<p><strong>Impaired Renal Function</strong>: This capsule should be used with caution in patients with severe renal disease.<br />
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<strong>Hyperkalemia</strong>: This may occur in only a few patients but generally are reversible.<br />
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<strong>Patients With Hepatic Failure</strong>: Since Amlodipine is extensively metabolized by the liver and the plasma elimination half-life (t &frac12;) is 56 hours in patients with impaired hepatic function, caution should be exercised when administering this capsule to patients with severe hepatic impairment.<br />
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<strong>Cough</strong>: ACE inhibitor-induced cough should be considered in the differential diagnosis of cough.<br />
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<strong>Surgery/Anesthesia</strong>: In patients undergoing surgery or during anesthesia with agents that produce hypotension, Benazepril will block the angiotensin II formation that could otherwise occur secondary to compensatory renin release. Hypotension that occurs as a result of this mechanism can be corrected by volume expansion.<br />
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<strong>Carcinogenesis, Mutagenesis, Impairment of Fertility</strong>: No evidence of carcinogenicity, mutagenicity or impairment of fertility was found when the Benazepril/Amlodipine combination were given orally.</p>