<p><strong>Active Duodenal Ulcer and Active Benign Gastric Ulcer</strong>: The recommended oral dose for both bioactive duodenal ulcer and active benign gastric ulcer is 20 mg to be taken once daily in the morning. Most patients with active duodenal ulcer heal within four weeks. However, a few patients may require an additional four weeks of therapy to achieve healing. Most patients with active benign gastric ulcer heal within six weeks. However, again a few patients may require an additional six weeks of therapy to achieve healing.<br />
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<strong>Erosive or Ulcerative Gastro-Esophageal Reflux Disease (GERD)</strong>: The recommended oral dose for this condition is 20 mg to be taken once daily for four to eight weeks.<br />
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<strong>Gastro-Esophageal Reflux Disease Long-term Management (GERD Maintenance)</strong>: For long-term management, a maintenance dose of rabeprazole sodium 20 mg or 10 mg once daily can be used depending upon patient response.<br />
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<strong>Symptomatic treatment of moderate to very severe Gastro-Esophageal Reflux Disease (symptomatic GERD)</strong>: 10 mg once daily in patients without oesophagitis. If symptom control has not been achieved during four weeks, the patient should be further investigated. Once symptoms have resolved, subsequent symptom control can be achieved using an on-demand regimen taking 10 mg once daily when needed.<br />
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<strong>Zollinger-Ellison Syndrome</strong>: The recommended adult starting dose is 60 mg once a day. The dose may be titrated upwards to 120 mg/day based on individual patient needs. Single daily doses up to 100 mg/day may be given. 120 mg dose may require divided doses, 60 mg twice daily. Treatment should continue for as long as clinically indicated.<br />
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<strong>Eradication of H. pylori</strong>: Patients with H. pylori infection should be treated with eradication therapy. The following combination given for 7 days is recommended. Rabeprazole sodium 20 mg twice daily, clarithromycin 500 mg twice daily and amoxicillin 1g twice daily.</p>

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<p><strong>Administration</strong></p>

<p>For indications requiring once-daily treatment Rabeprazole tablets should be taken in the morning, before eating; and although neither the time of day nor food intake was shown to have any effect on rabeprazole sodium activity, this regimen will facilitate treatment compliance. Patients should be cautioned that the Rabeprazole tablets should not be chewed or crushed, but should be swallowed whole.</p>