<p>Promethazine Theoclate works by stopping histamine from binding to its receptors in&nbsp;an area in the brain known as the vomiting centre. The vomiting centre is responsible for causing feelings of sickness and for the vomiting reflex. It is activated when it receives nerve messages from the vestibular apparatus in the middle ear.<br />
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The vestibular apparatus provides constant feedback to the brain about the position of our body. When something disturbs the vestibular apparatus, such as movements of the head when travelling by boat or car, nerve signals are sent from the vestibular apparatus to the vomiting centre. This can cause the symptoms of motion sickness, such as nausea, dizziness or spinning sensations (vertigo) and vomiting.<br />
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By blocking the histamine receptors in the vomiting centre, Promethazine Theoclate&nbsp;prevents disturbances in the middle ear from activating the vomiting centre.</p>