<p><strong>Bronchospasm</strong>: The combination should be used with caution in patients with airway obstruction.<br />
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<strong>Renal impairment</strong>: The combination can be used in patients with renal impairment. However, caution may be necessary if the creatinine clearance is less than 30 ml/min because of possible reduction in the excretion of unchanged Atenolol.<br />
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<strong>Hepatic impairment</strong>: Caution may be necessary in the use of the combination in patients with severe liver damage because of prolongation of the elimination half-life of Amlodipine.<br />
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<strong>Drug withdrawal</strong>: Since coronary heart disease may exist without being recognized, patients should be warned against stopping the drug suddenly. Any discontinuation should be gradual and under observation.</p>