<p>Unexpected vaginal bleeding during therapy, patient with a pre-existing medical condition that might be adversely affected by fluid retention, patients with a history of treatment for clinical depression diabetic patient. It may decrease the level of the following endocrine biomarkers: Plasma /urinary steroid (eg: cortisol, oestrogen, pregnanediol , progesterone &amp; testosterone ) Plasma /urinary gonadotrophin (eg: LH &amp; FSH) &amp; sex&nbsp; hormonebinding- globulin (SHBG).</p>