<p>Hypoglycaemia:&nbsp;Omission of a meal or unplanned strenuous physical exercise may lead to hypoglycaemia. Hypoglycaemia may occur if the insulin dose is too high in relation to the insulin requirement. Concomitant illness, especially infections and fever, usually increases the patient&#39;s insulin requirement. Concomitant diseases in the kidney, liver or diseases affecting the adrenal, pituitary or thyroid gland may require changes in the insulin dose.<br />
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Hyperglycaemia:&nbsp;Administration of rapid-acting insulin is recommended in situations with severe hyperglycaemia. Inadequate dosing and/or discontinuation of treatment in patients requiring insulin may lead to hyperglycaemia and potentially to diabetic ketoacidosis. Furthermore, concomitant illness, especially infections, may lead to hyperglycaemia and thereby cause an increased insulin requirement.<br />
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Eye disorder:&nbsp;Intensification of insulin therapy with abrupt improvement in glycaemic control may be associated with temporary worsening of diabetic retinopathy, while long-term improved glycaemic control decreases the risk of progression of diabetic retinopathy.<br />
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Avoidance of accidental mix-ups:&nbsp;Patients must be instructed to always check the insulin label before each injection to avoid accidental mix-ups between this and other insulin products.<br />
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Older patients (&gt; 65 years old): Insulin Degludec &amp; Insulin Aspart Premixed&nbsp;can be used in older patients. Glucose-monitoring is to be intensified and the insulin dose adjusted on an individual basis.<br />
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Paediatric population:&nbsp;This Insulin has been administered to children and adolescents up to 18 years of age for the investigation of pharmacokinetic properties. Safety and efficacy have not been investigated in children and adolescents.</p>