<p>Combination of Rosiglitazone and Metformin tablets are<br />
contraindicated in patients with:</p>

<ul>
	<li>Renal disease or renal dysfunction which may also result from conditions such as cardiovascular collapse (shock), acute myocardial infarction, and septicemia</li>
	<li>Congestive heart failure requiring pharmacologic treatment.</li>
	<li>Known hypersensitivity to Rosiglitazone maleate or Metformin hydrochloride.</li>
	<li>Acute or chronic metabolic acidosis, including diabetic ketoacidosis, with or without coma. Diabetic ketoacidosis should be treated with insulin.</li>
</ul>

<p>Combination of Rosiglitazone and Metformin should be temporarily discontinued in patients undergoing radiologic studies involving intravascular administration of iodinated contrast materials, because use of such products may result in acute alteration of renal function.</p>