<p>General Risk of Bleeding: Drugs that inhibit platelet function including Ticagrelor increase the risk of bleeding.<br />
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Concomitant Aspirin Maintenance Dose: Use of Ticagrelor with maintenance doses of aspirin above 100 mg decreased the effectiveness of Ticagrelor. Therefore, after the initial loading dose of aspirin (usually 325 mg), use Ticagrelor with a maintenance dose of aspirin of 75-100 mg.<br />
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Moderate Hepatic Impairment: Ticagrelor has not been studied in patients with moderate hepatic impairment.<br />
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Discontinuation of Ticagrelor: Discontinuation of Ticagrelor will increase the risk of myocardial infarction, stent thrombosis, and death.</p>