<p><strong>Mineralocorticoid excess</strong>: Closely monitor patients with cardiovascular disease. Control hypertension and correct hypokalemia before treatment. Monitor blood pressure, serum potassium and symptoms of fluid retention at least monthly.<br />
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<strong>Adrenocortical insufficiency</strong>: Monitor for symptoms and signs of adrenocortical insufficiency. Increased dosage of corticosteroids may be indicated before, during and after stressful situations.<br />
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<strong>Hepatotoxicity</strong>: Can be severe and fatal. Monitor liver function and modify, interrupt, or discontinue Abiraterone dosing as recommended.<br />
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<strong>Increased fractures and mortality in combination with radium Ra 223 dichloride</strong>: Use of Abiraterone plus prednisone/prednisolone in combination with radium Ra 223 dichloride is not recommended.<br />
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<strong>Embryo-Fetal Toxicity</strong>: Abiraterone can cause fetal harm. Advise males with female partners of reproductive potential to use effective contraception.</p>