<p><strong>Hypotension</strong>: Symptomatic hypotension is possible, particularly in patients with severe aortic stenosis. Because of the gradual onset of action, acute hypotension is unlikely.<br />
<br />
<strong>Increased Angina or Myocardial Infarction</strong>: Worsening angina and acute myocardial infarction can develop after starting or increasing the dose of amlodipine, particularly in patients with severe obstructive coronary artery disease.<br />
<br />
<strong>Patients with Hepatic Failure</strong>: Because amlodipine is extensively metabolized by the liver and the plasma elimination half-life (t&frac12;) is 56 hours in patients with impaired hepatic function, titrate slowly when administering amlodipine to patients with severe hepatic impairment.</p>