<p><strong>Pregnancy</strong>&nbsp;Category B. Teratology studies have been conducted in mice (doses up to 200 mg/kg/day), rats (doses up to 400 mg/kg/day) and rabbits (doses up to 200 mg/kg/day). Doses of 400 mg/kg in rats, 200 mg/kg/day in mice and 100 mg/kg in rabbits produced&nbsp;maternal&nbsp;toxicity, as well as fetal toxicity, but there was no evidence of a teratogenic potential of ticlopidine. There are, however, no adequate and well-controlled studies in&nbsp;pregnant&nbsp;women. Because animal&nbsp;reproduction&nbsp;studies are not always predictive of a human response, this drug should be used during pregnancy only if clearly needed.<br />
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<strong>Nursing Mothers</strong>:&nbsp;Studies in rats have shown ticlopidine is excreted in the milk. It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing infants from ticlopidine, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.</p>