<p>It is recommended that doses of Lamivudine should be adjusted in accordance with renal function. Dosage adjustment of Lamivudine in accordance with creatinine clearance is as follows:</p>

<ul>
	<li><strong>CrCl 50 ml/min</strong>: 100 mg once daily</li>
	<li><strong>CrCl 30-49 ml/min</strong>: 100 mg first dose, then 50 mg once daily</li>
	<li><strong>CrCl 15-29 ml/min</strong>: 100 mg first dose, then 25 mg once daily</li>
	<li><strong>CrCl 5-14 ml/min</strong>: 35 mg first dose, then 15 mg once daily</li>
	<li><strong>CrCl &lt;5 ml/min</strong>: 35 mg first dose, then 10 mg once daily</li>
</ul>

<p><strong>Use in children</strong>: Safety and efficacy of lamivudine for the treatment of chronic hepatitis B in children have not been established.</p>