<p><strong>Impaired Hepatic Function</strong>: As the majority of Valsartan is eliminated in the bile, care should be exercised in patients with mild to moderate hepatic impairment including biliary obstructive disorder.<br />
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<strong>Impaired Renal Function</strong>: Dosage reduction or discontinuation may be required with patients having pre-existing renal impairment.<br />
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<strong>Heart Failure and Myocardial Infarction</strong>: Caution should be exercised when initiating therapy in patients with heart failure and post-myocardial infarction patients.</p>