<p><strong>Adults</strong>: The recommended dose is Ciprofbrate 100 mg per day. This dose should not be exceeded.<br />
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<strong>Patients with renal insufficiency</strong>: In moderate renal impairment (creatinine clearance 30-80 ml/min/1.73 m2) it is recommended that dosage be reduced to one tablet every other day. Patients should be carefully monitored. Ciprofbrate should not be used in severe renal impairment (creatinine clearance &lt;30 ml/min/1.73 m2).<br />
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<strong>Patients with hepatic insufficiency</strong>: Use with caution in patients with impaired hepatic function. Ciprofbrate treatment should be discontinued in case of increased AST and ALT levels to more than 3 times the upper limit of normal or if cholestatic liver injury is evidenced.<br />
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<strong>Elderly</strong>: As for adults but precautions should be taken for Age more than 70 years.<br />
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<strong>Paediatric population</strong>: Not recommended since safety and efficacy in children has not been established.</p>