<p><strong>Patients with renal impairment</strong>: No dosage adjustment is necessary for patients with mild or moderate renal impairment where creatinine clearance is &ge;30 ml/min. Below 30 ml/min creatinine clearance, the decision to administer Ibandronic Acid should be based on an individual risk-benefit assessment.<br />
<br />
<strong>Patients with hepatic impairment</strong>: No dosage adjustment is necessary.<br />
&nbsp;</p>

<p><strong>Elderly</strong>: No dosage adjustment is necessary.</p>

<p>&nbsp;</p>

<p><strong>Children</strong>: Safety and efficacy have not been established in patients less than 18 years old.</p>