<p>The dosage is adjusted according to the response of the patient and site of administration.<br />
<br />
<strong>Adult</strong>: For healthy adults, the maximum individual dose should not exceed 4.5mg/kg of body weight and in general it is recommended that the maximum total dose does not exceed 300 mg. Recommended doses given in the below serve only as a guide to the amount of anaesthetic required for most routine procedures.<br />
<br />
Infiltration-</p>

<ul>
	<li>Percutaneous: Total dose 5-300 mg</li>
	<li>Intravenous regional: Total dose 50-300 mg</li>
</ul>

<p>Peripheral Nerve Blocks-</p>

<ul>
	<li>Brachial: Total dose 225-300 mg</li>
	<li>Dental: Total dose 20-100 mg</li>
	<li>Intercostal: Total dose 30 mg</li>
	<li>Paravertebral: Total dose 30-50 mg</li>
</ul>

<p>Pudenal (each side):&nbsp;</p>

<ul>
	<li>Paracervical Obstetrical analgesia: Total dose 100 mg</li>
</ul>

<p>Sympathetic Nerve Blocks</p>

<ul>
	<li>Cervical: Total dose 50 mg</li>
	<li>Lumbar: Total dose 50-100 mg</li>
</ul>

<p>Central Neural Blocks</p>

<ul>
	<li>Epidural: Total dose 200-300 mg [Dose determined by number of dermatomes to be anesthetized (2-3 mL/dermatome) periodically.]</li>
	<li>Thoracic: Total dose 200-300 mg</li>
</ul>

<p>Lumbar</p>

<ul>
	<li>Analgesia: Total dose 250-300 mg</li>
	<li>Anesthesia: Total dose 200-300 mg</li>
</ul>

<p>Caudal</p>

<ul>
	<li>Obstetrical analgesia: Total dose 200-300 mg</li>
	<li>Surgical anesthesia: Total dose 225-300 mg<strong>.</strong></li>
</ul>

<p>&nbsp;</p>

<p><strong>Administration</strong></p>

<p>Antiarrhythmic treatment: An intravenous dose of 1 mg.kg-1&nbsp;may be given over 2 min and repeated after 5 min, but giving an infusion of 2-4 mg.min-1&nbsp;to produce a plasma level of 2-4 mg. l-1&nbsp;is a more satisfactory technique. To avoid a long delay in achieving a steady state, a loading dose of approximately 1 mg.kg-1&nbsp;is usually given intravenously over 2 min at the outset.</p>