<p>Hypoglycemia may occur with concomitant use with insulin &amp; insulin secretagogues eg sulfonylureas. Decrease in Cmax &amp; AUC with rifampin. Increase in Cmax &amp; AUC with mefenamic acid. Increased thiazide &amp; loop diuretic effects; may increase risk of dehydration &amp; hypotension. Pioglitazone.</p>