<p>No significant drug interactions has not been observed but close monitoring of patients is required when it is used with:</p>

<ul>
	<li><strong>Lithium and Digoxin</strong>: may increase plasma concentration of lithium and digoxin.</li>
	<li><strong>Diuretics</strong>: may interact the activity of diuretics.</li>
	<li><strong>Anticoagulants</strong>: may enhance the activity of anticoagulant.</li>
	<li><strong>Methotrexate</strong>: may increase the plasma level of methotrexate.</li>
</ul>