<p><strong>ACE inhibitors</strong>: Reports suggest that NSAIDs may diminish the antihypertensive effect of ACE inhibitors. This interaction should be given into consideration in patients taking Celecoxib concomitantly with ACE inhibitors.<br />
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<strong>Frusemide</strong>: NSAIDs can reduce the natriuretic effect of Frusemide and thiazides in some patients.<br />
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<strong>Aspirin</strong>: Celecoxib can be used with low dose Aspirin. However, concomitant administration of Aspirin with Celecoxib may result in an increased rate of gastrointestinal ulceration or similar complications, compared to the use of Celecoxib alone.<br />
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<strong>Fluconazole</strong>: Concomitant administration of Fluconazole at 200 mg qid resulted in a two fold increase in Celecoxib plasma concentration. Celecoxib should be introduced at the lowest recommended dose in patients receiving Fluconazole.<br />
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<strong>Lithium</strong>: Patients on Lithium treatment should be closely monitored when Celecoxib is introduced or withdrawn.<br />
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<strong>Warfarin</strong>: Caution should be used when administering Celecoxib with Warfarin since these patients are at increased risk of bleeding complications.<br />
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Co-administration of Celecoxib with aluminium and magnesium-containing&nbsp;antacid should be avoided, because they may reduce the amount of Celecoxib that the body absorbs.</p>