<p>ln combined therapy, clonidine should not be discontinued unitil several days&nbsp;after withdrawal of Sotalol. Use with great caution with drugs that also prolong OT interval, e.g.&nbsp;disopyramide, amiodarone, Class I antiarrhythmic agents, calcium antagonists of the verapamil&nbsp;type or tricyclic antidepressants. Interactions also occur with phenothiazines, terfenadine,&nbsp;astemizole and diltiazem. Concomitant use of reserpine, guanethidine, or alpha methyldopa&nbsp;requires close monitoring for evidence of hypotension and/or marked bradycardia, syncope.&nbsp;Hypoglycemia may occur and the dosage of insulin or antidiabetic drugs may require adjustment.</p>