<p>Much less renal toxicity than cisplatin so no need for a vigorousm hydration schedule or forced diuresis. If AUC dosing is not used, dose should be reduced to 250 mg/m2&nbsp;for creatinine clearance of 41 to 59 ml/min and to 200 mg/m2&nbsp;for clearance of 16 to 40 ml/min. Corticosteroids &amp; antihistamines are employed to alleviate symptoms.</p>