<p><strong>Risk of Bleeding</strong>: Can cause bleeding. Promptly evaluate any signs or symptoms of blood loss.<br />
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<strong>Spinal/Epidural Anesthesia or Puncture</strong>: When neuraxial anesthesia (spinal/epidural anesthesia) or spinal/epidural puncture is employed, patients treated with antithrombotic agents for prevention of thromboembolic complications are at risk of developing an epidural or spinal hematoma which can result in long-term or permanent paralysis. Do not remove an epidural catheter earlier than 72 hours after the last administration of Betrixaban. Do not administer the next Betrixaban dose earlier than 5 hours after the removal of the catheter. If traumatic puncture occurs, delay the administration of Betrixaban for 72 hours.<br />
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<strong>Severe Renal Impairment</strong>: Increase risk of bleeding events.<br />
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<strong>Concomitant P-gp Inhibitors</strong>: Increase risk of bleeding events</p>