<p><strong>Pediatric Use</strong>: Safety and effectiveness of Sofosbuvir in children less than 18 years of age have not been established.<br />
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<strong>Geriatric Use</strong>: Sofosbuvir was administered to 90 subjects aged 65 and over. The response rates observed for subjects over 65 years of age were similar to that of younger subjects across treatment groups. No dose adjustment of Sofosbuvir is warranted in geriatric patients.</p>