<p><strong>CYP 3A Inhibitors</strong>: Do not use Ranolazine with strong CYP 3A inhibitors. With moderate CYP 3A inhibitors (e.g., diltiazem, verapamil, erythromycin) limit maximum dose of ranolazine to 500 mg twice daily.<br />
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<strong>CYP 3A Inducers</strong>: Do not use Ranolazine with inducers.<br />
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<strong>P-gp Inhibitors (e.g., Cyclosporin)</strong>: May need to lower the Ranolazine dose based on clinical dose.<br />
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<strong>Drugs transported by P-gp or metabolized by CYP2D6 (eg., digoxin, TCA)</strong>: May need reduced doses of these drugs when used with ranolazine.</p>