<p><strong>Patients with Impaired Renal Function</strong>:</p>

<ul>
	<li>Creatinine clearance 35 to 54 ml/min: 1 unit dose (based on unit doses of 500 mg &amp; 1 gm) Every 8 hours</li>
	<li>Creatinine clearance 11 to 34 ml/min: &frac12; unit dose (based on unit doses of 500 mg &amp; 1 gm) Every 12 hours</li>
	<li>Creatinine clearance 10 ml/min: &frac12; unit dose (based on unit doses of 500 mg &amp; 1 gm) Every 18 to 24 hours</li>
</ul>

<p><strong>Patients with Hepatic Insufficiency</strong>: No dosage adjustment is necessary in patients with hepatic insufficiency.<br />
<br />
<strong>Pediatric Dose</strong>: In pediatric patients, a total daily dosage of 25 to 50 mg per kg of body weight, divided into 3 or 4 equal doses, is effective for most mild to moderate infections. Total daily dosage may be increased to 100 mg per kg of body weight for severe infections. Safety for use in premature infants and in neonates has not been established.</p>