<p>Adult Dose</p>

<ul>
	<li><strong>Moderate to severe infection</strong>: 500 mg to 1 gm for every 6 to 8 hours</li>
	<li><strong>Mild infections caused by susceptible Gram-positive cocci</strong>: 250 mg to 500 mg for every 8 hours</li>
	<li><strong>Acute uncomplicated urinary tract infections</strong>: 1 gm for every 12 hours</li>
	<li><strong>Pneumococcal pneumonia</strong>: 500 mg for every 12 hours</li>
	<li><strong>Severe life-threatening infections (e.g. Endocarditis, Septicemia)</strong>: 1 gm to 1.5 gm for every 6 hours. In rare instances, doses up to 12 gm per day can be used</li>
</ul>

<p><strong>Perioperative Prophylactic Use</strong>: To prevent postoperative infection in contaminated or potentially contaminated surgery, recommended doses are:</p>

<ul>
	<li>1 gm IM or IV administered half hour to 1 hour prior to the start of surgery.</li>
	<li>For lengthy operative procedures (e.g. 2 hours or more), 500 mg to 1 gm IM or IV during surgery.</li>
	<li>500 mg to 1 gm IM or IV every 6 to 8 hours for 24 hours postoperatively.</li>
</ul>

<p>In surgery where the occurrence of infection may be particularly devastating (e.g. open-heart surgery and prosthetic arthroplasty), the prophylactic administration may be continued for 3 to 5 days following the completion of surgery.</p>