For Use in Chronic Spasticity:</p>

<ul>
	<li><strong>Adults</strong>: The following gradual titration schedule is suggested. Some patients will not respond until higher daily dosage is achieved. Each dosage level should be maintained for seven days to determine the patient&#39;s response. If no further benefit is observed at the next higher dose, dosage should be decreased to the previous lower dose.</li>
	<li>Starting dose is 25 mg twice per day and it can be increased to 25-50 mg per day per week. Maximum accepted dosage is 400 mg per day.</li>
	<li><strong>Paediatric Patients</strong>: The following gradual titration schedule is suggested. Some patients will not respond until higher daily dosage is achieved. Each dosage level should be maintained for seven days to determine the patient&#39;s response. If no further benefit is observed at the next higher dose, dosage should be decreased to the previous lower dose.</li>
	<li>0.5 mg/kg once daily for seven days, then 0.5 mg/kg 3 times for 7 days, 1 mg/kg 3 times for 7 days, 2 mg/kg 3 times a day, Therapy with a dose 4 times daily may be necessary for some individuals.</li>
</ul>

<p>For Malignant Hyperthermia</p>

<ul>
	<li><strong>Preoperatively</strong>: Administer 4 to 8 mg/kg/day of oral Dantrolene in 3 or 4 divided doses for one or two days prior to surgery, with the last dose being given approximately 3 to 4 hours before scheduled surgery with a minimum of water.</li>
	<li><strong>Post Crisis Follow-up</strong>: Oral Dantrolene should also be administered following a malignant hyperthermia crisis, in doses of 4 to 8 mg/kg per day in four divided doses, for a one to three day period to prevent recurrence of the manifestations of malignant hyperthermia.</li>
</ul>

<p>&nbsp;</p>