<p>Not to be used with potent inhibitors of CYP3A4 and protease inhibitors. Hyperthyroidism, renal or hepatic impairment. Pre existing vascular disease including coronary disease, obliterative vascular disease, angina, claudication, peripheral ischaemia, Raynaud&#39;s syndrome and hypertension. Not to be used when there is sepsis. Pregnancy and lactation</p>