<p>Administer as a 90-minute intravenous infusion followed by LV and 5-FU. A reduction in the starting dose by one dose level may be considered for patients with any of the following conditions: prior pelvic/abdominal radiotherapy, performance status of 2, or increased bilirubin levels.<br />
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<strong>Refractory colorectal malignancies</strong>: 125 mg/m2&nbsp;once wkly for 4 wk, followed by a 2 wk rest period.<br />
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<strong>Metastatic colorectal cancer</strong>: As 1st &nbsp;line treatment: 125 mg/m2&nbsp;on days 1,8,15 and 22 of a 6-wk cycle.</p>