<p><strong>Teeth and bone</strong>: Tetracycline can cause depression of bone growth, permanent graybrown discoloration of the teeth and enamel hypoplasia when given during tooth development (i.e. during the later half of pregnancy, during infancy and in childhood).<br />
<br />
Hypersensitivity reactions such as anaphylaxis, urticaria and rashes are uncommon. Photosensitivity reactions consisting of a red rash on areas exposed to intense sunlight can occur with Tetracycline.<br />
<br />
<strong>Gastrointestinal effects</strong>: Epigastric distress and nausea are commonly seen after oral administration, and these symptoms are somewhat dose related. Vomiting can occur.<br />
<br />
<strong>Accentuated prerenal azotemia</strong>: Tetracycline appears to aggravate pre-existing renal failure by inhibiting protein synthesis, which increases the azotemia from amino acid metabolism.<br />
<br />
Superinfections with oral and anogenital candidiasis are relatively common in patients taking Tetracycline.<br />
<br />
<strong>Esophageal ulcerations</strong>: In most cases, the patients were taking the capsules with little or no fluid before going to bed. To help minimize this, oral doses should be given with adequate amounts of fluid.</p>