<p><strong>pediatric use</strong>: The safety and effectiveness of this combination preparation have not been studied in the pediatric population.<br />
<br />
<strong>Geriatric use</strong>:&nbsp; In general, dose selection for an elderly patient should be cautious, reflecting the greater frequency of decreased hepatic, renal, or cardiac function; of concomitant disease and multiple drug therapy.<br />
<br />
<strong>Use in Renal Disease</strong>: This combination preparation has not been studied in patients with impaired renal<br />
function. In patients with creatinine clearances of less than 30 ml/min, it is recommended that the dosing interval of this combination preparation be increased but not to exceed 2 tablets every 12 hours.<br />
<br />
<strong>Use in Hepatic Disease</strong>: This combination preparation has not been studied in patients with impaired hepatic function. The use of this combination preparation in patients with hepatic impairment is not recommended.</p>