<p><strong>Deep vein thrombosis</strong>: Initial loading dose of 4,400 IU/kg in 15 mL soln over 10 min, followed by 4,400 IU/kg/hr IV infusion for 12-24 hr.&nbsp;<br />
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<strong>Pulmonary embolism</strong>: Initial loading dose of 4,400 IU/kg in 15 mL soln over 10 min followed by 4,400 IU/kg/hr IV infusion for 12 hr.&nbsp;<br />
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<strong>Peripheral vascular occlusion</strong>: Infuse 2,500 IU/mL (500,000 IU in 200 mL) into clot at a rate of 4,000 IU/min for 2 hr.<br />
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Advance the catheter into the remaining occluded area &amp; infuse at 4,000 IU/min for another 2 hr. This may be repeated up to 4 times.&nbsp;<br />
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<strong>Hyphaema</strong>: 5,000 IU in 2 mL saline soln is injected and withdrawn repeatedly over the iris. If residual clot remains, leave 0.3 mL in the anterior chamber for 24-48 hr to facilitate further dissolution.&nbsp;<br />
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<strong>Clotted arterio-venous shunts</strong>: Instill 5,000-25,000 IU into affected shunt limb &amp; clamp for 2-4 hr, followed by aspiration of lysate. Repeat if necessary.</p>