<p><strong>Patients with Severe Renal Impairment</strong>: No dose adjustment is needed for mild or moderate renal impairment (CrCl&gt;30 mL/min). For patients with severe renal impairment (CrCl&ge;15 to &lt;30 mL/min) the recommended dose of Betrixaban is an initial single dose of 80 mg followed by 40 mg once daily.<br />
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<strong>Patients with Hepatic Impairment</strong>: No dose adjustment is required in patients with mild hepatic impairment. Avoid use in patients with moderate to severe hepatic impairment.</p>