<p>With medicine:</p>

<ul>
	<li>Concomitant use of NSAIDs may reduce the antihypertensive effect of ACE inhibitors, diuretics &amp; beta-blockers</li>
	<li>Concomitant use of this tablet and warfarin may result in an increased risk of a bleeding complication.</li>
	<li>Esomeprazole inhibits gastric acid secretion &amp; may interfere with the absorption of drugs where gastric pH is an important determinant of bioavailability (eg. Ketoconazole, iron salts and digoxin).</li>
</ul>

<p>With food &amp; others: Administration of Naproxen &amp; Esomeprazole together with high-fat food in healthy volunteers does not affect the extent of absorption of naproxen but significantly prolongs tmax&nbsp;by 10 hours and decreases peak plasma concentration (Cmax) by about 12%</p>