<p><strong>Pediatric Use</strong>: The safety and effectiveness of Paracetamol IV for the treatment of acute pain and fever in pediatric patients ages 2 years and older is supported by evidence from adequate and well-controlled studies of Paracetamol IV in adults.<br />
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<strong>Geriatric use</strong>: No overall differences in safety or effectiveness were observed between these subjects and younger subjects, and other reported clinical experience has not identified differences in responses between the elderly and younger patients.<br />
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<strong>Patients with Hepatic Impairment</strong>: Paracetamol is contraindicated in patients with severe hepatic impairment or severe active liver disease and should be used with caution in patients with hepatic impairment or active liver disease. A reduced total daily dose of Paracetamol may be warranted.<br />
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<strong>Patients with Renal Impairment</strong>: In cases of severe renal impairment (creatinine clearance &lt; 30 ml/min), longer dosing intervals and a reduced total daily dose of Paracetamol may be warranted.</p>