<p><strong>Patients with renal impairment</strong>: No dose adjustment is necessary for patients with mild to moderate renal impairment (creatinine clearance &gt;30 ml/min). Patients with severe renal impairment (creatinine clearance &lt;30 ml/min) should be treated with caution and receive no more than 5 mg once daily.<br />
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<strong>Patients with hepatic impairment</strong>: No dose adjustment is necessary for patients with mild hepatic impairment. Patients with moderate hepatic impairment (Child-Pugh score of 7 to 9) should be treated with caution and receive no more than 5 mg once daily.<br />
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<strong>Potent inhibitors of cytochrome P450 3A4</strong>: The maximum dose of Solifenacin Succinate should be limited to 5 mg when treated simultaneously with Ketoconazole or therapeutic doses of other potent CYP3A4 inhibitors e.g. Ritonavir, Nelfinavir, Itraconazole. Solifenacin Succinate tablet should be taken orally and should be swallowed whole with liquids. It can be taken with or without food.</p>