<p>Linagliptin 5 mg once daily. If added to metformin, the dose of metformin should be maintained and linagliptin administered concomitantly. When used in combination with a sulfonylurea, a lower dose of the sulphonylurea may be considered to reduce the risk of hypoglycaemia.<br />
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Patients with renal impairment: No dose adjustment required. Linagliptin can be taken with or without a meal at any time of the day.</p>