<p>Engagement in hazardous occupations requiring complete mental alertness such as driving or operating machinery should be avoided when taking Azelastine and Fluticasone&nbsp;Nasal Spray. Concurrent use of alcohol or other central nervous system (CNS) depressants with this Nasal Spray&nbsp;should also be avoided because of further decreased alertness and impairment of CNS. Hypercorticism and adrenal suppression with very high dosages or at the regular dosage in susceptible individuals may appear. If such changes occur, the spray should be discontinued slowly.</p>