<p>Perampanel can be taken without regard to food. The dosage of Perampanel is as follows-</p>

<ul>
	<li>Starting dose: 2 mg once daily at bedtime. May increase dose based on clinical response and tolerability by increments of 2 mg once daily no more frequently than at weekly intervals.</li>
	<li>Recommended maintenance dose in monotherapy or adjunctive therapy for partial-onset seizures: 8 mg to 12 mg once daily at bedtime.</li>
	<li>Recommended maintenance dose in adjunctive therapy for primary generalized tonic-clonic seizures: 8 mg once daily at bedtime.</li>
</ul>

<p><strong>Mild and Moderate Hepatic Impairment</strong>: Maximum recommended daily dose is 6 mg (mild) and 4 mg (moderate) once daily at bedtime.<br />
<br />
<strong>Severe Hepatic Impairment</strong>: Not recommended.<br />
<br />
<strong>Severe Renal Impairment</strong>: Not recommended.<br />
<br />
<strong>Elderly</strong>: Increase dose no more frequently than every 2 weeks.</p>