<p>No data are available regarding overdosage in humans. Should accidental ocular overdosage occur,&nbsp;flush&nbsp;eye(s) with water or normal&nbsp;saline. If accidentally ingested, efforts to decrease further absorption may be appropriate (gastric&nbsp;lavage). The most common signs and symptoms to be expected with overdosage with administration of a systemic beta-adrenergic blocking agent are symptomatic&nbsp;bradycardia,&nbsp;hypotension, bronchospasm, and acute cardiac failure. Should these symptoms occur, discontinue Levobunolol therapy and initiate appropriate supportive therapy. The following supportive measures should be considered:<br />
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<strong>Symptomatic bradycardia</strong>: Use&nbsp;atropine&nbsp;sulfate intravenously in a dosage of 0.25 mg to 2 mg to induce vagal blockade. If bradycardia persists, intravenous isoproterenol hydrochloride should be administered cautiously. In&nbsp;refractory&nbsp;cases the use of a transvenous cardiac&nbsp;pacemaker&nbsp;should be considered.<br />
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<strong>Hypotension</strong>: Use sympathomimetic&nbsp;pressor&nbsp;drug therapy, such as&nbsp;dopamine, dobutamine or levarterenol. In refractory cases the use of&nbsp;glucagon&nbsp;hydrochloride may be useful.<br />
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<strong>Bronchospasm</strong>: Use isoproterenol hydrochloride. Additional therapy with aminophylline may be considered.<br />
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<strong>Acute cardiac failure</strong>: Conventional therapy with digitalis, diuretics and oxygen should be instituted immediately. In refractory cases the use of intravenous aminophylline is suggested. This may be followed, if necessary, by glucagon hydrochloride which may be useful.<br />
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<strong>Heart block&nbsp;(second or third degree)</strong>: Use isoproterenol hydrochloride or a transvenous cardiac pacemaker.</p>