<p><strong>ACE inhibitors</strong>: Concomitant administration of ACE inhibitors with potassium-sparing diuretics has been associated with severe hyperkalemia.<br />
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<strong>Alcohol, barbiturates, or narcotics</strong>: Potentiation of orthostatic hypotension may occur.<br />
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<strong>Corticosteroids, ACTH</strong>: Intensified electrolyte depletion, particularly hypokalemia, may occur.<br />
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<strong>Lithium</strong>: Lithium generally should not be given with diuretics. Diuretic agents reduce the renal clearance of lithium and add a high risk of lithium toxicity.<br />
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<strong>Digoxin</strong>: Spironolactone has been shown to increase the half-life of digoxin.</p>