<p><strong>CNS Effects</strong>: Drowsiness is the most prominent CNS effect of the drug. Extrapyramidal reactions may occur with high doses; this is almost always responsive to a reduction in dosage. Other reported reactions include dizziness, lassitude, tinnitus, incoordination, fatigue, blurred vision, euphoria, diplopia, nervousness, insomnia, tremors, convulsive seizures, oculogyric crises, excitation, catatonic-like states, hysteria, and hallucinations.<br />
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<strong>Cardiovascular Effects</strong>: Tachycardia, bradycardia, faintness, dizziness, and increases and decreases in blood pressure have been reported following the use of Promethazine hydrochloride injection. Venous thrombosis at the injection site has been reported.<br />
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<strong>Gastrointestinal Effects</strong>: Nausea and vomiting have been reported, usually in association with surgical procedures and combination drug therapy.<br />
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<strong>Allergic Reactions</strong>: These include urticaria, dermatitis, asthma, and photosensitivity. Angioneurotic edema has been reported.<br />
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<strong>Other Reported Reactions</strong>: Leukopenia and agranulocytosis, usually when promethazine has been used in association with other known marrow-toxic agents, have been reported. Thrombocytopenic purpura and jaundice of the obstructive type have been associated with the use of promethazine. The jaundice is usually reversible on discontinuation of the drug. Subcutaneous injection has resulted in tissue necrosis. Nasal stuffiness may occur. Dry mouth has been reported.</p>