<ul>
	<li>Hypersensitivity to the active substance or to any of the excipients.</li>
	<li>Any type of acute metabolic acidosis (such as lactic acidosis, diabetic ketoacidosis).</li>
	<li>Severe renal failure (GFR &lt;30 mL/min).</li>
	<li>Acute conditions with the potential to alter renal function such as: dehydration, severe infection, shock.</li>
	<li>Acute or chronic disease, which may cause tissue hypoxia such as: cardiac or respiratory failure, recent myocardial infarction, shock, Hepatic insufciency, acute alcohol intoxication, alcoholism.</li>
</ul>