<p><strong>Adult:</strong>&nbsp;The usual recommended initial and maintenance dose is Irbesartan 150 mg once daily, with&nbsp;or without food. Irbesartan at a dose of 150 mg once daily generally provides a better 24 hour&nbsp;blood pressure control than 75 mg. However, initiation of therapy with Irbesartan 75 mg could&nbsp;be considered, particularly in haemodialysed patients and in the elderly over 75 years.&nbsp;In patients insufficiently controlled with Irbesartan 150 mg once daily, the dose of Irbesartan&nbsp;can be increased to Irbesartan 300 mg, or other anti-hypertensive agents can be added. In particular, the addition of a diuretic such as hydrochlorothiazide has been shown to have an&nbsp;additive effect with Irbesartan.&nbsp;In hypertensive type 2 diabetic patients, therapy should be initiated at Irbesartan 150 mg&nbsp;once daily and titrated up to Irbesartan 300 mg once daily as the preferred maintenance dose&nbsp;for treatment of renal disease.&nbsp;The demonstration of renal benefit of Irbesartan in hypertensive type 2 diabetic patients is based&nbsp;on studies where Irbesartan was used in addition to other antihypertensive agents, as needed, to&nbsp;reach target blood pressure.&nbsp;<br />
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<strong>Elderly:</strong>&nbsp;although consideration should be given to initiating therapy with Irbesartan 75 mg in patients over 75 years of age, dosage adjustment is not usually necessary for the elderly<br />
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<strong>Paediatric:</strong>&nbsp;Irbesartan is not recommended for use in children and adolescents due to&nbsp;insufficient data on safety and efficacy.</p>