<p>Reversal of central depression from opioid use during surgery:</p>

<ul>
	<li><strong>Adult:&nbsp;</strong>100-200 mcg at intervals of 2-3 minute, titrate dose according to response while maintaining analgesia.</li>
	<li><strong>Child:</strong>&nbsp;5-10 mcg IV at 2-3 min intervals.</li>
</ul>

<p>Opioid overdosage:</p>

<ul>
	<li><strong>Adult:</strong>&nbsp;0.4-2 mg repeated if necessary at 2-3 min intervals. If there is no response after a total of 10 mg has been given, consider the possibility of overdosage with other drugs. Reduce dose for opioid-dependent patients: 0.1-0.2 mg. IM/SC routes may be used (at IV doses) if IV admin is not feasible.</li>
	<li><strong>Child:&nbsp;</strong>Initially 10 mcg/kg IV followed by 100 mcg/kg IV if necessary. Alternatively, 0.4-0.8 mg IM or SC, repeated as necessary, if IV admin is not feasible.</li>
</ul>

<p>Opioid-induced depression in neonates due to obstetric analgesia:</p>

<ul>
	<li><strong>Child:&nbsp;</strong>10 mcg/kg IV, IM or SC repeated at 2-3 min intervals if necessary or 60 mcg/kg as a single IM dose.</li>
</ul>