<p>Dilute in 0.9% Sodium Chloride Injection to concentration of 4 mcg/mL prior to administration.<br />
<br />
To be administered only by health care providers skilled in the management of patients in the operating room setting.<br />
<br />
Administer intravenously using a controlled infusion device. Administration duration should not exceed 24 hours.<br />
<br />
Continuously monitor blood pressure, heart rate, and oxygen levels during administration and as clinically appropriate after discontinuation.<br />
<br />
Initiation of Procedural Sedation:</p>

<ul>
	<li><strong>More invasive procedures or awake fiberoptic intubation</strong>:&nbsp;1 mcg/kg over 10 minutes</li>
	<li><strong>Less invasive procedures such as ophthalmic surgery</strong>:&nbsp;0.5 mcg/kg over 10 minutes</li>
</ul>

<p>Maintenance of Procedural Sedation</p>

<ul>
	<li><strong>All procedures except awake fiberoptic intubation</strong>:&nbsp;Generally, initiate at 0.6 mcg/kg/hour and titrate to achieve desired clinical effect with dosages ranging from 0.2 to 1 mcg/kg/hour.&nbsp;</li>
	<li><strong>Awake fiberoptic intubation</strong>:&nbsp;Administer 0.7 mcg/kg/hour until the endotracheal tube is secured&nbsp;</li>
</ul>