<p><strong>Conditions that need supervision</strong>: &nbsp;If any of the following conditions are present, have occurred previously, and/or have been aggravated during pregnancy or previous hormone treatment, the patient should be closely supervised. It should be taken into account that these conditions may recur or be aggravated during treatment with It, in particular:</p>

<ul>
	<li>Leiomyoma (uterine fibroids) or endometriosis</li>
	<li>Risk factors for, thromboembolic disorders &raquo; Risk factors for oestrogen dependent tumours, e.g. 1st degree heredity for breast cancer</li>
	<li>Hypertension</li>
	<li>Liver disorders (e.g. liver adenoma)</li>
	<li>Diabetes mellitus with or without vascular involvement</li>
	<li>Cholelithiasis</li>
	<li>Migraine or (severe) headache</li>
	<li>Systemic lupus erythematosus</li>
	<li>A history of endometrial hyperplasia</li>
	<li>Epilepsy</li>
	<li>Asthma</li>
	<li>Otosclerosis</li>
	<li>Hereditary angioedema.</li>
</ul>

<p><strong>If you forget to take Estradiol Valerate</strong>: If the woman forgets to take a tablet at the usual time, she may take it within the following 12 hours. If the woman is more than 12 hours late the forgotten tablet should not be taken and the remaining tablets taken at the usual time on the right days. A missed dose may lead to breakthrough bleeding or spotting.</p>