<p>Intravenous-<br />
Prophylaxis against urothelial toxicity:</p>

<ul>
	<li><strong>Adult:</strong>&nbsp;Refer to individual and local protocol. Dose calculated according to cytotoxic dose. Normally given at a dose &ge;cytotoxic dose. Duration of treatment should be as long as cytotoxic treatment; plus the time it takes for concentration of antineoplastic metabolites in urine to fall. Administered either by short (15-30 minutes) or continuous (24 hr) infusion.</li>
	<li><strong>Child:</strong>&nbsp;Refer to individual and local protocol. Has been used in children &gt;4 mth.</li>
</ul>

<p>Oral-<br />
Prophylaxis against urothelial toxicity:</p>

<ul>
	<li><strong>Adult</strong>: Refer to individual and local protocol. Dose calculated according to cytotoxic dose. Normally given at a dose &ge;cytotoxic dose. Duration of treatment should be as long as cytotoxic treatment; plus the time it takes for concentration of antineoplastic metabolites in urine to fall.</li>
	<li><strong>Child</strong>: Refer to individual and local protocol.</li>
</ul>