<p><strong>Use in Patients with Renal Impairment</strong>: The usual regimens of therapy with&nbsp;this combination may be followed as long as the patient&#39;s creatinine clearance is &gt;30 ml/min. In patients with more severe renal impairment, loop diuretics are preferred to thiazides. In that case, hydrochlorothiazide is not recommended.<br />
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<strong>Use in patients with Hepatic Impairment</strong>: Care should be taken in patient with hepatic impairment.</p>