<p><strong>Adult</strong>: The usual therapeutic range is 10 to 20 mg twice daily. The usual&nbsp;starting dose is 10 mg twice daily, in the morning and in the evening&nbsp;preferably, and should be titrated upwards in accordance with patients needs, response and&nbsp;tolerance up to 40 mg twice daily, if necessary. An even lower starting dose of 5 mg twice daily may be used in patients particularly prone to headache.<br />
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<strong>Eldery</strong>: There are no&nbsp;special dosage requirements for elderly patients, but as with all medicines the lowest effective&nbsp;dose should be used. Nicorandil should be administered with care, using low starting&nbsp;dosages, in the elderly.<br />
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<strong>Children</strong>: Not recommended. Nicorandil should be used with&nbsp;caution in patients with serious hepatic dysfunction.<br />
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<strong>Hepatic Impairment</strong>: Dose reduction may be necessary.</p>