<p><strong>Intravenous</strong>: Dissolve Polymyxin B 500,000 units in 300 to 500 ml solutions for parenteral Dextrose injection 5% for continuous drip.<br />
<br />
<strong>Intramuscular</strong>: Dissolve Polymyxin B 500,000 units in 2 ml 0.9% Sodium Chloride solution. It is not recommended routinely because of severe pain at injection site, particularly in infants and children.<br />
<br />
<strong>Intrathecal</strong>: Dissolve Polymyxin B 500,000 units in 10 ml 0.9% Sodium Chloride solution for 50,000 units per ml dosage unit.<br />
<br />
In meningeal infections, Polymyxin B Sulfate should be administered only by the intrathecal route.<br />
<br />
For IV route:</p>

<ul>
	<li><strong>Adult &amp; Children (Normal kidney function)</strong>: Dose (Units/kg/day) is 15,000-25,000(Not exceed 25,000) and Dosage frequency/Duration is infusions may be given every 12 hours over a period of approximately 60 to 90 minutes.</li>
	<li><strong>Adult &amp; Children (Renal impairment)</strong>: Dose (Units/kg/day) is Less than 15,000 and Dosage frequency/Duration is Infusions may be given every 12 hours over a period of approximately 60 to 90 minutes.</li>
	<li><strong>Infants (Normal kidney function)</strong>: Dose (Units/kg/day) is Maximum 40,000</li>
</ul>

<p>For IM route:</p>

<ul>
	<li><strong>Adult &amp; Children</strong>: Dose (Units/kg/day) is 25,000-30,000 and Dosage frequency/Duration is Dose should be reduced in the presence of renal impairment. The dosage may be divided and given at either 4 or 6 hour intervals.</li>
	<li><strong>Infants (Normal kidney function)</strong>: Dose (Units/kg/day) is Maximum 40,000</li>
</ul>

<p>For Intrathecal:</p>

<ul>
	<li><strong>Children under 2 years of age</strong>: Dosage frequency/Duration is 20,000 units once daily, intrathecally for 3 to 4 days or 25,000 units once every other day. Continue with a dose of 25,000 units once every other day for at least 2 weeks after cultures of the cerebrospinal fluid are negative and sugar content has returned to normal.</li>
	<li><strong>Adults and children over 2 years of age</strong>: 50,000 units once daily for 3 to 4 days, then 50,000 units once every other day for at least 2 weeks after cultures of the cerebrospinal fluid are negative and sugar content has returned to normal.</li>
</ul>