<p>Ipratropium bromide is an anticholinergic agent that inhibits vagally mediated reflexes by antagonizing the action of acetylcholine at the cholinergic receptor. In humans, Ipratropium bromide has antisecretory properties and when applied locally, inhibits secretions from the serous and seromucous glands lining the nasal mucosa. Ipratropium bromide is a quaternary amine that minimally crosses the nasal and gastrointestinal membrane and the blood-brain barrier, resulting in a reduction of the systemic anticholinergic effects (e.g. neuroleptic, ophthalmic, cardiovascular, and gastrointestinal effects) that are seen with tertiary anticholinergic amines.</p>