<p><strong>Important Dosage Information</strong>: The dose reduction is needed for certain patients with renal or hepatic impairment. Lenvatinib should be taken once daily, with or without food, at the same time each day. If a dose is missed and cannot be taken within 12 hours, skip that dose and take the next dose at the usual time of administration.<br />
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<strong>Recommended Dosage for Differentiated Thyroid Cancer (DTC)</strong>: The recommended dosage of Lenvatinib is 24 mg orally once daily until disease progression or until unacceptable toxicity.<br />
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<strong>Recommended Dosage for Renal Cell Carcinoma (RCC)</strong>: The recommended dosage of Lenvatinib is 18 mg in combination with 5 mg Everolimus orally once daily until disease progression or until unacceptable toxicity.<br />
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<strong>Recommended Dosage for Hepatocellular Carcinoma (HCC)</strong>: The recommended dosage of Lenvatinib is based on actual body weight: 12 mg for patients greater than or equal to 60 kg or 8 mg for patients less than 60 kg. Lenvatinib should be taken orally once daily until disease progression or until unacceptable toxicity.<br />
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<strong>Recommended Dosage for Endometrial Carcinoma</strong>: The recommended dosage of Lenvatinib is 20 mg orally once daily, in combination with Pembrolizumab 200 mg administered as an intravenous infusion over 30 minutes every 3 weeks, until unacceptable toxicity or disease progression.</p>

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<p><strong>Administration</strong></p>

<p>Lenvatinib capsules can be swallowed whole or dissolved in a small glass of liquid. To dissolve in liquid, put capsules into 1 tablespoon of water or apple juice without breaking or crushing the capsules. Leave the capsules in the water or apple juice for at least 10 minutes. Stir for at least 3 minutes. After drinking the mixture, add 1 tablespoon of water or apple juice to the glass, swirl the contents a few times and swallow the water or apple juice.</p>