<p>Preexisting bone marrow depression. Frequent monitoring of peripheral blood cell counts during treatment. Do not continue subsequent courses until neutrophils recover to &gt;1000 cells/mm3, platelets recover to &gt;100,000 cells/mm3&nbsp;and haemoglobin levels recover to 9.0 g/dl (with transfusion if needed). May impair ability to drive or operate machinery.</p>