<p><strong>Chronic lymphocytic leukaemia</strong>:&nbsp;100 mg/m2&nbsp;infused over 30-60 min on days 1 and 2 of a 28-day cycle for up to 6 cycles. For severe haematological or non-haematological toxicity: Reduce dose to 50 mg/m2&nbsp;on days 1 and 2 of each cycle. If severe haematological toxicity recurs, further reduce dose to 25 mg/m2&nbsp;on days 1 and 2 of each cycle. May consider dose re-escalation in subsequent cycles.<br />
<br />
<strong>Multiple myeloma</strong>:&nbsp;120-150 mg/m2&nbsp;infused over 30-60 min on days 1 and 2 of a 28-day cycle. IV or oral prednisone may be given at a dose of 60 mg/m2&nbsp;on days 1-4 of the cycle.<br />
<br />
<strong>Non-Hodgkin&#39;s lymphoma</strong>:&nbsp;120 mg/m2&nbsp;infused over 30-60 min on days 1 and 2 of a 21-day cycle for up to 8 cycles. For severe haematological or non-haematological toxicity: Reduced to 90 mg/m2&nbsp;on days 1 and 2 of each cycle. If severe toxicity recurs, further reduce dose to 60 mg/m2&nbsp;on days 1 and 2 of each cycle.</p>