<p><strong>Use In Renal Dysfunction</strong>: Relatively oliguric patients, especially those with tubular&nbsp;necrosis&nbsp;in the immediate postcadaveric transplant period, may have delayed clearance of Azathioprine&nbsp;or its metabolites, may be particularly sensitive to this drug, and are usually given lower doses. Procedures for proper handling and disposal of this immunosuppressive antimetabolite&nbsp;drug should be considered. Several guidelines on this subject have been published.25-31&nbsp;There is no general agreement that all of the procedures recommended in the guidelines are necessary or appropriate.</p>