<p><strong>Renal Impairment</strong>: The dose for patients with severe renal impairment (GFR &lt;30 ml/min/1.73 m2) is 1 mg once daily. No dose adjustment is required for patients with mild to moderate renal impairment.<br />
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<strong>Hepatic Impairment</strong>: Patients with severe hepatic impairment (Child-Pugh class C) start with 1 mg once daily which may be increased to 2 mg if required to improve efficacy and if the 1 mg dose is well tolerated. No dose adjustment is required for patients with mild to moderate hepatic impairment.</p>