<p><strong>Adult</strong>: The usual dose is 1 to 2 gm by intravenous or intramuscular administration once a day (or in equally divided doses twice a day).</p>

<ul>
	<li><strong>Pneumonia, Bronchitis, Acute bacterial otitis media, Skin and skin structure infection, Urinary tract infections, Bacterial Septicemia, Bone and joint infections, Meningitis</strong>: 1 to 2 g IV or IM once a day (or in equally divided doses twice a day); Maximum dose: 4 gm/day</li>
	<li><strong>Uncomplicated gonococcal infections</strong>: 250 mg IM as a single dose</li>
	<li><strong>Surgical prophylaxis</strong>: 1 g IV as a single dose 30 to 120 minutes before surgery</li>
</ul>

<p><strong>Infants and Children (01 month or older)</strong>: The usual dose is 50 to 75 mg/kg intravenous or intramuscular administration once a day (or in equally divided doses twice a day).</p>

<ul>
	<li><strong>Pneumonia, Bronchitis, Skin and skin structure infection, Urinary tract infections, Bacterial Septicemia, Bone and joint infections</strong>: 50 to 75 mg/kg IV or IM once a day (or in equally divided doses twice a day); Maximum dose: 2 gm/day</li>
	<li><strong>Acute bacterial otitis media</strong>: 50 mg/kg IM in single dose; Maximum dose: 1 gm/day</li>
	<li><strong>Meningitis</strong>: 100 mg/kg IV or IM in single daily dose or (or in equally divided doses twice a day); Maximum dose: 4 gm/day</li>
</ul>

<p><strong>Duration of therapy</strong>: Continue for more than 2 days after signs and symptoms of infection have disappeared. Usual duration is 4 to 14 days; in complicated infections, longer therapy may be required.</p>

<p>&nbsp;</p>

<p><strong>Administration</strong></p>

<p>Preparation of Solutions for Intramuscular / Intravenous Injections:</p>

<ul>
	<li><strong>For Intramuscular Injection</strong>: 250 mg or 500 mg Ceftriaxone should be dissolved in 2 ml Lidocaine HCI 1% injection or 1 g Ceftriaxone in 3.5 ml of Lidocaine HCI 1% injection.</li>
	<li><strong>For Intravenous Injection</strong>: 250 mg or 500 mg Ceftriaxone should be dissolved in 5 ml of Water for injection or 1 g Ceftriaxone in 10 ml of Water for injection USP or 2 g Ceftriaxone in 20 ml of Water for injection.</li>
</ul>

<p>The injection should be administered over 2-4 minutes, by Intramuscular or Intravenous injection or by tubing infusion over a period of 30 minutes at concentration between 10 mg/mL and 40 mg/mL. Before starting treatment through Ceftriaxone injection, patient tolerance test should be checked by administration of a test dose. (The use of freshly reconstituted solution is recommended. However, it maintains potency for at least 6 hours at room temperature or 24 hours at 5&deg;C).</p>