<p><strong>Insulin</strong>: Patients taking danazol may show increased insulin resistance. The significance of this is not known but such patients should be carefully monitored.<br />
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<strong>Estrogens and progestogens</strong>: Theoretically danazol may interact with exogenous estrogens and/or progestogens. It has been suggested that danazol acts by binding to estrogen, progesterone or androgen receptors at various levels in the hypothalamic pituitary-ovarian axis. Therefore, women of child bearing age should use effective, non hormonal methods of contraception.<br />
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<strong>Anticonvulsant therapy</strong>: Danazol may affect the plasma concentration of carbamazepin and possibly the patient&#39;s response to this agent and to phenytoin. A similar interaction is possible for phenobarbital.<br />
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<strong>Antihypertensive therapy</strong>: Danazol can oppose the action of antihypertensive agents, possibly through effects on fluid retention.<br />
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<strong>Cyclosporine</strong>: Danazol can increase the plasma concentration of cyclosporine.<br />
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<strong>Migraine therapy</strong>: Danazol itself may provoke migraine and it may possibly reduce the effectiveness of medication to prevent the condition.</p>