<p>This tablet is contraindicated in patients with:</p>

<ul>
	<li>Renal disease or renal dysfunction, e.g., as suggested by serum creatinine levels &ge;1.5 mg/dL [males], &ge;1.4 mg/dL [females] or abnormal creatinine clearance which may also result from conditions such as cardiovascular collapse (shock), acute myocardial infarction, and septicemia</li>
	<li>Acute or chronic metabolic acidosis, including diabetic ketoacidosis, with or without coma.</li>
	<li>History of a serious hypersensitivity reaction to this tablet or sitagliptin, such as anaphylaxis or angioedema.</li>
</ul>

<p>This tablet should be temporarily discontinued in patients undergoing radiologic studies involving intravascular administration of iodinated contrast materials, because use of such products may result in acute alteration of renal function.</p>