<p><strong>Olmesartan</strong>: No significant drug interactions were reported in studies in which Olmesartan Medoxomil was co-administered with hydrochlorothiazide, digoxin or warfarin in healthy volunteers. Olmesartan Medoxomil is not metabolized by the cytochrome P450 system and has no effects on P450 enzymes; thus, interactions with drugs that inhibit, induce or are metabolized by those enzymes are not expected.<br />
<br />
<strong>Hydrochlorothiazide</strong>: When administered concurrently, the following drugs may interact with Thiazide diuretics:</p>

<ul>
	<li>Alcohol, Barbiturates or Narcotics: Potentiation of orthostatic hypotension may occur.</li>
	<li>Antidiabetic drugs (oral agents and Insulin): Dosage adjustment of the antidiabetic drug may be required.</li>
	<li>Other antihypertensive drugs: Additive effect.</li>
	<li>Corticosteroids, ACTH.</li>
	<li>Lithium.</li>
</ul>