<p><strong>Recommended dose</strong>: 40 mg to 120 mg once daily with or without food. Initiate dose at 20 mg once daily for 2 days and then increase to 40 mg once daily. Based on efficacy and tolerability, increase dose in increments of 40 mg at intervals of 2 or more days. The maximum recommended dose is 120 mg once daily. Take capsules whole; do not open, chew or crush.<br />
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<strong>Renal Impairment</strong>: Do not exceed 80 mg once daily for moderate impairment. Do not exceed 40 mg once daily for severe renal impairment.<br />
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<strong>Discontinuation</strong>: Reduce dose gradually whenever possible.</p>