<p>Therapy should be initiated with the lowest possible dose and then titrated according to individual patient response. A single dose given in the morning with food is recommended; divided doses are unnecessary.<br />
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<strong>Edema</strong>: Up to 50 mg daily.<br />
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<strong>Hypertension</strong>: 25 mg daily in the morning, increased to 50 mg daily if necessary.<br />
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<strong>Heart failure</strong>: 25-50 mg daily in the morning, increased if necessary to 100-200 mg daily (reduce to lowest effective dose for maintenance).<br />
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Maintenance doses may often be lower than initial doses and should be adjusted according to the individual patient.</p>