<ul>
	<li>The use of promethazine should be avoided in children and adolescents with signs and symptoms suggestive of Reye&rsquo;s syndrome.</li>
	<li>Promethazine may thicken or dry lung secretions and impair expectoration. It should therefore be used with caution in patients with asthma, bronchitis or bronchiectasis.</li>
	<li>Use with care in patients with severe coronary artery disease.</li>
	<li>Use with care in patients with narrow angle glaucoma.</li>
	<li>Use with care in patients with epilepsy.</li>
	<li>Use with care in patients with hepatic insufciency.</li>
	<li>Use with care in patients with renal insufciency.</li>
	<li>Caution should be exercised in patients with bladder neck obstruction.</li>
	<li>Caution should be exercised in patients with pyloro-duodenal obstruction.</li>
</ul>