<p><strong>Newly diagnosed glioblastoma multiforme</strong>: 75 mg/m&lt;sup&gt;2&lt;/sup&gt; for 42 days concomitant with focal radiotherapy followed by initial maintenance dose of 150 mg/m&lt;sup&gt;2&lt;/sup&gt; once daily for Days 1-5 of a 28-day cycle of Temozolomide for 6 cycles<br />
<br />
<strong>Refractory Anaplastic Astrocytoma</strong>: Initial dose 150 mg/m&lt;sup&gt;2&lt;/sup&gt; once daily for 5 consecutive days per 28-day treatment cycle.&nbsp;<br />
<br />
The recommended dose for Temozolomide as an intravenous infusion over 90 minutes is the same as the dose for the oral capsule formulation. Bioequivalence has been established only when Temozolomide for Injection was given over 90 minutes</p>

<p>&nbsp;</p>

<p><strong>Administration</strong></p>

<p>Should be taken on an empty stomach. Take at least 1 hr before meals.</p>