<p>Because of the&nbsp;anticoagulant&nbsp;effect of Protamine sulfate , overdosage of this drug may theoretically result in&nbsp;hemorrhage. However, in one study, overdosage of 600 to 800 mg of&nbsp;intravenous&nbsp;Protamine sulfate had only minimal, transient effects on blood&nbsp;coagulation&nbsp;tests.The patient should be followed with coagulation studies and treated symptomatically. The LD50&nbsp;of Protamine sulfate is 100 mg/kg in mice.</p>