<p><strong>Dosage Adjustments for Hepatic Impairment</strong>: For patients with moderate to severe hepatic impairment, the maximum recommended dosage is 2 mg once daily for patients with MDD, and 3 mg once daily for patients with schizophrenia<br />
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<strong>Dosage Adjustments for Renal Impairment</strong>: For patients with moderate, severe or end-stage renal impairment (creatinine clearance ClCr&lt;60 mL/minute), the maximum recommended dosage is 2 mg once daily for patients with MDD and 3 mg once daily for patients with schizophrenia<br />
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<strong>Pediatric Use</strong>: Safety and effectiveness in pediatric patients have not been established. Antidepressants increased the risk of suicidal thoughts and behaviors in pediatric patients<br />
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<strong>Geriatric Use</strong>: In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, and cardiac function, concomitant diseases, and other drug therapy.</p>