<p><strong>Treatment of anemia in chronic renal failure</strong>: Erythropoietin is administered to maintain hemoglobin concentration between 11 to 12 g/dl and hematocrit of 33-36 % in adults.<br />
<br />
Starting dose:</p>

<ul>
	<li>Adult: Usually 50 to 100 lU/kg three times in a week (TIW) by IV or Subcutaneous route.</li>
	<li>Pediatric: 50 lU/kg TIW by IV or Subcutaneous route.</li>
</ul>

<p>Dose adjustment: Dose should be increased if hematocrit doses not increase by 5 to 6 points after 8 weeks therapy, and hematocrit is below suggested target range. Dose should be reduced when hematocrit approaches 36% or hematocrit increases &gt;4 points in any 2-week period.<br />
<br />
Maintenance dose: Maintenance dose must be individualized for each patient. In patients undergoing dialysis, the median maintenance dose is 75 lU/kg TIW, with a range from 12.5 to 525 lU/kg TIW as directed by the physician. In CRF patients not on dialysis, maintenance dose is 75 to 150 lU/kg/week.<br />
<br />
<strong>Treatment of Anemia in Cancer Patients on Chemotherapy</strong>:<br />
<br />
Starting dose:</p>

<ul>
	<li>Adult: 150 lU/kg TIW by Subcutaneous route or 40,000 IU Subcutaneous route weekly.</li>
	<li>Pediatric: 25 to 300 lU/kg 3 to 7 times per week by Subcutaneous or IV route.</li>
</ul>

<p>Dose adjustment: If the response is not satisfactory, the dose should be increased to 300 lU/kg TIW. If the hematocrit exceeds 40%, the dose should be withheld until the hematocrit falls to 36%.The dose should be reduced to 25% when treatment is resumed and titrated to maintain the desired hematocrit.<br />
<br />
Surgery Patients: The recommended dose is 300 lU/kg/day subcutaneously for 10 days before surgery, on the day of surgery, and for 4 days after surgery. An alternate dose schedule is 600 lU/kg subcutaneously in once weekly dose (21, 14, and 7 days before surgery) plus a fourth dose on the day of surgery.<br />
<br />
<strong>Zidovudine-treated HIV-infected Patients</strong>:<br />
Starting dose</p>

<ul>
	<li>Adult: 100 lU/kg as an IV or Subcutaneous injection TIW for 8 weeks.</li>
	<li>Pediatric: 50 to 400 lU/kg 2 to 3 times per week by Subcutaneous or IV route.</li>
</ul>

<p>Dose adjustment: If the response is not satisfactory, the dose should be increased by 50-1001U/kg TIW. Response should be evaluated every 4 to 8 weeks thereafter and the dose adjusted accordingly by 50 to 100 lU/kg increments TIW.<br />
<br />
Maintenance dose: The dose is titrated to maintain the hematocrit between 33-36%.</p>

<ul>
	<li>Do not shake. It is not necessary to shake Erythropoietin. Prolonged vigorous shaking may denature any glycoprotein, rendering it biologically inactive.</li>
	<li>Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration.</li>
	<li>Administer as an intravenous injection over 1-2 minutes. In patients on dialysis, the injection should follow the dialysis procedure. Slow injection over 5 minutes may be beneficial to those who experience flu-like symptoms.</li>
	<li>Do not administer by intravenous infusion or in conjunction with other drug solutions.</li>
	<li>For the subcutaneous route, a maximum of 1 ml_ at one injection site should generally not be exceeded. In the case of larger volumes, more than one site should be chosen for the injection.</li>
</ul>

<p><a href="https://medex.com.bd/news/104/danger-of-taking-medication-without-doctors-advice" target="_blank"><em>* চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন</em></a>&#39;</p>