<p>Hypersensitivity; abnormally low neutrophil counts (&lt;0.75 x 109/L) or Hb levels (&lt;7.5 g/dL or 4.65 mmol/L); newborn infants with hyperbilirubinaemia requiring treatment other than phototherapy, or with increased transaminase levels &gt;5 times the ULN. Lactation. Concomitant use with interferon alfa (with or witho ribavirin) in HIV and hepatitis B or C virus co-infected patients.</p>