<p>Contraindicated in patients with:</p>

<ul>
	<li>Renal disease or renal dysfunction (e.g. as suggested by serum creatinine levels &gt;1.5 mg/dl in male, &gt;1.4 mg/dl in females or abnormal creatinine clearance), which may also result from conditions such as cardiovascular collapse (shock), acute myocardial infarction and septicemia.</li>
	<li>Known hypersensitivity to Pioglitazone, Metformin or any other component of this combination.</li>
	<li>Acute or chronic metabolic acidosis including diabetic ketoacidosis with or without coma.</li>
</ul>