<p>Dosage Adjustment for Patients With Moderate to Severe&nbsp;Renal Insufficiency-<br />
<br />
Active Duodenal Ulcer, GERD and Benign Gastric Ulcer:</p>

<ul>
	<li><strong>CrCl 20-50 ml/min</strong>: 150 mg daily</li>
	<li><strong>CrCl &lt;20 ml/min</strong>: 150 mg every other day</li>
</ul>

<p>Maintenance Therapy:</p>

<ul>
	<li><strong>CrCl 20-50 ml/min</strong>: 150 mg every other day</li>
	<li><strong>CrCl</strong>&nbsp;<strong>&lt;20 mL/min</strong>: 150 mg every 3 days</li>
</ul>

<p>Some elderly patients may have creatinine clearances of less than 50 ml/min, and, based on pharmacokinetic data in patients with renal impairment, the dose for such patients should be reduced accordingly. The clinical effects of this dosage reduction in patients with renal failure have not been evaluated.</p>