<p><strong>For both adults and children</strong>: a starting oral dose of 5mg/kg body weight divided into 2 or 3 equal doses per 24 hours will establish the patient&#39;s response and thereafter the dose can be increased until the symptoms and blood glucose level respond satisfactorily. Regular determinations of the blood glucose in the initial days of treatment are essential. The usual maintenance dose is 3-8mg/kg/day given in two or three divided doses.<br />
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<strong>Patients with renal impairment</strong>: Reduced doses may be required in patients with impaired renal function.<br />
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<strong>In children with leucine-sensitive hypoglycaemia</strong>: A dosage range of 15- 20mg/kg/day is suggested.<br />
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<strong>In adults with benign or malignant islet-cell tumours producing large quantities of insulin</strong>: High dosages of up to 1,000mg per day have been used.</p>