<p>Antidiarrheal prophylaxis: Initiate loperamide with the first dose of Neratinib and continue during first 2 cycles (56 days) of treatment. Instruct patients to maintain 1-2 bowel movements per day and on how to use antidiarrheal treatment regimens<br />
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<strong>Recommended dose</strong>: 240 mg (6 tablets) given orally once daily with food, continuously for one year. Dose interruptions and/or dose reductions are recommended based on individual safety and tolerability<br />
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<strong>Hepatic Impairment</strong>: Reduce starting dose to 80 mg in patients with severe hepatic impairment.</p>