<p><strong>Initial dose</strong>: 200-400 mg daily in two divided doses, with meals or milk, gradually increasing when necessary to full maintenance dosage in one week.<br />
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<strong>Maintenance dose</strong>: 400 mg daily, given in two divided doses, as above. This dosage may be increased to 800 mg daily, if necessary, and may sometimes be reduced to as low as 200 mg daily after the&nbsp;blood&nbsp;urate&nbsp;level has been controlled. Treatment should be continued without interruption even in the presence of&nbsp;acute&nbsp;exacerbations, which can be concomitantly treated with phenylbutazone or&nbsp;colchicine. Patients previously controlled with other uricosuric therapy may be transferred to Anturane (sulfinpyrazone) at full maintenance dosage.</p>