<p>Nicorandil tablet is contra-indicated in patients who have shown&nbsp;hypersensitivity to Nicorandil. Use is contra-indicated with cardiogenic shock and acute&nbsp;myocardial infarction with acute left ventricular failure and low filling pressures, in patients with&nbsp;hypotension, and in patients taking phosphodiesterase-5 inhibitors because concurrent use of&nbsp;Nicorandil can lead to a serious drop in blood pressure. Warnings and precautions: Nicorandil&nbsp;should be used with caution in patients who may have blood volume depletion or in those who&nbsp;present with low systolic blood pressure (below 100 mm Hg). The use of the drug in patients with&nbsp;cardiogenic shock, or acute myocardial infarction with acute left ventricular failure and low filling&nbsp;pressures should be avoided. Nicorandil should be discontinued and appropriate measures taken&nbsp;if mouth ulceration, stomatitis or persistent or severe buccal ulcerations, appear. Caution is&nbsp;advised for the use of Nicorandil in patients with glaucoma. The hypotensive effect of other&nbsp;vasodilators, tricyclic antidepressants or alcohol can be increased by administration in&nbsp;combination with Nicorandil. Therapeutic doses of Nicorandil may lower the blood pressure of&nbsp;hypertensive patients and Nicorandil therefore, as with other antianginal agents, should be used&nbsp;with care when prescribed with antihypertensive drugs. Animal mutagenicify and carcinogenicity&nbsp;studies have not revealed any adverse effect of Nicorandil when used under experimental&nbsp;conditions.</p>