<p><strong>Use in Patients with Renal Impairment</strong>: The usual regimens of therapy with 50/12.5 may be followed as long as the patient&#39;s creatinine clearance is &gt;30 ml/min. In patients with more severe renal impairment, loop diuretics are preferred to thiazides. In that case, hydrochlorothiazide is not recommended.<br />
<br />
<strong>Use in Patients with Hepatic Impairment</strong>: The combination of Losartan and Hydrochlorothiazide is not recommended for titration in patients with hepatic impairment because the appropriate 25 mg starting dose of Losartan cannot be given.<br />
<br />
<strong>Use in pediatric patients</strong>: The safety and effectiveness in pediatric patients have not been established.</p>