<p><strong>Digoxin</strong>: Concomitant administration of Simvastatin and Digoxin in normal volunteers resulted in a slight elevation (less than 0.3 &micro;gm/ml) in drug concentrations in plasma compared to concomitant administration of placebo and Digoxin.<br />
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<strong>Coumarin derivatives</strong>: Slightly enhance the anticoagulant effect of Warfarin (mean changes in p rothrombin time less than two seconds) in normal volunteers maintained in a state of low therapeutic anticoagulation.<br />
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<strong>Others</strong>: In clinical studies, Simvastatin was used concomitantly with ACE inhibitors, beta-blockers, calcium channel blockers, diuretics and NSAIDs without evidence of clinically significant adverse interactions.</p>