<p><strong>Pediatric Uses:</strong>&nbsp;Safety and effectiveness of combination of Pioglitazone and Glimepiride in pediatric patients have not been established.<br />
<br />
Geriatric use:</p>

<ul>
	<li><strong>Pioglitazone:</strong>&nbsp;Results of the population pharmacokinetic analysis showed that age does not significantly affect the pharmacokinetics of Pioglitazone. Therefore, no dosage adjustments are required for the elderly.</li>
	<li><strong>Glimepiride:</strong>&nbsp;The drug is known to be substantially excreted by the kidney, and the risk of toxic reactions to this drug may be greater in patients with impaired renal function. Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function.</li>
</ul>