<p>Irinotecan Injection is indicated as a component of first-line therapy in combination with 5-fluorouracil (5-FU) and&nbsp;leucovorin&nbsp;(LV) for patients with metastatic carcinoma of the colon or rectum.<br />
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Irinotecan is indicated for patients with metastatic carcinoma of the colon or rectum whose disease has recurred or progressed following initial fluorouracil-based therapy.</p>