<p><strong>Lactic acidosis</strong>: Lactic acidosis and severe hepatomegaly with steatosis, including fatal cases have been reported with the use of nucleoside analogues alone or in combination with antiretrovirals.<br />
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<strong>Exacerbations of hepatitis after discontinuation of treatment</strong>: Severe acute exacerbations of hepatitis B have been reported in patients who have discontinued anti-hepatitis B therapy, including Entecavir.</p>