<p>Intravenous (Adult)-<br />
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<strong>Adjuvant therapy in stage III colon cancer:</strong>&nbsp;In combination with fluorouracil/ leucovorin: 85 mg/m2&nbsp;every 2 wk for 12 cycles. Dose to be given by IV infusion over 2-6 hr, dissolved in 250-500 ml of glucose 5%, every 2 wk; given for 12 cycles. After recovery from toxicity, reduce dose to 75 mg/m2. Administer before fluoropyrimidines.<br />
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<strong>Advanced colorectal cancer: In combination with fluorouracil/ leucovorin:</strong>&nbsp;85 mg/m2&nbsp;every 2 wk until disease progression or unacceptable toxicity. Dose to be given by IV infusion over 2-6 hr, dissolved in 250-500 ml of glucose 5%, . After recovery from toxicity, reduce dose to 65 mg/m2. Administer before fluoropyrimidines.</p>