<p><strong>Pediatric Use</strong>: The safety and efficacy of Tetrabenazine in pediatric patients have not been established.<br />
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<strong>Geriatric Use</strong>: The pharmacokinetics of Tetrabenazine and its primary metabolites have not been formally studied in geriatric subjects.<br />
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<strong>Hepatic Impairment</strong>: Because the safety and efficacy of the increased exposure to Tetrabenazine and other circulating metabolites are unknown, it is not possible to adjust the dosage of Tetrabenazine in hepatic impairment to ensure safe use. The use of Tetrabenazine in patients with hepatic impairment is contraindicated.</p>