<p>The maximum established exposure has not exceeded 60 mg twice daily, or 160 mg once daily. Effects are&nbsp; generally minimal, representative of the known adverse event profile and reversible without further medical intervention. No specific antidote is known. Rabeprazole&nbsp;is extensively protein bound and is, therefore, not dialysable. As in any case of overdose, treatment should be symptomatic and general supportive measures should be utilised.</p>