<p><strong>Weight Gain</strong>: Weight gain is a frequent side effect of Megestrol Acetate. This gain has been associated with increased appetite and is not necessarily associated with fluid retention.<br />
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<strong>Thromboembolic Phenomena</strong>: Thromboembolic phenomena including thrombophlebitis and pulmonary embolism (in some cases fatal) have been reported.<br />
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<strong>Glucocorticoid Effects</strong>: The glucocorticoid activity of Megestrol Acetate has not been fully evaluated. Clinical cases of new onset diabetes mellitus, exacerbation of preexisting diabetes mellitus, and overt Cushing&rsquo;s syndrome have been reported in association with the chronic use of Megestrol Acetate. In addition, clinical cases of adrenal insufficiency have been observed in patients receiving or being withdrawn from chronic Megestrol Acetate therapy in the stressed and non-stressed state.<br />
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<strong>Other</strong>: Nausea, dyspnea, tumor flare, hyperglycemia, glucose intolerance, alopecia, hypertension, carpal tunnel syndrome, mood changes, hot flashes, malaise, asthenia, lethargy, sweating and rash.</p>