<p>Risperidone is a selective monoaminergic antagonist having a high affinity for serotoninergic 5-HT2&nbsp;and dopaminergic D2&nbsp;receptors. Risperidone binds also to alpha1&nbsp;adrenergic receptors and with lower affinity, to H1&nbsp;histamine and alpha2&nbsp;adrenergic receptors. Risperidone has no affinity for 8 cholinergic receptors. Risperidone, as a potent D2&nbsp;antagonist, improves the positive symptoms of schizophrenia but causes less depression of motor activity. Balanced central serotonin and dopamine antagonism may reduce extrapyramidal side effect liability and extend the therapeutic activity to the negative and affective symptoms of schizophrenia.</p>