<p><strong>Acute Ischemic Stroke</strong>: Do not administer Alteplase to treat acute ischemic stroke in the following situations in which the risk of bleeding is greater than the potential benefit [see Warnings and Precautions (5.1)]:</p>

<ul>
	<li>Current intracranial hemorrhage</li>
	<li>Subarachnoid hemorrhage</li>
	<li>Active internal bleeding</li>
	<li>Recent (within 3 months) intracranial or intraspinal surgery or serious head trauma</li>
	<li>Presence of intracranial conditions that may increase the risk of bleeding (e.g., some neoplasms, arteriovenous malformations, or aneurysms)</li>
	<li>Bleeding diathesis</li>
	<li>Current severe uncontrolled hypertension.</li>
</ul>

<p><strong>Acute Myocardial Infarction or Pulmonary Embolism</strong>: Do not administer Alteplase for treatment of AMI or PE in the following situations in which the risk of bleeding is greater than the potential benefit:</p>

<ul>
	<li>Active internal bleeding</li>
	<li>History of recent stroke</li>
	<li>Recent (within 3 months) intracranial or intraspinal surgery or serious head trauma</li>
	<li>Presence of intracranial conditions that may increase the risk of bleeding (e.g. some neoplasms, arteriovenous malformations, or aneurysms)</li>
	<li>Bleeding diathesis</li>
	<li>Current severe uncontrolled hypertension.</li>
</ul>