<p>Based on clinical trials including large numbers of patients, Tenoxicam proved to be well tolerated in the recommended dose. Usually, the undesirable effects reported were mild and transient. In a small proportion of patients, the interruption of treatment due to undesirable effects was necessary. Local tolerance of Tenoxicam given parenterally was good. The following undesirable effects have been reported:<br />
<br />
Frequency is greater than 1%-</p>

<ul>
	<li>Gastrointestinal tract: gastric, epigastric and abdominal discomfort, dyspepsia, heartburn, nausea.</li>
	<li>Central nervous system: dizziness, headache.</li>
</ul>

<p>Frequency less than 1%-</p>

<ul>
	<li>Gastrointestinal tract: constipation, diarrhea, stomatitis, gastritis, vomiting, ulcers, Gl-bleeding including hematemesis and melena.</li>
	<li>Central nervous system: fatigue, sleep disturbances, appetite loss, dry mouth, vertigo.</li>
	<li>Skin: itching (also in the anal region after rectal administration), erythema, exanthema, rash, urticaria.</li>
	<li>Urinary tract and kidneys: increase in BUN or creatinine, edema.</li>
	<li>Liver and biliary tract: increased liver enzyme activity.</li>
	<li>Cardiovascular system: palpitations.</li>
</ul>

<p>Isolated cases (frequency less than 0.01%)-</p>

<ul>
	<li>Gastrointestinal tract: Gl-perforation.</li>
	<li>Central nervous system: visual disturbances.</li>
	<li>Skin: Stevens-Johnson and Lyell&#39;s syndrome, photosensitivity reaction, vasculitis.</li>
	<li>Blood: anemia, agranulocytosis, leukopenia, thrombocytopenia.</li>
	<li>Hypersensitivity reactions: dyspnea, asthma, anaphylaxis, angioedema.</li>
	<li>Cardiovascular system: elevated blood pressure, mainly in patients treated with cardiovascular drugs.</li>
	<li>Liver/Biliary tract: hepatitis.</li>
</ul>