<p><strong>Pediatric use</strong>: Safety and effectiveness in pediatric patients have not been established.<br />
<br />
Renal Impairment:</p>

<ul>
	<li><strong>Mild to moderate (CrCl 30-80 mL/min)</strong>: Dose titration needed</li>
	<li><strong>Severe (CrCl &lt;30 mL/min)</strong>: Contraindicated</li>
</ul>

<p>Hepatic Impairment:</p>

<ul>
	<li><strong>Mild</strong>: Dose titration needed</li>
	<li><strong>Moderate to severe</strong>: Contraindicated</li>
</ul>