<p>Correct preexisting hypocalcaemia prior to therapy. Osteonecrosis of the jaw (ONJ). Perform oral &amp; dental exam with preventive dentistry prior to treatment. Avoid invasive dental procedures &amp; maintain good oral hygiene while on treatment. Atypical femoral fractures. Severe renal impairment (CrCl &lt;30 ml/min) or in patients receiving dialysis. Concomitant use with other denosumab-containing prep. Pregnancy &amp; lactation. Children.</p>