<p><strong>Pediatric use</strong>: The dose of Acyclovir IV injection in children aged 1-12 years should be calculated on the basis of body surface area. Children in this age group with Herpes simplex infections (except Herpes simplex encephalitis) or Varicella zoster infections should be given Acyclovir IV Infusion in doses of 250 mg/m2&nbsp;(equivalent to 5 mg/kg in adults). Immunocompromised children in this age group with Varicella zoster virus infection or with Herpes simplex encephalitis should be given Acyclovir IV Infusion in doses of 500 mg/m2&nbsp;(equivalent to 10 mg/kg in adults). Children with impaired renal function require an appropriately modified dose, according to the degree of impairment.<br />
&nbsp;<br />
<strong>Geriatric use</strong>: No data are available on this age group. However, as creatinine clearance is often low in the elderly, special attention should be given to dosage reduction.<br />
<br />
<strong>In patients with renal impairment</strong>:&nbsp;Acyclovir should be administered with caution since the drug is excreted through the kidneys. The following modifications in dosage are suggested:</p>

<ul>
	<li>CrCl: 25-50 ml/min: 5 or 10 mg/kg every 12 hours</li>
	<li>CrCl: 10-25 ml/min: 5 or 10 mg/kg every 24 hours</li>
	<li>CrCl: 0-10 ml/min: 2.5 or 5 mg/kg every 24 hours and after dialysis.</li>
</ul>