<p>Lopinavir and Ritonavir tablets may be taken with or without food, swallowed whole and not chewed, broken, or crushed.<br />
<br />
Adult Patients:</p>

<ul>
	<li>400/100 mg (two 200/50 mg tablets) twice daily, or</li>
	<li>800/200 mg (four 200/50 mg tablets) once daily in patients with less than three lopinavir resistance-associated substitutions.</li>
</ul>

<p><strong>Concomitant Therapy in Adults Patients</strong>: Dose adjustments of Lopinavir and Ritonavir may be needed when co-administering with efavirenz, nevirapine, or nelfinavir.<br />
<strong>Do not use once daily administration of Lopinavir and Ritonavir in</strong>: HIV-1 infected patients with three or more of the following lopinavir resistance-associated substitutions: L10F/I/R/V, K20M/N/R, L24I, L33F, M36I, I47V, G48V, I54L/T/V, V82A/C/F/S/T, and I84V. Combination with efavirenz, nevirapine, nelfinavir, carbamazepine, phenobarbital, or phenytoin.</p>