<p>Rizatriptan binds with high&nbsp;affinity&nbsp;to human cloned 5-HT1B/1D receptors. Rizatriptan Benzoate presumably exerts its therapeutic effects in the treatment of&nbsp;migraine headache&nbsp;by binding to 5-HT1B/1D receptors located on intracranial blood vessels and sensory nerves of the trigeminal system.</p>