<p>The dose of theophylline must be individualized on the basis of peak serum theophylline concentration measurements in order to achieve a dose that will provide maximum potential benefit with minimal risk of adverse effects. Most of the sustained release preparations may be administered every 12 hours in adults while administration every 8 hours may be necessary in some children with markedly rapid hepatic<br />
metabolism of theophylline. The recommended maintenance dose within accepted therapeutic range is as follows :</p>

<ul>
	<li>16 years or older: 10 mg/Kg/day (Do not exceed 900 mg/day)</li>
	<li>12 years-15 years: 13 mg/Kg/day</li>
	<li>9-11 years: 16 mg/Kg/day</li>
	<li>1 year-8 years: 24-24 mg/Kg/day</li>
	<li>6 months-1 year: 12-18 mg/Kg/day</li>
	<li>1-6 months: 10 mg/Kg/day.</li>
</ul>