<p>Cerebrovascular Adverse Reactions in Elderly Patients with Dementia-</p>

<ul>
	<li>Related Psychosis: Increased incidence of cerebrovascular adverse reactions (e.g. stroke, transient ischemic attack)</li>
	<li>Neuroleptic Malignant Syndrome: Manage with immediate discontinuation and close monitoring</li>
	<li>Tardive Dyskinesia: Discontinue if clinically appropriate</li>
	<li>Metabolic Changes: Monitor for hyperglycemia/diabetes mellitus, dyslipidemia and weight gain</li>
	<li>Pathological Gambling and Other Compulsive Behaviors: Consider dose reduction or discontinuation</li>
	<li>Leukopenia, Neutropenia, and Agranulocytosis: Perform complete blood counts (CBC) in patients with pre-existing low white blood cell count (WBC) or history of leukopenia or neutropenia. Consider discontinuing Brexpiprazole if a clinically significant decline in WBC occurs in absence of other causative factors</li>
	<li>Orthostatic Hypotension and Syncope: Monitor heart rate and blood pressure and warn patients with known cardiovascular or cerebrovascular disease, and risk of dehydration or syncope</li>
	<li>Seizures: Use cautiously in patients with a history of seizures or with conditions that lower the seizure threshold</li>
</ul>