<p>Intravenous (Adult)-</p>

<p>Malignancies:&nbsp;</p>

<ul>
	<li>Low dose regimen: 2-6 mg/kg wkly as a single dose;</li>
	<li>Moderate dose regimen: 10-15 mg/kg wkly as a single dose;</li>
	<li>High dose regimen: 20-40 mg/kg as a single dose every 10-20 days.</li>
</ul>

<p>Alternatively,</p>

<ul>
	<li>80-300 mg/m2&nbsp;daily as a single dose, or</li>
	<li>300-600 mg/m2&nbsp;wkly as a single dose, or</li>
	<li>600-1,500 mg/m2&nbsp;as a single dose or</li>
	<li>Short infusion at 10- to 20-day intervals.</li>
</ul>

<p>Oral&nbsp;(Child)-</p>

<p>Nephrotic syndrome:&nbsp;</p>

<ul>
	<li>2 mg/kg daily for 8-12 wk.</li>
	<li>Max cumulative dose: 168 mg/kg.</li>
	<li>Max duration: 90 days.</li>
</ul>

<p>Oral&nbsp;(Adult)-</p>

<p>Malignancies:&nbsp;</p>

<ul>
	<li>Low dose regimen: 2-6 mg/kg wkly in divided dose.</li>
	<li>Alternatively, 100-300 mg daily in divided doses, or</li>
	<li>50-250 mg/m2&nbsp;daily or 80-300 mg/m2&nbsp;daily in divided doses.</li>
</ul>

<p>&nbsp;</p>

<p><strong>Administration</strong></p>

<p>Should be taken on an empty stomach. Preferably taken on an empty stomach, but may be taken with meals to minimise GI irritation. Ensure adequate fluid intake. Swallow whole.</p>