<p>A number of drugs affect glucose metabolism and may require dose adjustment.<br />
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<strong>The following substances may reduce the Insulin as well as Insulin glargine requirements</strong>: Oral anti-diabetic products, angiotensin converting enzyme (ACE) inhibitors, disopyramide, fibrates, fluoxetine, monoamine oxidase inhibitors, propoxyphene, pentoxifylline, salicylates and sulfonamide antibiotics.<br />
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<strong>The following substances may increase the Insulin as well as Insulin glargine requirements</strong>: Thiazides, glucocorticoids, thyroid hormones, beta-sympathomimetics, growth hormone and danazol. Beta-blockers, clonidine, lithium salts, and alcohol may either potentiate or weaken the blood-glucose-lowering effect of insulin.</p>