<p><strong>Adults</strong>: The usual dosage is 3000 mg daily, given in divided doses as follows:</p>

<ul>
	<li>Two doses of two 750 mg tablets</li>
	<li>Two doses of three 500 mg tablets/capsules&nbsp;</li>
	<li>Three doses of two 500 mg tablets/capsules</li>
</ul>

<p>Some patients, e.g., the elderly, may require a lower dosage to achieve therapeutic blood concentrations and to avoid the more common side effects such as auditory.<br />
<br />
Alleviation of symptoms is gradual, and full benefit may not be evident for 3 to 4 days, when&nbsp;plasma&nbsp;salicylate levels have achieved steady state. There is no evidence for development of tissue tolerance (tachyphylaxis) but salicylate therapy may induce increased activity of metabolizing liver enzymes, causing a greater rate of salicyluric acid production and excretion, with a resultant increase in dosage requirement for maintenance of therapeutic&nbsp;serum&nbsp;salicylate levels.<br />
<br />
<strong>Children</strong>: Dosage recommendations and indications for Salsalate use in children have not been established.</p>

<p>&nbsp;</p>

<p><strong>Administration</strong></p>

<p>Should be taken with food. Take with food or milk.</p>