<p>4 mg/kg as an intravenous infusion over 1 hour every 2 weeks.&nbsp;Do not administer as an intravenous (IV) push or bolus.</p>

<p><strong>Administration</strong></p>

<p><strong>Preparation for Administration:&nbsp;</strong>Inspect vials visually prior to use. Aflibercept is a clear, colorless to pale yellow solution. Do not use vial if the solution is discolored or cloudy or if the solution contains particles. Do not re-enter the vial after the initial puncture. Discard any unused portion left in the vial. Withdraw the prescribed dose of Aflibercept and dilute in 0.9% sodium chloride solution, 5% dextrose solution for injection, to achieve a final concentration of 0.6&ndash;8 mg/mL.<br />
<br />
Use polyvinyl chloride (PVC) infusion bags containing bis (2-ethylhexyl) phthalate (DEHP) or polyolefin infusion bags. Store diluted Aflibercept at 2&deg;&ndash;8&deg;C for up to 24 hours, or at controlled room temperature 20&deg;&ndash;25&deg;C for up to 8 hours. Discard any unused portion left in the infusion bag.<br />
<br />
<strong>Administration:&nbsp;</strong>Administer the diluted Aflibercept solution as an intravenous infusion over 1 hour through a 0.2 micron polyethersulfone filter. Do not use filters made of polyvinylidene fluoride (PVDF) or nylon. Do not administer as an intravenous (IV) push or bolus. Do not combine Aflibercept with other drugs in the same infusion bag or intravenous line.</p>