<p>The dose should be adjusted in case of patients with renal impairment<br />
<br />
<strong>Adult</strong>:</p>

<ul>
	<li>Mild impairment (Creatinine clearance&gt; 30ml/minute): No changein dosage.</li>
	<li>Moderate impairment (Creatinine clearance 10-30 ml/minute): One 375 Tablet or one 625 Tablet 12 hourly or 1.2 gm IV followed by 0.6 gm IV 12 hourly.</li>
	<li>Severe impairment (Creatinine clearance &lt;10 ml/minute): Not more than one 375 mg tablet 12 hourly or 1.2 gm IV followed by 0.6 gm IV 24 hourly. Dialysis decreases serum concentrations of this preparation and an additional 0.6 gm IV dose may need to be given during dialysis and at the end of dialysis.</li>
</ul>

<p><strong>Children</strong>:</p>

<ul>
	<li>A similar reduction in dosage should be made for children.</li>
	<li>Administration hepatic impairment: Dose with caution; monitor hepatic function at regular intervals.</li>
</ul>