<p>Tablets are to be taken orally morning and evening, with or without food.<br />
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<strong>Pulmonary arterial hypertension</strong>: ln adult patients, Bosentan treatment should be initiated at a dose of 62.5 mg twice daily for 4 weeks and then increased to the maintenance dose of 125 mg twice daily.<br />
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For paediatric patients aged 2 years or older, the optimal maintenance dose has not been defined in well-controlled studies. However, paediatric pharmacokinetic data have shown that Bosentan plasma concentrations in children were on average lower than in adult patients and were not increased by increasing the dose of Bosentan above 2 mg/kg body weight twice daily.<br />
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<strong>Discontinuation of treatment</strong>: lf the decision to withdraw Bosentan is taken, it should be done gradually while an alternative therapy is introduced.</p>