<p>Micronized Progesterone Vaginal Pessary is structurally and biologically identical to natural endogenous progesterone.</p>

<ul>
	<li><strong>Absorption</strong>: Vaginal administration of Progesterone 400 mg every 12 h in healthy women has been shown effective in rapidly achieving and maintaining serum progesterone concentrations at physiological levels appropriate to the mid-luteal phase of the ovarian cycle and early pregnancy.</li>
	<li><strong>Distribution</strong>: Progesterone is approximately 96 % to 99 % bound to serum proteins, primarily to serum albumin and corticosteroid binding globulin.</li>
	<li><strong>Biotransformation</strong>: Progesterone is metabolized primarily by the liver largely to pregnanediols and pregnanolones. Pregnanediols and pregnanolones are conjugated in the liver to glucuronide and sulfate metabolites. Progesterone metabolites that are excreted in the bile may be deconjugated and may be further metabolized in the gut via reduction, dehydroxylation and epimerization.</li>
	<li><strong>Elimination</strong>: Progesterone undergoes renal and biliary elimination.</li>
</ul>