<p><strong>Pediatric Use</strong>: Safety and effectiveness in pediatric patients have not been established.<br />
<br />
<strong>Geriatric Use</strong>: Clinical studies of temozolomide did not include sufficient numbers of subjects aged 65 and over to determine whether they responded differently from younger subjects. Other reported clinical experience has not identified differences in responses between the elderly and younger patients. In general, dose selection for an elderly patient should be cautious, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.<br />
<br />
<strong>Renal Impairment</strong>: Caution should be exercised when temozolomide is administered to patients with severe renal impairment<br />
<br />
<strong>Hepatic Impairment</strong>: Caution should be exercised when temozolomide is administered to patients with severe hepatic impairment</p>