<p><strong>Treatment of infection</strong>: 0.3 to 1.2 million units repeated every five to seven days.<br />
<br />
<strong>Prophylaxis of rheumatic fever</strong>: 1.2 million units every three weeks.<br />
<br />
<strong>Specific dosage schedule</strong>:&nbsp;Treatment of group-A &beta;-haemolytic streptococcal infections: A single intramuscular dose of 600,000 units.<br />
<br />
<strong>Prevention of rheumatic fever</strong>: Monthly injection of a single dose of 1.2 million units is the most effective regimen for preventing further attacks of rheumatic fever.<br />
<br />
<strong>Treatment of acute otitis media</strong>: A single injection of 6 million units.</p>

<ul>
	<li><strong>Early syphilis</strong>- 2.4 million units as a single dose.</li>
	<li><strong>Late syphilis:</strong>&nbsp;2.4 million units weekly for three successive weeks.</li>
	<li><strong>Neurosyphilis:</strong>&nbsp;Benzylpenicillin, intravenously, 2 to 4 million units every 4 hours for 10 days, followed by benzathine penicillin intramuscularly, 2.4 million units weekly for three successive weeks.</li>
	<li><strong>Congenital syphilis</strong>: Asymptomatic infants with normal cerebrospinal fluid, intramuscularly 50,000 units per kg in a single dose.</li>
</ul>

<p>Primary and secondary syphilis have been treated with single injections of 2.4 million units of long acting benzathine penicillin (Benzapen) weekly for 2 to 4 weeks with satisfactory results.</p>