<p><strong>Renal Impairment Patients</strong>: The usual regimens of therapy with this may be followed provided the patient&#39;s creatinine clearance is &gt;30 ml/min. In patients with more severe renal impairment, loop diuretics are preferred to thiazides. So, this preparation is not recommended.<br />
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<strong>Hepatic Impairment Patients</strong>: No dosage adjustment is necessary with hepatic impairment.<br />
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<strong>Paediatric use</strong>: Safety and effectiveness in paediatric patients have not been established.<br />
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<strong>Geriatric use</strong>: Clinical studies of Olmesartan and Hydrochlorothiazide combination did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. In general, dose selection for an elderly patient should be cautious.</p>