<p><strong>Elderly</strong>: It is advisable to reduce the initial dosage and maintain such patients on the minimal effective dose.<br />
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<strong>Hepatic impairment</strong>: These patients should be carefully monitored and kept at the minimal effective daily dosage.<br />
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<strong>Renal impairment</strong>: It is advisable to reduce the initial dosage and maintain such patients on the minimal effective dose.</p>