<p><strong>PCI/PTCA</strong>: IV Bolus dose of 0.75 mg/kg followed by an infusion of 1.75 mg/kg/h for duration of PCI procedure. Five minutes after bolus dose, obtain ACT and administer additional bolus of 0.3 mg/kg if indicated.<br />
<br />
<strong>HIT/HITTS</strong>: IV Bolus dose of 0.75 mg/kg, followed by a continuous infusion at a rate of 1.75 mg/kg/h for the duration of the procedure.<br />
<br />
<strong>Continuation of Therapy</strong>: IV Infusion may be continued for up to 4 h post-procedure as indicated. After 4 h, an additional IV infusion of 0.2 mg/kg/h for up to 20 h may be given if needed.<br />
<br />
<strong>Concomitant Therapy</strong>: Bivalirudin is intended for concurrent use with aspirin (300 to 325 mg/day).</p>

<p>&nbsp;</p>

<p><strong>Administration</strong></p>

<ul>
	<li>For IV administration only. Not for intradermal, subcutaneous, IM, or intra-arterial administration.</li>
	<li>Reconstitute powder for injection with 5 mL sterile water for injection. Gently swirl until powder is dissolved.</li>
	<li>For initial bolus infusion, further dilute each reconstituted via in 50 mL of 5% dextrose in water or sodium chloride 0.9% for injection to yield a final concentration of 5 mg/mL.</li>
	<li>For low rate infusion, further dilute each reconstituted vial in 500 mL of 5% dextrose in water or sodium chloride 0.9% for injection to yield a final concentration of 0.5 mg/mL.</li>
	<li>Do not mix with the following drugs in the same IV line: alteplase, amiodarone, amphotericin B, chlorpromazine, diazepam, dobutamine, prochlorperazine, reteplase, streptokinase, vancomycin.</li>
	<li>Reconstituted bivalirudin should be a clear to slightly opalescent, colorless to slightly yellow solution. Do not administer if reconstituted or diluted solution is discolored, cloudy, or contains particulate matter.</li>
	<li>Maintain meticulous catheter technique, with frequent aspiration and flushing, paying special attention to minimizing conditions of stasis within the catheter or vessels.</li>
	<li>Discard any unused reconstituted or diluted solution.</li>
</ul>