<p><strong>Pediatric Use</strong>: Safety of doses greater than 7 mg/kg of articaine in pediatric patients has not been established. Dosages in pediatric patients should be reduced, commensurate with age, body weight, and physical condition.<br />
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<strong>Renal or Hepatic Insufficiency</strong>: No studies have been performed with articaine and epinephrine in renal and hepatic impaired patient.</p>