<p>Experience with doses higher than the recommended therapeutic dose is limited. In the event of overdose the patient should be observed and an appropriate symptomatic treatment given. Generally, the reported outcome in these cases was &quot;improved&quot; or &quot;recovered&quot;. Events that have been reported at different dose ranges are as follows:<br />
<br />
<strong>Adult Population</strong>:</p>

<ul>
	<li>1200 to 1600 mg (duration varying between 1 to 10 days): Nausea, vomiting, diarrhoea, rash, erythema, oedema, swelling, fatigue, muscle spasms, thrombocytopenia, pancytopenia, abdominal pain, headache, decreased appetite.</li>
	<li>1800 to 3200 mg (as high as 3200 mg daily for 6 days): Weakness, myalgia, increased creatine phosphokinase,</li>
	<li>increased bilirubin, gastrointestinal pain.</li>
	<li>6400 mg (single dose): One case reported in the literature of one patient who experienced nausea, vomiting, abdominal pain, pyrexia, facial swelling, decreased neutrophil count, and increased transaminases.</li>
	<li>8 to 10 g (single dose): Vomiting and gastrointestinal pain have been reported.</li>
</ul>

<p><strong>Paediatric population</strong>: One 3-year-old male exposed to a single dose of 400 mg experienced vomiting, diarrhoea and anorexia and another 3-year-old male exposed to a single dose of 980 mg experienced decreased white blood cell count and diarrhoea. In the event of overdose, the patient should be observed and appropriate supportive treatment given.</p>