<p><strong>Pediatric use</strong>:&nbsp;Safety and effectiveness in pediatric patients have not been established.<br />
<br />
<strong>Geriatric use</strong>:&nbsp;In general, caution should be exercised when prescribing to elderly patients since they have greater frequency of decreased renal or cardiac function due to concomitant disease or other drug therapy.<br />
<br />
<strong>Dose Adjustment in Renal Impairment</strong>: the dosing interval of Adefovir should be adjusted in patients with baseline creatinine clearance &lt;50 ml/min using the following suggested guidelines:</p>

<ul>
	<li>CrCl &le; 50 ml/min: 10 mg</li>
	<li>CrCl 20-49 ml/min:&nbsp;10 mg&nbsp;every&nbsp;48 hours</li>
	<li>CrCl 10-19 ml/min:&nbsp;10 mg&nbsp;every 72 hours</li>
	<li>Haemodialysis patients:&nbsp;10 mg&nbsp;every&nbsp;7 days&nbsp;following dialysis</li>
</ul>