<p><strong>Oral-&nbsp;</strong>Moderate to severe pain:&nbsp;5-20 mg 4 hrly. Extended-release: 5-20 mg 12 hrly. Dosage is dependent on the severity of pain.<br />
<br />
<strong>Intraspinal-&nbsp;</strong>Moderate to severe pain:&nbsp;Initially, 5 mg epidural inj; after 1 hr, additional doses of 1-2 mg may be given up to a total dose of 10 mg/24 hr if pain relief is unsatisfactory. A dose of 20-30 mg daily may be required in some patients. Liposomal inj: 10-20 mg depending on the type of surgery.<br />
<br />
<strong>Intrathecal-&nbsp;</strong>Moderate to severe pain: 0.2-1 mg once daily or 1-10 mg daily for patients with opioid tolerance. Some patients may require a dose of up to 20 mg daily.<br />
<br />
<strong>Intravenous-&nbsp;</strong>Acute pulmonary oedema:</p>

<ul>
	<li><strong>Adult:</strong>&nbsp;5-10 mg via slow inj at 2 mg/min.</li>
	<li><strong>Elderly:</strong>&nbsp;Half of the usual adult dose.</li>
</ul>

<p><strong>Intravenous-&nbsp;</strong>Pain associated with myocardial infarction:</p>

<ul>
	<li><strong>Adult:</strong>&nbsp;5-10 mg at 1-2 mg/min followed by a further 5-10 mg as necessary.</li>
	<li><strong>Elderly:</strong>&nbsp;Half of the usual adult dose.</li>
</ul>

<p><strong>Parenteral-&nbsp;</strong></p>

<ul>
	<li><strong>Moderate to severe pain</strong>:&nbsp;5-20 mg; 2.5-10 mg via slow IV inj over 4-5 min with patient in recumbent position or a starting dose of 1-2 mg/hr via continuous IV infusion (max: 100 mg/day; 4 g/day in cancer patients). Doses may be adjusted according to severity of pain and patient&#39;s response.</li>
	<li><strong>Premedication in surgery</strong>:&nbsp;Up to 10 mg, given 60-90 min before operation.</li>
</ul>

<p>&nbsp;</p>

<p><strong>Administration</strong></p>

<p>May be taken with or without food. May be taken with meals to reduce GI discomfort.</p>