<p>The recommended dose of Palbociclib is a 125 mg capsule taken orally once daily for 21 consecutive days followed by 7 days off treatment to comprise a complete cycle of 28 days. Palbociclib should be taken with food. Patients should be encouraged to take their dose of Palbociclib at approximately the same time each day. For men treated with combination Palbociclib plus aromatase inhibitor therapy, consider treatment with an LHRH agonist according to current clinical practice standards.<br />
<br />
Recommended Dose Modification for Adverse Reactions:</p>

<ul>
	<li>Recommended Starting Dose: 125 mg/day</li>
	<li>First Dose Reduction: 100 mg/day</li>
	<li>Second Dose Reduction: 75 mg/day</li>
</ul>

<p>If further dose reduction below 75 mg/day is required, discontinue. Or, as directed by the registered physician.<br />
<br />
Use in Children: Palbociclib is not indicated for use in children.</p>