<p><strong>Pediatric Use</strong>: Alendronic acid is not indicated for use in pediatric patients.<br />
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<strong>Renal Impairment</strong>: Alendronic acid is not recommended for patients with creatinine clearance less than 35 mL/min. No dosage adjustment is necessary in patients with creatinine clearance values between 35-60 mL/min.<br />
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<strong>Hepatic Impairment</strong>: As there is evidence that alendronate is not metabolized or excreted in the bile, no studies were conducted in patients with hepatic impairment. No dosage adjustment is necessary.</p>