<p><strong>Patient on potent CYP3A4 inhibitor-</strong></p>

<ul>
	<li>HER2 overexpressing advanced or metastatic breast cancer: Increase gradually from 1.25 g daily up to 4.5 g daily.</li>
	<li>HER2 overexpressing hormone receptor positive metastatic breast cancer: Increase gradually from 1.5 g daily up to 5.5 g daily.</li>
</ul>

<p><strong>Hepatic Impairment (Severe)-</strong></p>

<ul>
	<li>HER2 overexpressing advanced or metastatic breast cancer: 750 mg once daily.</li>
	<li>HER2 overexpressing hormone receptor positive metastatic breast cancer: 1 g once daily.</li>
</ul>