<p>Intramuscular-</p>

<p>Organophosphorus poisoning:</p>

<ul>
	<li><strong>Adult:</strong>&nbsp;Mild: 600 mg, repeat 1-2 times at 15 min intervals as needed. Severe: 1.8 g given as 3 inj of 600 mg in rapid succession. Persistent: May repeat the entire series (1.8 g) beginning 1 hr after admin of the last inj.</li>
	<li><strong>Child</strong>:&nbsp;&lt;40 kg: Mild: 15 mg/kg, repeat as needed every 15 min. Max: 45 mg/kg. Severe: 15 mg/kg, repeat twice in rapid succession to a total dose of 45 mg/kg. Persistent: May repeat the entire series (45 mg/kg) beginning 1 hr after admin of the last inj; &ge;40 kg: Same as adult dose.</li>
</ul>

<p>&nbsp;</p>

<p>Intravenous-</p>

<p>Organophosphorus poisoning:</p>

<ul>
	<li><strong>Adult:</strong>&nbsp;In combination with atropine: Loading dose: 1-2 g by infusion over 15-30 min or slow inj over at least 5 min, may repeat dose after 1 hr then 10-12 hrly, as needed. Administer as soon as the effects of atropine are observed. Maintain atropinisation for at least 48 hr.</li>
	<li><strong>Child:</strong>&nbsp;&le;16 yr Loading dose: 20-50 mg/kg (max: 2 g/dose) by inj over 15-30 min followed by 10-20 mg/kg/hr as continuous infusion. Alternatively, a repeat bolus of 20-50 mg/kg after 1 hr and repeated 10-12 hrly as needed; &gt;16 yr Same as adult dose.</li>
</ul>

<p>Poisoning or overdosage with compounds having muscarinic actions:</p>

<ul>
	<li><strong>Adult:</strong>&nbsp;Initially, 1-2 g, followed by 0.5-1 g/hr as infusion. Alternatively, the initial dose may be repeated after 1 hr and then 3-8 hrly as needed.</li>
</ul>