<p>Several investigators have reported on the appetite enhancing property of Megestrol Acetate and its possible use in anorexia, cachexia. The precise mechanism by which Megestrol Acetate produces effects in anorexia and cachexia is unknown at the present time but some studies indicate there is a statistically significant negative correlation between the level of pro-inflammatory cytokines such as IL1&nbsp;IL6&nbsp;,TNF with various nutritional parameters and improvement in quality of life and wieght gain.<br />
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Plasma concentrations of Megestrol Acetate are dependent, not only on the method used, but also on intestinal and hepatic inactivation of the drug, which may be affected by factors such as intestinal tract motility, intestinal bacteria, antibiotics administered, body weight, diet, and liver function. The effect of food on the bioavailability of Megestrol Acetate Oral Suspension has not been evaluated. The major route of drug elimination in human is urine. The mean elimination half life ranged from 20 to 50 hours in healthy subject.</p>