<p><strong>Adult:</strong>&nbsp;400 mg bid. May continue until patient shows unacceptable toxicity or evidence of progression.<br />
<br />
<strong>Patient on strong CYP3A4 inhibitor:</strong>&nbsp;Reduce dose to 300 mg once daily, or to 200 mg once daily in newly-diagnosed chronic phase Philadelphia chronic myelogenous leukaemia. Dose may be adjusted to usual dose after a washout period.<br />
<br />
<strong>Patient on drugs that prolong QT interval</strong>&nbsp;(e.g. antiarrhythmics): Reduce dose and closely monitor for QT interval prolongation.<br />
<br />
<strong>Hepatic Impairment:</strong>&nbsp;Use a lower starting dose.</p>

<p>&nbsp;</p>

<p><strong>Administration</strong></p>

<p>Should be taken on an empty stomach. Avoid food at least 2 hr before &amp; at least 1 hr after a dose. Swallow whole, do not chew/crush. Avoid grapefruit products.</p>