<p>Intrathecal (Adult)-</p>

<ul>
	<li><strong>Leukaemic meningitis</strong>:&nbsp;5-75 mg/m2&nbsp;or 30-100 mg once every 2-7 days to once daily for 4 or 5 days.</li>
	<li>For lymphomatous meningitis: 50 mg every 2 wk for 5 doses, then every 4 wk for 5 doses.</li>
</ul>

<p>Parenteral (Adult)-<br />
Induction and maintenance of remission in acute leukaemias:&nbsp;</p>

<ul>
	<li><strong>As monotherapy</strong>: 200 mg/m2&nbsp;daily by continuous IV infusion for 5 days, at intervals of approx 2 wk.</li>
	<li><strong>In combination therapy</strong>: 100 mg/m2&nbsp;bid by rapid IV inj or 100 mg/m2&nbsp;daily by continuous IV infusion both for 7 days. Maintenance: 1-1.5 mg/kg once or twice wkly via IV or SC.</li>
</ul>