<p>Ketoprofen is contraindicated in patients who have a history of hypersensitivity reactions such as asthmatic attacks or other allergic-type reactions to ketoprofen, ASA or other NSAIDs. Severe, rarely fatal, anaphylactic reactions have been reported in such patients. Ketoprofen is also contraindicated in the following cases:</p>

<ul>
	<li>Severe heart failure</li>
	<li>Active or history of peptic ulcer/hemorrhage</li>
	<li>History of gastrointestinal bleeding or perforation, related to previous NSAIDs therapy</li>
	<li>Severe hepatic insufficiency</li>
	<li>Severe renal insufficiency</li>
	<li>Third trimester of pregnancy</li>
	<li>Rectitis or history of proctorrhagia (rectal administration)</li>
</ul>