<p>Caregivers should be instructed in the recommended administration (twice per day for doses above 5 mg) and dose escalation (minimum interval of one week between dose increases). If the patients suffer from kidney dysfunction, the kidney function should be monitored at regular basis.<br />
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<strong>Seizures:</strong>&nbsp;Memantine has not been systematically evaluated in patients with a seizure disorder. One clinical trial shows that seizures occurred in 0.2% of patients treated with Memantine and 0.5% of patients treated with placebo.<br />
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<strong>Carcinogenesis, Mutagenesis and Impairment of Fertility:</strong>&nbsp;Study shows that no risk of carcinogenesis, mutagenesis and impairment of fertility are caused after Memantine use.<br />
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<strong>Operating Vehicles or Machinery</strong>: Taking Memantine may alter the reaction time significantly; therefore safe driving and safe operation of machinery may no longer be possible.</p>