<p>Levobunolol ophthalmic&nbsp;solution is contraindicated in those individuals with bronchial asthma, or with a history of bronchial asthma, or severe&nbsp;chronic obstructive pulmonary disease;&nbsp;sinus&nbsp;bradycardia; second and third degree&nbsp;atrioventricular&nbsp;block; overt cardiac failure; cardiogenic&nbsp;shock; or hypersensitivity to any component of these products.</p>