<p><strong>Recommended Dosage for Renal Cell Carcinoma</strong>: The recommended dosage of Cabozantinib is 60 mg once daily without food until the patient no longer experiences clinical benefit or experiences unacceptable toxicity.<br />
<br />
<strong>Recommended Dosage for Hepatocellular Carcinoma</strong>: The recommended dosage of Cabozantinib is 60 mg once daily without food until disease progression or unacceptable toxicity.</p>

<p>&nbsp;</p>

<p><strong>Administration</strong></p>

<ul>
	<li>Stop treatment with Cabozantinib at least 28 days prior to scheduled surgery, including dental surgery</li>
	<li>Do not substitute Cabozantinib tablets with cabozantinib capsules.</li>
	<li>Do not administer Cabozantinib with food. Administer at least 1 hour before or at least 2 hours after eating</li>
	<li>Swallow Cabozantinib tablets whole. Do not crush Cabozantinib tablets.</li>
	<li>Do not take a missed dose within 12 hours of the next dose.</li>
	<li>Modify the dose for certain patients with hepatic impairment and for patients taking drugs known to strongly induce or inhibit CYP450</li>
</ul>