<p><strong>Recommended Doses And Schedules</strong>: The recommended dose of Trastuzumab Emtansine is 3.6 mg/kg given as an intravenous infusion every 3 weeks (21-day cycle) until disease progression or unacceptable toxicity.&nbsp;Do not administer Trastuzumab Emtansine at doses greater than 3.6 mg/kg.&nbsp;Do not substitute Trastuzumab Emtansine for or with trastuzumab. Closely monitor the infusion site for possible subcutaneous infiltration during drug administration<br />
<br />
<strong>First Infusion</strong>: Administer infusion over 90 minutes. Patients should be observed during the infusion and for at least 90 minutes following the initial dose for fever, chills, or other infusionrelated reactions&nbsp;<br />
<br />
<strong>Subsequent Infusions</strong>: Administer over 30 minutes if prior infusions were well tolerated. Patients should be observed during the infusion and for at least 30 minutes after infusion.</p>