<p><strong>Hepatic Dysfunction:</strong>&nbsp;Propafenone is highly metabolized by&nbsp;the liver and should therefore, be&nbsp;administered cautiously to patients with impaired hepatic function. As a result,&nbsp;the dose of propafenone given to patients with impaired hepatic function&nbsp;should be approximately 20 to 30% of&nbsp;the dose given to patients with normal&nbsp;hepatic function.<br />
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<strong>Renal Dysfunction:</strong>&nbsp;A considerable percentage of propafenone metabolites (18.5% to 38% of the&nbsp;dose/48 hours) are excreted in the urine. Until further data are available, propafenone should be administered&nbsp;cautiously to patients with impaired&nbsp;renal function.<br />
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<strong>Neuromuscular Dysfunction:</strong>&nbsp;Exacerbation of myasthenia gravis has been reported during propafenone&nbsp;therapy.</p>