<p><strong>Hepatic impaired patient</strong>: Metoprolol should be used with caution in patients with impaired hepatic function.<br />
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<strong>Pediatric Use</strong>: No clinically relevant differences in the adverse event profile were observed for pediatric patients aged 6 to 16 years as compared with adult patients. Safety and effectiveness of Metoprolol have not been established in patients &lt;6 years of age.<br />
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<strong>Geriatric Use</strong>: There were no notable differences in efficacy or the rate of adverse events between older and younger patients.</p>