<p>Hormone replacement therapy (HRT) should not be started in the presence of any of the conditions listed below. The product should be stopped immediately, if any of the conditions appear during HRT use.</p>

<ul>
	<li>Undiagnosed abnormal genital bleeding</li>
	<li>Known or suspected cancer of the breast</li>
	<li>Known or suspected premalignant conditions or malignancies, if sex steroid-influenced</li>
</ul>

<p>The excess risk disappears within a few years after stopping HRT. HRT increases the density of mammographic images which may adversely affect the radiological detection of breast cancer in some cases.<br />
<br />
Endometrial cancer: Prolonged exposure to unopposed estrogens increases the risk of development of endometrial hyperplasia or carcinoma. The addition of DRSP opposes the development of endometrial hyperplasia caused by estrogens.<br />
<br />
Liver tumors: In rare cases benign, and even more rarely, malignant liver tumors have been observed after the use of hormonal substances such as those contained in HRT products. In isolated cases, these tumors led to life-threatening intra-abdominal hemorrhage.</p>