<p><strong>Intravenous (Adult)</strong>-<br />
<br />
<strong>Treatment and prophylaxis of haemorrhagic episodes in patients with haemophilia A</strong>:&nbsp;Dosage is individualised based on coagulation tests performed before treatment and at regular intervals during treatment. Generally, 1 IU/kg will increase circulating factor VIII levels by about 2 IU/dL. Recommended doses vary according to the preparation used.<br />
<br />
<strong>Suggested doses</strong>: Mild-moderate haemorrhage (increase to 20-30% of normal): Usually with a single dose of 10-15 IU/kg;<br />
<br />
<strong>More serious haemorrhage or minor surgery (increase to 30-50% of normal)</strong>: Usual initial dose of 15-25 units/kg followed by 10-15 IU/kg every 8-12 hr if required;<br />
<br />
<strong>Severe haemorrhage or major surgery (increase to 80-100% of normal)</strong>: Usual initial dose of 40-50 IU/kg followed by 20-25 IU/kg every 8-12 hr. Refer to individual product information for further dosing details.<br />
<br />
<strong>Prophylaxis in severe haemophilia A</strong>:&nbsp;10-50 IU/kg every 2-3 days, as needed.</p>