<p>Ranolazine has anti-ischemlc and antlanginal effects that do not depend upon reductions in heart rate or blood pressure.The exact mechanism of action of ranolazine is unknown. Ranolazine at therapeutic levels can inhibit the cardiac late sodium current (INa). However, the relationship of this inhibition to angina symptoms is uncertain.<br />
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The QT prolongation effect of ranolazine on the surface electrocardiogram is the result of inhibition of IKr&nbsp;which prolongs the ventricular action potential.</p>