<p><strong>Aspirin:</strong>&nbsp;Concomitant administration with aspirin is not recommended because Diclofenac Sodium is displaced from its binding sites by aspirin, resulting in lower plasma concentrations, peak plasma levels and AUC values.<br />
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<strong>Digoxin:</strong>&nbsp;Elevated digoxin levels have been reported in patients receiving digoxin and Diclofenac Sodium. Antihypertensives: NSAIDs can inhibit the activity of antihypertensives, including ACE inhibitors.<br />
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<strong>Warfarin</strong>: The effects of warfarin and NSAIDs on GI bleeding are synergistic, such that users of both drugs together have a risk of serious bleeding greater than users of either drug alone.<br />
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<strong>Oral hypoglycaemics:</strong>&nbsp;Diclofenac Sodium does not alter glucose metabolism in healthy people nor it alters the effects of oral hypoglycaemics. Diclofenac Sodium may alter diabetic patient&rsquo;s response to insulin or oral hypoglycaemics.<br />
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<strong>Antacids:</strong>&nbsp;Antacids reduce the bioavailability of Misoprostol. Antacids may also delay absorption of Diclofenac Sodium.<br />
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<strong>Diuretics:</strong>&nbsp;The Diclofenac Sodium component like other NSAIDs, can inhibit the activity of diuretics. Concomitant therapy with potassium-sparing diuretics may be associated with increased serum potassium levels.</p>