<p>Contact with the mouth, eyes and mucous membranes and with abraded&nbsp;or eczematous skin should be avoided. Care should be taken not to let the medication&nbsp;accumulate in skin fold areas and in the angles of the nose. Application to sensitive areas of skin,&nbsp;such as the neck, should be made with caution. Although Tretinoin has not been shown to initiate&nbsp;or promote carcinogenesis in humans, Tretinoin applied topically to albino hairless mice had&nbsp;resulted in a dose-related acceleration in ultraviolet-B radiation induced cutaneous tumours. The&nbsp;same author also observed the opposite effect in another study of low, non-irritating&nbsp;concentrations of Tretinoin. The significance of these findings as related to man is unknown;&nbsp;however, caution should be observed in patients with a personal or family history of cutaneous&nbsp;epithelioma. Exposure to sunlight of areas treated with Isotretinoin should be avoided or&nbsp;minimised. When exposure to strong sunlight cannot be avoided a sunscreen product and&nbsp;protective clothing should be used. Patients with sunburn should not use Isotretinoin due to the&nbsp;possibility of increased sensitivity to sunlight. The use of sunlamps should be avoided during&nbsp;treatment.</p>