<p><strong>Nebivolol</strong>: Beta-blockers should not be used in patients with untreated Congestive Heart Failure (CHF) &amp; bradycardia. In patients with Chronic Obstructive Pulmonary Diseases (COPD), beta-blockers should be used with caution as airway constriction may be aggravated.<br />
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<strong>Hydrochlorothiazide</strong>: In patients with renal disease, thiazides may increase azotaemia. If progressive renal impairment becomes evident, careful reappraisal of therapy is necessary. Thiazides can cause fluid or electrolyte imbalance. Thiazides may decrease urinary calcium excretion and may cause slight elevation of serum calcium in the absence of known disorders of calcium metabolism.</p>