<p><strong>Recommended Dosage in Adult and Pediatric Patients with Body Surface Area of at Least 1 m2</strong>: The recommended dosage of Larotrectinib is 100 mg orally twice daily, with or without food, until disease progression or until unacceptable toxicity.<br />
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<strong>Recommended Dosage in Pediatric Patients with Body Surface Area Less Than 1 m2</strong>: The recommended dosage of Larotrectinib is 100 mg/m2&nbsp;orally twice daily, with or without food, until disease progression or until unacceptable toxicity. Whole capsules should be swallowed with water and the capsules should not be chewed or crushed. A missed dose should not be made up within 6 hours of the next scheduled dose. If vomiting occurs after taking a dose of Larotrectinib, the next dose should be taken at the scheduled time. Or, as directed by the registered physicians.</p>