<p><strong>Patients with renal impairment</strong>: &nbsp;The dose should be reduced. This can be achieved by either reducing the total daily dose, or by increasing the dosage interval in accordance with the creatinine clearance. For example:</p>

<ul>
	<li><strong>CrCl &lt;15 ml/min</strong>: Contraindicated</li>
	<li><strong>CrCl 15-35&nbsp;ml/min</strong>:&nbsp;100 mg every 2 to 3 days</li>
	<li><strong>CrCl &gt;35&nbsp;ml/min</strong>:&nbsp;100mg every day</li>
</ul>

<p><strong>Patients with hepatic impairment</strong>: Use with caution</p>