<p><strong>Combinations not recommended</strong>: Calcium antagonists of the verapamil and diltiazem type, centrally-acting antihypertensive drugs.<br />
<br />
<strong>Combinations to be used with caution</strong>: Strong or moderate CYP3A4 inhibitors, CYP3A4 inducers, simvastatin, Tacrolimus, Cyclosporine, class I antiarrhythmic drugs, class III antiarrhythmic drugs, parasympathomimetic drugs, topical beta-blockers (e.g. eye drops), insulin and oral antidiabetic drugs, anesthetic agents, digitalis glycosides, non-steroidal anti-inflammatory drugs (NSAIDs), sympathomimetic agents, antihypertensive agents and other drugs with blood pressure lowering potential.<br />
<br />
<strong>Combinations to be considered</strong>: Mefloquine, Rifampicin, Ergotamine derivatives, MAO inhibitors (except MAO-B inhibitor).</p>