<p><strong>Adult with normal hepatic function</strong>: Pefloxcin 400 mg tablet 12 hourly (morning &amp; evening) with meals to avoid gastrointestinal disturbances. An initial loading dose of 800 mg may be given in order to produce effective blood concentration more rapidly.<br />
<br />
<strong>Adult with hepatic insufficiency</strong>: In patients with severe hepatic insufficiency or reduced blood supply to the liver, the daily doses should be readjusted by increasing the intervals between doses. Dosage need not to be reduced in renal insufficiency.<br />
<br />
Duration of Treatment:</p>

<ul>
	<li>Usually 5 to 10 days.</li>
	<li>For chronic prostatitis, cystic fibrosis &amp; chronic Salmonella carriers: 14 days.</li>
	<li>For endocarditis: Up to 6 months.</li>
	<li>For chronic osteomyelitis: Up to 1 year.</li>
	<li>For gonorrhoea: 2 tablets single dose.</li>
</ul>