<p><strong>Dose adjustment and monitoring</strong>: Blood glucose should be monitored in all patients treated with insulin. Insulin regimens should be modified cautiously and only under medical supervision.<br />
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<strong>Administration</strong>: Insulin glargine must not be diluted or mixed with any other insulin or solution. It should not be administered subcutaneously via an insulin pump or intravenously because severe hypoglycemia can occur.<br />
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<strong>Renal or hepatic impairment</strong>: Reduction in the Insulin glarginedose may require in these cases.</p>