<p>One case of deliberate overdosage with Ticlopidine has been reported by a foreign postmarketing surveillance program. A 38-year-old male took a single 6000-mg dose of Ticlopidine (equivalent to 24 standard 250-mg tablets). The only abnormalities reported were increased bleeding time and increased&nbsp;SGPT. No special&nbsp;therapy&nbsp;was instituted and the patient recovered without&nbsp;sequelae.<br />
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Single oral doses of ticlopidine at 1600 mg/kg and 500 mg/kg were&nbsp;lethal&nbsp;to rats and mice, respectively. Symptoms of&nbsp;acute&nbsp;toxicity&nbsp;were GI&nbsp;hemorrhage, convulsions, hypothermia, dyspnea, loss of equilibrium and&nbsp;abnormal&nbsp;gait.</p>