<p>Patients taking concomitant ACE inhibitor therapy may be at increased risk for angioedema. Interstitial lung disease/noninfectious pneumonitis; monitor for clinical symptoms or radiological changes; fatal cases have occurred; manage by dose reduction or discontinuation until symptoms resolve, and consider use of corticosteroids; pulmonary hypertension (including pulmonary arterial hypertension) as a secondary event reported<br />
<br />
Elicits immunosuppressive effects and may increase risk for infections; some infections have been severe or fatal; monitor for signs and symptoms and treat promptly. Pneumocystis jiroveci pneumonia, some with a fatal outcome, reported; this may be associated with concomitant use of corticosteroids or other immunosuppressive agents<br />
<br />
Mouth ulcers, stomatitis, and oral mucositis are common; management includes mouthwashes (without alcohol or peroxide) and topical treatments May delay wound healing and increase wound-related complications (eg, dehiscence, wound infection, incisional hernia, lymphocele, and seroma)</p>

<ul>
	<li>Cases of renal failure (including acute renal failure), some fatal, have been observed</li>
	<li>May cause angioedema and fluid accumulation</li>
	<li>Decreases Hgb, lymphocytes, ANC, platelets; increases cholesterol, TG, glucose, creatinine</li>
	<li>Elevations of serum creatinine, urinary protein, blood glucose, and lipids may occur;</li>
	<li>decreases in hemoglobin, neutrophils, and platelets may also occur; monitor renal</li>
	<li>function, blood glucose, lipids, and hematologic parameters prior to treatment and periodically thereafter</li>
	<li>May impair male fertility</li>
	<li>Child-Pugh Class C hepatic impairment</li>
	<li>Avoid use of live vaccines during treatment and close contact with live vaccine recipients</li>
	<li>Can cause fetal harm when administered to a pregnant woman; advise female patients of reproductive potential to use highly effective contraception while receiving everolimus and for up to 8 weeks after ending treatment.</li>
</ul>