<p><strong>Antidepressant Medications</strong>: Melatonin reduces the antidepressant effects of desipramine and fluoxetine. In addition, fluoxetine leads to measurable depletion of melatonin in people.<br />
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<strong>Antipsychotic Medications</strong>: People with schizophrenia and tardive dyskinesia taking antipsychotic medications with melatonin has significantly reduced mouth movements compared to those who did not take the supplements.<br />
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<strong>Benzodiazepines</strong>: The combination of melatonin and triazolam improves sleep quality. In addition, there have been a few reports suggesting that melatonin supplements may help individuals stop using long-term benzodiazepine therapy.<br />
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<strong>Blood Pressure Medications</strong>: Melatonin may reduce the effectiveness of blood pressure medications like methoxamine and clonidine. In addition, calcium channel blockers (such as nifedipine, verapamil, diltiazem, amlodipine, nimodipine, felodipine, nisoldipine, and bepridil) may decrease melatonin levels. The use of beta-blockers (propranolol, acebutolol, atenolol, labetalol, metoprolol, pindolol, nadolol, sotalol, and timolol) may reduce melatonin production in the body.<br />
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<strong>Blood-Thinning Medications, Anticoagulants</strong>: Melatonin may increase the risk of bleeding from anticoagulant medications such as warfarin.<br />
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<strong>Interleukin-2</strong>: In one study of 80 cancer patients, the use of melatonin in conjunction with interleukin-2 led to more tumor regression and better survival rates than treatment with interleukin-2 alone.<br />
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<strong>Nonsteroidal Anti-inflammatory Drugs (NSAIDs)</strong>: NSAIDs such as ibuprofen may reduce the levels of melatonin in the blood.<br />
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<strong>Steroids and Immunosuppressant Medications</strong>: People should not take melatonin with corticosteroids or other medications used to suppress the immune system because the supplement may cause them to be ineffective.<br />
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<strong>Tamoxifen</strong>: Preliminary research suggests that the combination of tamoxifen (a chemotherapy drug) and melatonin may benefit certain patients with breast and other cancers.<br />
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<strong>Other Substances</strong>: Caffeine, tobacco, and alcohol can all diminish levels of melatonin in the body while cocaine and amphetamines may increase melatonin production.</p>