<p>Azathioprine is indicated as an adjunct for the prevention of rejection in renal homotransplantation. It is also indicated for the management of active&nbsp;rheumatoid arthritis&nbsp;to reduce signs and symptoms.<br />
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<strong>Renal Homotransplantation</strong>: Azathioprine is indicated as an adjunct for the prevention of rejection in renal homotransplantation. Experience with over 16,000 transplants shows a 5-year patient survival of 35% to 55%, but this is dependent on&nbsp;donor, match for&nbsp;HLA&nbsp;antigens, anti-donor or anti-B-cell alloantigen antibody, and other variables. The effect of Azathioprine on these variables has not been tested in controlled trials.<br />
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<strong>Rheumatoid Arthritis</strong>: Azathioprine is indicated for the treatment of active rheumatoid arthritis (RA) to reduce signs and symptoms.&nbsp;Aspirin, non-steroidal anti-inflammatory drugs and/or low dose glucocorticoids may be continued during treatment with Azathioprine. The combined use of Azathioprine with disease modifying anti-rheumatic drugs (DMARDs) has not been studied for either added benefit or unexpected adverse effects. The use of Azathioprine with these agents cannot be recommended.</p>