<p>Venlafaxine tablets is indicated for the treatment of major depressive disorder.<br />
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The efficacy of venlafaxine tablets, in the treatment of major depressive disorder was established in 6 week controlled trials of adult outpatients whose diagnoses corresponded most closely to the&nbsp;DSM-III or DSM-III-R category of&nbsp;major depression&nbsp;and in a 4 week controlled trial of inpatients meeting diagnostic criteria for major depression with&nbsp;melancholia<br />
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A major depressive episode implies a prominent and relatively persistent depressed or dysphoric mood that usually interferes with daily functioning (nearly every day for at least 2 weeks); it should include at least 4 of the following 8 symptoms: change in appetite, change in sleep, psychomotor agitation or retardation, loss of interest in usual activities or decrease in sexual drive, increased fatigue, feelings of guilt or worthlessness, slowed thinking or impaired concentration, and a suicide attempt or suicidal ideation.<br />
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The efficacy of venlafaxine hydrochloride extended-release capsules in maintaining an&nbsp;antidepressant&nbsp;response for up to 26 weeks following 8 weeks of acute treatment was demonstrated in a placebocontrolled trial. The efficacy of venlafaxine tablets in maintaining an antidepressant response in patients with&nbsp;recurrent&nbsp;depression who had responded and continued to be improved during an initial 26 weeks of treatment and were then followed for a period of up to 52 weeks was demonstrated in a second placebo-controlled trial (see&nbsp;Clinical Trials). Nevertheless, the physician who elects to use venlafaxine tablets / extended-release capsules for extended periods should periodically re-evaluate the long-term usefulness of the drug for the individual patient.</p>