<p>Contraindicated in pregnancy &amp; lactation. There are no data from the use of ruxolitinib in pregnant women. Animal studies have shown that ruxolitinib is embryotoxic and foetotoxic.&nbsp;<br />
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ruxolitinib must not be used during breast-feeding and breast-feeding should therefore be discontinued when treatment is started. It is unknown whether ruxolitinib and/or its metabolites are excreted in human milk. A risk to the breast-fed child cannot be excluded. Available pharmacodynamic/toxicological data in animals have shown excretion of ruxolitinib and its metabolites in milk<br />
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Fertility: There are no human data on the effect of ruxolitinib on fertility. In animal studies, no effect on fertility was observed.</p>