<p>The usual dose of Levofloxacin Tablets is 250 mg or 500 mg or 750 mg administered orally every 24 hours. Levofloxacin tablets can be administered without regard to food. Levofloxacin oral solution should be taken 1 hour before, or&nbsp; 2 hours after eating.<br />
<br />
Levofloxacin injection should only be administered by intravenous infusion. It is not for intramuscular, intrathecal, intraperitoneal, or subcutaneous administration. The usual dose of Levofloxacin injection is 250 mg or 500 mg administered by slow infusion over 60 minutes every 24 hours or 750 mg administered by slow infusion over 90 minutes every 24 hours. Since the Levofloxacin injections are for single-use only, any unused portion should be discarded. Additives or other medications should not be added to Levofloxacin Injection or infused simultaneously through the same intravenous line.<br />
<br />
Adults:</p>

<ul>
	<li><strong>Acute sinusitis</strong>: 500 mg once daily for 10-14 days, or 750 mg once daily for 5 days</li>
	<li><strong>Exacerbation of chronic bronchitis</strong>: 500 mg once daily for 7 days, or 750 mg once daily for 3 days (Uncomplicated), 750 mg once daily for 5 days (Complicated)</li>
	<li><strong>Community-acquired pneumonia</strong>: 500 mg once daily for 7-14 days, or 750 mg once daily for 5 days</li>
	<li><strong>Uncomplicated urinary-tract infections</strong>: 250 mg once daily for 3 days</li>
	<li><strong>Complicated urinary-tract infections and acute pyelonephritis</strong>: 250 mg once daily for 7-10 days</li>
	<li><strong>Uncomplicated skin and soft-tissue infections</strong>: 500 mg once daily for 7-10 days.</li>
	<li><strong>Complicated skin and soft-tissue infections</strong>: 750 mg once daily for 7-14 days.</li>
	<li><strong>Enteric fever</strong>: 500 mg once daily for 7-14 days.</li>
	<li><strong>Diarrhea, cholera, shigellosis &amp; enteritis</strong>: Mild to moderate case: 500 mg (single dose). Moderate to sever case: 500 mg once daily for 3 days</li>
</ul>

<p>Children:</p>

<ul>
	<li><strong>Children 6 months to &lt;5 years</strong>: 10 mg/kg every 12 hours.</li>
	<li><strong>Children &gt;5 years</strong>: 10 mg/kg every 24 hours</li>
</ul>

<p>In each case, sequential therapy (intravenous to oral) may be instituted at the discretion of the physician.</p>

<p>&nbsp;</p>

<p><strong>Administration</strong></p>

<p>Instructions for the Use of Levofloxacin Infusion-</p>

<ul>
	<li>Check the container for minute leaks by squeezing the inner bag firmly. If leaks are found, or if the seal is not intact, discard the solution.</li>
	<li>Do not use if the solution is cloudy or a precipitate is present.</li>
	<li>Do not use flexible containers in series connections.</li>
	<li>Close flow control clamp of administration set.</li>
	<li>Remove cover from port at bottom of container.</li>
	<li>Insert piercing pin of administration set into port with a twisting motion until the pin is firmly seated.</li>
	<li>Suspend container from hanger.</li>
	<li>Squeeze and release drip chamber to establish proper fluid level in chamber during infusion of Levoxin Injection.</li>
	<li>Open flow control clamp to expel air from set. Close clamp.</li>
	<li>Regulate rate of administration with flow control clamp.</li>
</ul>