<p>Impact of Other Drugs on Amlodipine-</p>

<ul>
	<li><strong>CYP3A Inhibitors</strong>: Co-administration with CYP3A inhibitors (moderate and strong) results in increased systemic exposure to amlodipine and may require dose reduction. Monitor for symptoms of hypotension and edema when amlodipine is co-administered with CYP3A inhibitors to determine the need for dose adjustment&nbsp;</li>
	<li><strong>CYP3A Inducers</strong>: No information is available on the quantitative effects of CYP3A inducers on amlodipine. Blood pressure should be closely monitored when amlodipine is co-administered with CYP3A inducers.</li>
	<li><strong>Sildenafil</strong>: Monitor for hypotension when sildenafil is coadministered with amlodipine.</li>
</ul>

<p>Impact of Amlodipine on Other Drugs-</p>

<ul>
	<li><strong>Simvastatin</strong>: Co-administration of simvastatin with amlodipine increases the systemic exposure of simvastatin. Limit the dose of simvastatin in patients on amlodipine to 20 mg daily.</li>
	<li><strong>Immunosuppressants</strong>: Amlodipine may increase the systemic exposure of cyclosporine or tacrolimus when co-administered. Frequent monitoring of trough blood levels of cyclosporine and tacrolimus is recommended and adjust the dose when appropriate</li>
</ul>