<p><strong>Ocular</strong>: Discomfort of short duration, occasional tearing has been reported. Rare instances of decreased corneal sensitivity, erythema, itching sensation, corneal punctuate staining, keratitis, edema and photophobia have been reported.<br />
<br />
<strong>Systemic</strong>: Systemic reactions following administration of Betaxolol hydrochloride ophthalmic solution 0.5% have been rarely reported. These include:</p>

<ul>
	<li>Cardiovascular: bradycardia, heart block, congestive heart failure.</li>
	<li>Respiratory: bronchospasm, respiratory failure.</li>
	<li>Others: Hives, toxic epidermal necrolysis, hair loss and glossitis.</li>
</ul>