<p><strong>Acute Ischemic Stroke</strong>: Alteplase is indicated for the treatment of acute ischemic stroke. Exclude intracranial hemorrhage as the primary cause of stroke signs and symptoms prior to initiation of treatment. Initiate treatment as soon as possible but within 3 hours after symptom onset.<br />
<br />
<strong>Acute Myocardial Infarction</strong>: Alteplase is indicated for use in acute myocardial infarction (AMI) for the reduction of mortality and the reduction of the incidence of heart failure.<br />
<br />
<strong>Pulmonary Embolism</strong>: Alteplase is indicated for the lysis of acute massive pulmonary embolism, defined as:</p>

<ul>
	<li>Acute pulmonary emboli obstructing blood flow to a lobe or multiple lung segments.</li>
	<li>Acute pulmonary emboli accompanied by unstable hemodynamics, e.g., failure to maintain blood pressure without supportive measures.</li>
</ul>